Metabolic pathway to genes

Genes assigned in the pathway

Query pathway ID 00061
Pathway name Flavonoids biosynthesis
Organism Arabidopsis_thaliana
Database KaPPA-View 4

Click Gene ID to show a list of co-expressed genes.

Gene ID Repr. ID Gene name Functional description O.I. H.G. Other DB
At1g02050839280chalcone and stilbene synthase family proteinF:transferase activity, transferring acyl groups other than amino-acyl groups, catalytic activity, acyltransferase activity;P:phenylpropanoid biosynthetic process, pollen exine formation;C:unknown;PBOFO.I.H.G.
At1g13520837912unknown proteinF:molecular_function unknown;P:unknown;C:cellular_component unknown;PO.I.H.G.
At1g204808386364-coumarate--CoA ligase family protein / 4-coumaroyl-CoA synthase family proteinF:4-coumarate-CoA ligase activity;P:phenylpropanoid metabolic process, metabolic process;C:cellular_component unknown;BOFMPAVO.I.H.G.
At1g20490838637AMP-dependent synthetase and ligase family proteinF:4-coumarate-CoA ligase activity;P:phenylpropanoid metabolic process, metabolic process;C:unknown;BOMFPAVO.I.H.G.
At1g205008386384-coumarate-CoA ligaseF:4-coumarate-CoA ligase activity;P:phenylpropanoid metabolic process, metabolic process;C:unknown;BOMFPAVO.I.H.G.
At1g20510838639OPCL1 (OPC-8:0 COA LIGASE1)F:4-coumarate-CoA ligase activity;P:phenylpropanoid metabolic process, jasmonic acid biosynthetic process, response to wounding;C:peroxisome;BOFMPAVO.I.H.G.
At1g25460839132oxidoreductase family proteinF:coenzyme binding, oxidoreductase activity, binding, catalytic activity;P:cellular metabolic process, metabolic process, flavonoid biosynthetic process;C:cellular_component unknown;BOPFMAVO.I.H.G.
At1g49390841362oxidoreductase, 2OG-Fe(II) oxygenase family proteinF:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors, oxidoreductase activity;P:flavonoid biosynthetic process;C:cellular_component unknown;POBFMO.I.H.G.
At1g516808415934CL1 (4-COUMARATE:COA LIGASE 1)encodes an isoform of 4-coumarate:CoA ligase (4CL), which is involved in the last step of the general phenylpropanoid pathway. In addition to 4-coumarate, it also converts ferulate. The catalytic efficiency was in the following (descending) order: p-coumaric acid, ferulic acid, caffeic acid and 5-OH-ferulic acid. At4CL1 was unable to use sinapic acid as substrate.O.I.H.G.
At1g61720842469BAN (BANYULS)Negative regulator of flavonoid biosynthesis, mutants accumulate flavonoid pigments in their seed coat, putative oxidoreductase. It is thought that a ternary complex composed of TT2, TT8 and TTG1 is necessary for correct expression of BAN in seed endothelium.O.I.H.G.
At1g62940842596ACOS5 (ACYL-COA SYNTHETASE 5)encodes an acyl-CoA synthetase, has in vitro activity towards medium- to long-chain fatty acids and their hydroxylated derivatives. Expressed in the tapetum. Involved in pollen wall exine formation. Null mutants were devoid of pollen grains at anther maturity and were completely male sterile.O.I.H.G.
At1g650608428144CL3encodes an isoform of 4-coumarate:CoA ligase (4CL), which is involved in the last step of the general phenylpropanoid pathway. mRNA levels are not induced in response to wounding or to fungal infection by P. parasitica. mRNA is expressed in flowers, to a lesser degree in mature leaves and siliques and marginally in seedling roots and bolting stems of mature plants. The catalytic efficiency was in the following (descending) order: p-coumaric acid, caffeic acid, ferulic acid, cinnamic acid and 5-OH-ferulic acid. At4CL3 was unable to use sinapic acid as substrate.O.I.H.G.
At1g78550844191oxidoreductase, 2OG-Fe(II) oxygenase family proteinF:oxidoreductase activity, iron ion binding;P:unknown;C:unknown;POBFMO.I.H.G.
At2g30490817599C4H (CINNAMATE-4-HYDROXYLASE)Encodes a cinnamate-4-hydroxylase.O.I.H.G.
At2g38240818403oxidoreductase, 2OG-Fe(II) oxygenase family proteinF:oxidoreductase activity;P:response to salt stress;C:unknown;POBFMO.I.H.G.
At2g44800819089oxidoreductase, 2OG-Fe(II) oxygenase family proteinF:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors, oxidoreductase activity;P:biological_process unknown;C:cellular_component unknown;POBFMO.I.H.G.
At3g10340820196PAL4 (Phenylalanine ammonia-lyase 4)F:ammonia-lyase activity, ammonia ligase activity, catalytic activity;P:L-phenylalanine catabolic process, biosynthetic process;C:cytoplasm;BPOFMAO.I.H.G.
At3g19000821433oxidoreductase, 2OG-Fe(II) oxygenase family proteinF:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors, oxidoreductase activity, iron ion binding;P:biological_process unknown;C:cellular_component unknown;POBFMO.I.H.G.
At3g19010821434oxidoreductase, 2OG-Fe(II) oxygenase family proteinF:flavonol synthase activity, oxidoreductase activity, iron ion binding;P:flavonoid biosynthetic process;C:cellular_component unknown;POBFMO.I.H.G.
At3g212308216774CL5 (4-coumarate:CoA ligase 5)The gene encodes a 4-coumarate coenzyme A ligase being able to use sinapate as substrate. The catalytic efficiency was in the following (descending) order: p-coumaric acid, caffeic acid, 5-OH-ferulic acid, ferulic acid and sinapic acid. At4CL5 was unable to use cinnamic acid as substrate. Knockout of At4CL5 (4cl5) revealed no effect on syringyl lignin content indicating that the activity observed does probably not occur in vivo.O.I.H.G.
At3g212408216784CL2 (4-COUMARATE:COA LIGASE 2)encodes an isoform of 4-coumarate:CoA ligase (4CL), which is involved in the last step of the general phenylpropanoid pathway. The catalytic efficiency was in the following (descending) order: p-coumaric acid, caffeic acid, ferulic acid, 5-OH-ferulic acid and cinnamic acid. At4CL2 was unable to use sinapic acid as substrate.O.I.H.G.
At3g48990824060AMP-dependent synthetase and ligase family proteinF:catalytic activity, AMP binding;P:response to cadmium ion;C:apoplast, chloroplast;BOFMPAVO.I.H.G.
At3g502108241832-oxoacid-dependent oxidase, putativeF:oxidoreductase activity, iron ion binding;P:aging, cellular response to starvation;C:unknown;POBFMO.I.H.G.
At3g51240824287F3H (FLAVANONE 3-HYDROXYLASE)Encodes flavanone 3-hydroxylase that is coordinately expressed with chalcone synthase and chalcone isomerases. Regulates flavonoid biosynthesis.O.I.H.G.
At3g53260824493PAL2Encodes phenylalanine lyase.O.I.H.G.
At3g55120824678TT5 (TRANSPARENT TESTA 5)Catalyzes the conversion of chalcones into flavanones. Required for the accumulation of purple anthocyanins in leaves and stems.O.I.H.G.
At4g00040828224chalcone and stilbene synthase family proteinF:transferase activity, transferring acyl groups other than amino-acyl groups, catalytic activity, acyltransferase activity;P:phenylpropanoid biosynthetic process, biosynthetic process, metabolic process;C:unknown;PBOFO.I.H.G.
At4g051608258644-coumarate--CoA ligase, putative / 4-coumaroyl-CoA synthase, putativeEncodes a peroxisomal protein involved in the activation of fatty acids through esterification with CoA. At4g05160 preferentially activates fatty acids with medium chain length (C6:0 and C7:0) as well as even-numbered long-chain fatty acids (C14:0, C16:0 and C18:0). At4g05160 was also able to catalyze the conversion of OPC-6:0 to its CoA ester and is therefore thought to be involved in the peroxisomal β-oxidation steps of jasmonic acid biosynthesis.O.I.H.G.
At4g10490826641oxidoreductase, 2OG-Fe(II) oxygenase family proteinF:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors, oxidoreductase activity;P:secondary metabolic process;C:cellular_component unknown;POBFMO.I.H.G.
At4g16330827327oxidoreductase/ oxidoreductase, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donorsF:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors, oxidoreductase activity;P:flavonoid biosynthetic process;C:peroxisome;POBFMO.I.H.G.
At4g190108276394-coumarate--CoA ligase family protein / 4-coumaroyl-CoA synthase family proteinF:4-coumarate-CoA ligase activity;P:metabolic process;C:unknown;BOFMPAVO.I.H.G.
At4g22870828386leucoanthocyanidin dioxygenase, putative / anthocyanidin synthase, putativeF:oxidoreductase activity;P:unknown;C:cellular_component unknown;POBFMO.I.H.G.
At4g22880828387LDOX (LEUCOANTHOCYANIDIN DIOXYGENASE)encodes leucoanthocyanidin dioxygenase, which is involved in proanthocyanin biosynthesis. Mutant analysis suggests that this gene is also involved in vacuole formation.O.I.H.G.
At4g27250828833dihydroflavonol 4-reductase family / dihydrokaempferol 4-reductase familyF:cinnamyl-alcohol dehydrogenase activity;P:cellular metabolic process, metabolic process;C:cellular_component unknown;BOPFMAVO.I.H.G.
At4g33360829473terpene cyclase/mutase-relatedF:coenzyme binding, binding, catalytic activity;P:cellular metabolic process, terpenoid metabolic process, metabolic process;C:endoplasmic reticulum, plasma membrane, vacuole;BOPFMAVO.I.H.G.
At4g34850829637chalcone and stilbene synthase family proteinF:transferase activity, transferring acyl groups other than amino-acyl groups, catalytic activity, acyltransferase activity;P:phenylpropanoid biosynthetic process, pollen exine formation;C:cellular_component unknown;PBOFO.I.H.G.
At4g35420829695dihydroflavonol 4-reductase family / dihydrokaempferol 4-reductase familyF:coenzyme binding, binding, catalytic activity;P:cellular metabolic process, metabolic process;C:endomembrane system;BOPFMAVO.I.H.G.
At5g04230830302PAL3 (PHENYL ALANINE AMMONIA-LYASE 3)Member of Phenylalanine ammonialyase (PAL) gene family.Differs significantly from PAL1 and PAL2 and other sequenced plant PAL genesO.I.H.G.
At5g05270830409chalcone-flavanone isomerase family proteinF:chalcone isomerase activity;P:flavonoid biosynthetic process;C:cellular_component unknown;PO.I.H.G.
At5g07990830693TT7 (TRANSPARENT TESTA 7)Required for flavonoid 3' hydroxylase activity.O.I.H.G.
At5g08640830765FLS (FLAVONOL SYNTHASE)Encodes a flavonol synthase that catalyzes formation of flavonols from dihydroflavonols.O.I.H.G.
At5g13930831241TT4 (TRANSPARENT TESTA 4)Encodes chalcone synthase (CHS), a key enzyme involved in the biosynthesis of flavonoids. Required for the accumulation of purple anthocyanins in leaves and stems. Also involved in the regulation of auxin transport and the modulation of root gravitropism.O.I.H.G.
At5g20400832162oxidoreductase, 2OG-Fe(II) oxygenase family proteinencodes a protein whose sequence is similar to flavanone 3 hydroxylase from Malus.O.I.H.G.
At5g24530832524DMR6 (DOWNY MILDEW RESISTANT 6)Encodes a putative 2OG-Fe(II) oxygenase that is defense-associated but required for susceptibility to downy mildew.O.I.H.G.
At5g381208337924-coumarate--CoA ligase family protein / 4-coumaroyl-CoA synthase family proteinF:4-coumarate-CoA ligase activity;P:metabolic process;C:unknown;BOFMPAVO.I.H.G.
At5g42800834291DFR (DIHYDROFLAVONOL 4-REDUCTASE)dihydroflavonol reductase. Catalyzes the conversion of dihydroquercetin to leucocyanidin in the biosynthesis of anthocyanins.O.I.H.G.
At5g633808364574-coumarate--CoA ligase family protein / 4-coumaroyl-CoA synthase family proteinEncodes a peroxisomal protein involved in the activation of fatty acids through esterification with CoA. At5g63380 preferentially activates fatty acids with increased chain length (C9:0 to C8:0) and thus shares characteristics with long-chain fatty acyl-CoA synthases. Also able to catalyze the conversion of OPDA to its CoA ester and is therefore thought to be involved in the peroxisomal β-oxidation steps of jasmonic acid biosynthesis.O.I.H.G.
At5g63580836477FLS2 (FLAVONOL SYNTHASE 2)encodes a protein whose sequence is similar to flavonol synthaseO.I.H.G.
At5g63590836478FLS3 (FLAVONOL SYNTHASE 3)F:flavonol synthase activity;P:response to light stimulus, response to sucrose stimulus, flavonoid biosynthetic process;C:cellular_component unknown;POBFMO.I.H.G.
At5g66220836754chalcone isomeraseF:chalcone isomerase activity;P:flavonoid biosynthetic process;C:unknown;PO.I.H.G.

Comparison with co-expressed genes



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