Metabolic pathway to genes

Genes assigned in the pathway

Query pathway ID 00064
Pathway name The cinnamate-monolignol pathway/sinapoyl ester biosynthesis
Organism Arabidopsis_thaliana
Database KaPPA-View 4

Click Gene ID to show a list of co-expressed genes.

Gene ID Repr. ID Gene name Functional description O.I. H.G. Other DB
At1g09480837471cinnamyl-alcohol dehydrogenase family / CAD familysimilar to Eucalyptus gunnii alcohol dehydrogenase of unknown physiological function (GI:1143445), Vigna unguiculata (gi:1854445), NOT a cinnamyl-alcohol dehydrogenaseO.I.H.G.
At1g09490837474cinnamyl-alcohol dehydrogenase family / CAD familysimilar to Eucalyptus gunnii alcohol dehydrogenase of unknown physiological function (GI:1143445), Vigna unguiculata (gi:1854445), NOT a cinnamyl-alcohol dehydrogenase; Location of EST gb:H37170, gb:H77227 and gb:AA605565O.I.H.G.
At1g09500837475cinnamyl-alcohol dehydrogenase family / CAD familysimilar to Eucalyptus gunnii alcohol dehydrogenase of unknown physiological function (GI:1143445), Vigna unguiculata (gi:1854445), NOT a cinnamyl-alcohol dehydrogenaseO.I.H.G.
At1g09510837476cinnamyl-alcohol dehydrogenase family / CAD familysimilar to Eucalyptus gunnii alcohol dehydrogenase of unknown physiological function (GI:1143445), Vigna unguiculata (gi:1854445), NOT a cinnamyl-alcohol dehydrogenaseO.I.H.G.
At1g15950838165CCR1 (CINNAMOYL COA REDUCTASE 1)Encodes a cinnamoyl CoA reductase. Involved in lignin biosynthesis.O.I.H.G.
At1g15960838166NRAMP6member of Nramp2 familyO.I.H.G.
At1g15970838167methyladenine glycosylase family proteinF:DNA-3-methyladenine glycosylase I activity, catalytic activity;P:DNA repair, base-excision repair;C:cellular_component unknown;BOPMAFO.I.H.G.
At1g204808386364-coumarate--CoA ligase family protein / 4-coumaroyl-CoA synthase family proteinF:4-coumarate-CoA ligase activity;P:phenylpropanoid metabolic process, metabolic process;C:cellular_component unknown;BOFMPAVO.I.H.G.
At1g20490838637AMP-dependent synthetase and ligase family proteinF:4-coumarate-CoA ligase activity;P:phenylpropanoid metabolic process, metabolic process;C:unknown;BOMFPAVO.I.H.G.
At1g205008386384-coumarate-CoA ligaseF:4-coumarate-CoA ligase activity;P:phenylpropanoid metabolic process, metabolic process;C:unknown;BOMFPAVO.I.H.G.
At1g20510838639OPCL1 (OPC-8:0 COA LIGASE1)F:4-coumarate-CoA ligase activity;P:phenylpropanoid metabolic process, jasmonic acid biosynthetic process, response to wounding;C:peroxisome;BOFMPAVO.I.H.G.
At1g21100838706O-methyltransferase, putativeF:methyltransferase activity, O-methyltransferase activity, protein dimerization activity;P:unknown;C:cytosol;PBFOMO.I.H.G.
At1g21110838707O-methyltransferase, putativeF:methyltransferase activity, O-methyltransferase activity, protein dimerization activity;P:unknown;C:cytosol;PBFOMO.I.H.G.
At1g21120838708O-methyltransferase, putativeF:methyltransferase activity, O-methyltransferase activity, protein dimerization activity;P:unknown;C:cytosol;PBFMOO.I.H.G.
At1g21130838709O-methyltransferase, putativeF:methyltransferase activity, protein dimerization activity, O-methyltransferase activity;P:unknown;C:cytosol;PBFOMO.I.H.G.
At1g24735839082O-methyltransferaseF:O-methyltransferase activity;P:unknown;C:cytosol;BOPMFAO.I.H.G.
At1g33030840198O-methyltransferase family 2 proteinF:O-methyltransferase activity;P:lignin biosynthetic process;C:cytosol;PBFOMO.I.H.G.
At1g51410841566cinnamyl-alcohol dehydrogenase, putative (CAD)similar to Eucalyptus gunnii alcohol dehydrogenase of unknown physiological function (GI:1143445), apple tree, PIR:T16995; NOT a cinnamyl-alcohol dehydrogenaseO.I.H.G.
At1g516808415934CL1 (4-COUMARATE:COA LIGASE 1)encodes an isoform of 4-coumarate:CoA ligase (4CL), which is involved in the last step of the general phenylpropanoid pathway. In addition to 4-coumarate, it also converts ferulate. The catalytic efficiency was in the following (descending) order: p-coumaric acid, ferulic acid, caffeic acid and 5-OH-ferulic acid. At4CL1 was unable to use sinapic acid as substrate.O.I.H.G.
At1g51990841628O-methyltransferase family 2 proteinF:O-methyltransferase activity;P:lignin biosynthetic process;C:cytosol;PBFOMO.I.H.G.
At1g62940842596ACOS5 (ACYL-COA SYNTHETASE 5)encodes an acyl-CoA synthetase, has in vitro activity towards medium- to long-chain fatty acids and their hydroxylated derivatives. Expressed in the tapetum. Involved in pollen wall exine formation. Null mutants were devoid of pollen grains at anther maturity and were completely male sterile.O.I.H.G.
At1g63140842618O-methyltransferase, putativeF:methyltransferase activity, protein dimerization activity, O-methyltransferase activity;P:unknown;C:cytosol;PBOMFO.I.H.G.
At1g650608428144CL3encodes an isoform of 4-coumarate:CoA ligase (4CL), which is involved in the last step of the general phenylpropanoid pathway. mRNA levels are not induced in response to wounding or to fungal infection by P. parasitica. mRNA is expressed in flowers, to a lesser degree in mature leaves and siliques and marginally in seedling roots and bolting stems of mature plants. The catalytic efficiency was in the following (descending) order: p-coumaric acid, caffeic acid, ferulic acid, cinnamic acid and 5-OH-ferulic acid. At4CL3 was unable to use sinapic acid as substrate.O.I.H.G.
At1g66800842998cinnamyl-alcohol dehydrogenase family / CAD familysimilar to Eucalyptus gunnii alcohol dehydrogenase of unknown physiological function (GI:1143445), apple tree, PIR:T16995; NOT a cinnamyl-alcohol dehydrogenaseO.I.H.G.
At1g67980843126CCoAMTEncodes S-adenosyl-L-methionine: transcaffeoyl Coenzyme A 3-O-methyltransferase.O.I.H.G.
At1g67990843127TSM1Encodes a tapetum-specific O-methyltransferase. In vitro enzyme assay indicated activity with caffeoyl-CoA, caffeoyl glucose, chlorogenic acid and polyamine conjugates. RNAi mutants had impaired silique development and seed setting.O.I.H.G.
At1g68540843183oxidoreductase family proteinF:coenzyme binding, oxidoreductase activity, binding, catalytic activity;P:cellular metabolic process, metabolic process;C:cellular_component unknown;BOPFMAVO.I.H.G.
At1g72680843600cinnamyl-alcohol dehydrogenase, putativeF:in 6 functions;P:lignin biosynthetic process;C:unknown;BOPFMAVO.I.H.G.
At1g764708439803-beta-hydroxy-delta5-steroid dehydrogenase/ binding / catalytic/ cinnamoyl-CoA reductaseF:3-beta-hydroxy-delta5-steroid dehydrogenase activity, binding, cinnamoyl-CoA reductase activity, catalytic activity;P:lignin biosynthetic process, steroid biosynthetic process, metabolic process;C:endomembrane system;OBPFMAVO.I.H.G.
At1g76790844013O-methyltransferase family 2 proteinF:methyltransferase activity, O-methyltransferase activity, protein dimerization activity;P:unknown;C:cytosol;PBFOMO.I.H.G.
At1g77520844088O-methyltransferase family 2 proteinF:O-methyltransferase activity;P:lignin biosynthetic process;C:cytosol;PBFOMO.I.H.G.
At1g77530844089O-methyltransferase family 2 proteinF:O-methyltransferase activity;P:lignin biosynthetic process;C:cytosol;PBFOMAO.I.H.G.
At1g80820844421CCR2 (CINNAMOYL COA REDUCTASE)Encodes an cinnamoyl CoA reductase isoform. Involved in lignin biosynthesis.O.I.H.G.
At1g80830844422NRAMP1 (NATURAL RESISTANCE-ASSOCIATED MACROPHAGE PROTEIN 1)Thought to be involved in iron homeostasis. Induced in leaves in response to iron deficiency. Transgenic plants accumulate toxic levels of iron. Gene complements yeast iron uptake mutants.O.I.H.G.
At2g02400814771cinnamoyl-CoA reductase familyF:coenzyme binding, binding, cinnamoyl-CoA reductase activity, catalytic activity;P:lignin biosynthetic process, cellular metabolic process, metabolic process;C:plasma membrane;BOPFMAVO.I.H.G.
At2g21730816710CAD2 (CINNAMYL ALCOHOL DEHYDROGENASE HOMOLOG 2)F:oxidoreductase activity, binding, zinc ion binding, catalytic activity;P:oxidation reduction, metabolic process;C:unknown;BOPFMAVO.I.H.G.
At2g21890816725CAD3 (CINNAMYL ALCOHOL DEHYDROGENASE HOMOLOG 3)F:oxidoreductase activity, binding, zinc ion binding, catalytic activity;P:oxidation reduction, metabolic process;C:unknown;BOPFMAVO.I.H.G.
At2g22990816830SNG1 (SINAPOYLGLUCOSE 1)sinapoylglucose:malate sinapoyltransferase. Catalyzes the formation of sinapoylmalate from sinapoylglucose. Mutants accumulate excess sinapoylglucose.O.I.H.G.
At2g23910816923cinnamoyl-CoA reductase-relatedF:coenzyme binding, binding, cinnamoyl-CoA reductase activity, catalytic activity;P:lignin biosynthetic process, cellular metabolic process, metabolic process;C:cellular_component unknown;POBFMO.I.H.G.
At2g30490817599C4H (CINNAMATE-4-HYDROXYLASE)Encodes a cinnamate-4-hydroxylase.O.I.H.G.
At2g33590817925cinnamoyl-CoA reductase familyF:coenzyme binding, binding, cinnamoyl-CoA reductase activity, catalytic activity;P:response to cadmium ion, lignin biosynthetic process;C:cellular_component unknown;BOPFMAVO.I.H.G.
At2g33600817926cinnamoyl-CoA reductase familyF:coenzyme binding, binding, cinnamoyl-CoA reductase activity, catalytic activity;P:lignin biosynthetic process, cellular metabolic process, metabolic process;C:unknown;BOPFMAVO.I.H.G.
At2g37040818280pal1 (Phe ammonia lyase 1)encodes a protein similar to phenylalanine ammonia-lyaseO.I.H.G.
At2g40890818686CYP98A3 (cytochrome P450, family 98, subfamily A, polypeptide 3)encodes coumarate 3-hydroxylase (C3H), a P450-dependent monooxygenase. Involved in lignin biosynthesis and flavonoid biosynthesis. Also affects the biosynthesis of coumarins such as scopoletin and scopolin as a branching-out-pathway from the phenylpropanoid acid level.O.I.H.G.
At3g10340820196PAL4 (Phenylalanine ammonia-lyase 4)F:ammonia-lyase activity, ammonia ligase activity, catalytic activity;P:L-phenylalanine catabolic process, biosynthetic process;C:cytoplasm;BPOFMAO.I.H.G.
At3g19450821479ATCAD4Encodes a catalytically active cinnamyl alcohol dehydrogenase which uses p-coumaryl aldehyde as a preferred substrate. It can also use caffeyl, coniferyl and d-hydroxyconiferyl aldehydes as substrates.O.I.H.G.
At3g212308216774CL5 (4-coumarate:CoA ligase 5)The gene encodes a 4-coumarate coenzyme A ligase being able to use sinapate as substrate. The catalytic efficiency was in the following (descending) order: p-coumaric acid, caffeic acid, 5-OH-ferulic acid, ferulic acid and sinapic acid. At4CL5 was unable to use cinnamic acid as substrate. Knockout of At4CL5 (4cl5) revealed no effect on syringyl lignin content indicating that the activity observed does probably not occur in vivo.O.I.H.G.
At3g212408216784CL2 (4-COUMARATE:COA LIGASE 2)encodes an isoform of 4-coumarate:CoA ligase (4CL), which is involved in the last step of the general phenylpropanoid pathway. The catalytic efficiency was in the following (descending) order: p-coumaric acid, caffeic acid, ferulic acid, 5-OH-ferulic acid and cinnamic acid. At4CL2 was unable to use sinapic acid as substrate.O.I.H.G.
At3g24503822042ALDH2C4Arabidopsis thaliana aldehyde dehydrogenase AtALDH1a mRNA. a sinapaldehyde dehydrogenase catalyzes both the oxidation of coniferylaldehyde and sinapaldehyde forming ferulic acid and sinapic acid, respectivelyO.I.H.G.
At3g48990824060AMP-dependent synthetase and ligase family proteinF:catalytic activity, AMP binding;P:response to cadmium ion;C:apoplast, chloroplast;BOFMPAVO.I.H.G.
At3g53140824480O-diphenol-O-methyl transferase, putativeF:methyltransferase activity, protein dimerization activity, O-methyltransferase activity;P:biological_process unknown;C:unknown;PBFOMO.I.H.G.
At3g53260824493PAL2Encodes phenylalanine lyase.O.I.H.G.
At3g61990825372O-methyltransferase family 3 proteinF:O-methyltransferase activity;P:unknown;C:cytosol;BOPMFAO.I.H.G.
At3g62000825373O-methyltransferase family 3 proteinF:O-methyltransferase activity;P:unknown;C:cytosol;BOPMFAO.I.H.G.
At4g051608258644-coumarate--CoA ligase, putative / 4-coumaroyl-CoA synthase, putativeEncodes a peroxisomal protein involved in the activation of fatty acids through esterification with CoA. At4g05160 preferentially activates fatty acids with medium chain length (C6:0 and C7:0) as well as even-numbered long-chain fatty acids (C14:0, C16:0 and C18:0). At4g05160 was also able to catalyze the conversion of OPC-6:0 to its CoA ester and is therefore thought to be involved in the peroxisomal β-oxidation steps of jasmonic acid biosynthesis.O.I.H.G.
At4g190108276394-coumarate--CoA ligase family protein / 4-coumaroyl-CoA synthase family proteinF:4-coumarate-CoA ligase activity;P:metabolic process;C:unknown;BOFMPAVO.I.H.G.
At4g26220828728caffeoyl-CoA 3-O-methyltransferase, putativeF:O-methyltransferase activity;P:unknown;C:cytosol;BOPMFAO.I.H.G.
At4g30470829170cinnamoyl-CoA reductase-relatedF:coenzyme binding, binding, cinnamoyl-CoA reductase activity, catalytic activity;P:lignin biosynthetic process, cellular metabolic process, metabolic process;C:cellular_component unknown;POBFMAO.I.H.G.
At4g34050829551caffeoyl-CoA 3-O-methyltransferase, putativeF:caffeoyl-CoA O-methyltransferase activity;P:coumarin biosynthetic process, response to cadmium ion;C:cytosol;BOPMFAO.I.H.G.
At4g34230829572ATCAD5 (CINNAMYL ALCOHOL DEHYDROGENASE 5)Encodes a catalytically active cinnamyl alcohol dehydrogenase which uses p-coumaryl aldehyde as a preferred substrate. It can also use sinapyl, caffeyl, coniferyl and d-hydroxyconiferyl aldehydes as substrates.O.I.H.G.
At4g35160829668O-methyltransferase family 2 proteinF:methyltransferase activity, O-methyltransferase activity, protein dimerization activity;P:unknown;C:cytosol;PBFMOO.I.H.G.
At4g36220829779FAH1 (FERULIC ACID 5-HYDROXYLASE 1)encodes ferulate 5-hydroxylase (F5H). Involved in lignin biosynthesis.O.I.H.G.
At4g37970829953CAD6 (CINNAMYL ALCOHOL DEHYDROGENASE 6)F:oxidoreductase activity, binding, catalytic activity, zinc ion binding;P:oxidation reduction, metabolic process;C:cellular_component unknown;BOPFMAVO.I.H.G.
At4g37980829954ELI3-1 (ELICITOR-ACTIVATED GENE 3-1)F:oxidoreductase activity, binding, zinc ion binding, catalytic activity;P:response to bacterium, plant-type hypersensitive response;C:unknown;BOPFMAVO.I.H.G.
At4g37990829955ELI3-2 (ELICITOR-ACTIVATED GENE 3-2)Encodes an aromatic alcohol:NADP+ oxidoreductase whose mRNA levels are increased in response to treatment with a variety of phytopathogenic bacteria. Though similar to mannitol dehydrogenases, this enzyme does not have mannitol dehydrogenase activity.O.I.H.G.
At4g39060830061-F:molecular_function unknown;P:biological_process unknown;C:cellular_component unknown;POBO.I.H.G.
At4g39330830088CAD9 (CINNAMYL ALCOHOL DEHYDROGENASE 9)F:oxidoreductase activity, binding, zinc ion binding, catalytic activity;P:oxidation reduction, metabolic process;C:apoplast;BOPFMAVO.I.H.G.
At5g04230830302PAL3 (PHENYL ALANINE AMMONIA-LYASE 3)Member of Phenylalanine ammonialyase (PAL) gene family.Differs significantly from PAL1 and PAL2 and other sequenced plant PAL genesO.I.H.G.
At5g04330830312cytochrome P450, putative / ferulate-5-hydroxylase, putativeF:electron carrier activity, monooxygenase activity, iron ion binding, oxygen binding, heme binding;P:unknown;C:endomembrane system;MPFBOAVO.I.H.G.
At5g14700831322cinnamoyl-CoA reductase-relatedF:binding, 3-beta-hydroxy-delta5-steroid dehydrogenase activity, cinnamoyl-CoA reductase activity, catalytic activity;P:lignin biosynthetic process, steroid biosynthetic process, metabolic process;C:cellular_component unknown;POBFMVAO.I.H.G.
At5g19440832064cinnamyl-alcohol dehydrogenase, putative (CAD)similar to Eucalyptus gunnii alcohol dehydrogenase of unknown physiological function (GI:1143445), apple tree, PIR:T16995; NOT a cinnamyl-alcohol dehydrogenaseO.I.H.G.
At5g37170833690O-methyltransferase family 2 proteinF:O-methyltransferase activity;P:lignin biosynthetic process;C:cytosol;PBFOMO.I.H.G.
At5g381208337924-coumarate--CoA ligase family protein / 4-coumaroyl-CoA synthase family proteinF:4-coumarate-CoA ligase activity;P:metabolic process;C:unknown;BOFMPAVO.I.H.G.
At5g48930834951HCT (HYDROXYCINNAMOYL-COA SHIKIMATE/QUINATE HYDROXYCINNAMOYL TRANSFERASE)At5g48930 has been shown to encode for the hydroxycinnamoyl-Coenzyme A shikimate/quinate hydroxycinnamoyltransferase (HCT) both synthesizing and catabolizing the hydroxycinnamoylesters (coumaroyl/caffeoyl shikimate and quinate) involved in the phenylpropanoid pathway. Influence on the accumulation of flavonoids which in turn inhibit auxin transport and reduce plant growth.O.I.H.G.
At5g53810835462O-methyltransferase, putativeF:methyltransferase activity, protein dimerization activity, O-methyltransferase activity;P:unknown;C:cytosol;PBFOMO.I.H.G.
At5g54160835504ATOMT1 (O-METHYLTRANSFERASE 1)A caffeic acid/5-hydroxyferulic acid O-methyltransferase. Interacts with 14-4-3 proteins in yeast 2 hybrid assay. AtOMT1 (At5g54160) encodes a flavonol 3-O-methyltransferase that is highly active towards quercetin and myricetin. The substrate specificity identifies the enzyme as flavonol 3-methyltransferase which replaces the former annotation of the gene to encode a caffeic acid/5-hydroxyferulic acid O-methyltransferaseO.I.H.G.
At5g58490835962cinnamoyl-CoA reductase familyF:3-beta-hydroxy-delta5-steroid dehydrogenase activity, binding, cinnamoyl-CoA reductase activity, catalytic activity;P:lignin biosynthetic process, steroid biosynthetic process, metabolic process;C:cellular_component unknown;BOPFMAVO.I.H.G.
At5g633808364574-coumarate--CoA ligase family protein / 4-coumaroyl-CoA synthase family proteinEncodes a peroxisomal protein involved in the activation of fatty acids through esterification with CoA. At5g63380 preferentially activates fatty acids with increased chain length (C9:0 to C8:0) and thus shares characteristics with long-chain fatty acyl-CoA synthases. Also able to catalyze the conversion of OPDA to its CoA ester and is therefore thought to be involved in the peroxisomal β-oxidation steps of jasmonic acid biosynthesis.O.I.H.G.

Comparison with co-expressed genes



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