Metabolic pathway to genes

Genes assigned in the pathway

Query pathway ID 01066
Pathway name Biosynthesis of alkaloids derived from terpenoid and polyketide
Organism Arabidopsis_thaliana
Database KEGG PATHWAY

Click Gene ID to show a list of co-expressed genes.

Gene ID Repr. ID Gene name Functional description O.I. H.G. Other DB
At1g01090839429PDH-E1 ALPHA (PYRUVATE DEHYDROGENASE E1 ALPHA)pyruvate dehydrogenase E1 alpha subunitO.I.H.G.
At1g04410839527malate dehydrogenase, cytosolic, putativeF:in 6 functions;P:response to cadmium ion, response to salt stress;C:in 7 components;BOMPFAO.I.H.G.
At1g07420837254SMO2-1 (STEROL 4-ALPHA-METHYL-OXIDASE 2-1)Arabidopsis thaliana sterol 4-alpha-methyl-oxidase mRNAO.I.H.G.
At1g09430837466ACLA-3Encodes subunit A of the heteromeric enzyme ATP citrate lyase (ACL). In animals, ACL is encoded by a single gene; ACL in Arabidopsis is composed of two polypeptides, ACLA (encoded by 3 genes) and ACLB (encoded by 2 genes). The holoenzyme has an A(4)B(4)stoichiometry. Expression of both ACLA and ACLB but not of either of the subunits alone results in ACL activity.O.I.H.G.
At1g097808375072,3-biphosphoglycerate-independent phosphoglycerate mutase, putative / phosphoglyceromutase, putativeF:manganese ion binding, phosphoglycerate mutase activity, 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity, catalytic activity, metal ion binding;P:response to cadmium ion, response to cold;C:cytosol, mitochondrial envelope, chloroplast, plasma membrane;BOPFAMO.I.H.G.
At1g10670837610ACLA-1One of the three genes encoding subunit A of the trimeric protein ATP Citrate Lyase. Antisense ACLA-1 plants cause a reduction in cytosolic acetyl-CoA metabolism and have upregulation of stress-related genes and down-regulation of primary metabolism and growth genes, suggesting the mutation restricts normal growth and developmental processes and puts the plant into a state of stress.O.I.H.G.
At1g11680837712CYP51G1 (CYTOCHROME P450 51G1)putative obtusifoliol 14-alpha demethylase involved in sterol biosynthesis.O.I.H.G.
At1g12900837848GAPA-2 (GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE A SUBUNIT 2)F:NAD or NADH binding, glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity, binding, glyceraldehyde-3-phosphate dehydrogenase activity, catalytic activity;P:glycolysis, glucose metabolic process, metabolic process;C:apoplast, chloroplast stroma, chloroplast, membrane, chloroplast envelope;BOPFMAO.I.H.G.
At1g13440837904GAPC2 (GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE C2)F:NAD or NADH binding, glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity, binding, catalytic activity, glyceraldehyde-3-phosphate dehydrogenase activity;P:response to oxidative stress, response to cadmium ion, gluconeogenesis, defense response to bacterium, glycolysis;C:in 8 components;BOPFMAO.I.H.G.
At1g16300838199GAPCP-2F:NAD or NADH binding, glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity, binding, catalytic activity, glyceraldehyde-3-phosphate dehydrogenase activity;P:glycolysis, glucose metabolic process, metabolic process;C:plastid;BOPFMAO.I.H.G.
At1g20050838593HYD1 (HYDRA1)C-8 sterol isomeraseO.I.H.G.
At1g24180839031IAR4Arabidopsis thaliana pyruvate dehydrogenase E1a-like subunit. 81% identical to a previously characterized Arabidopsis mitochondrial PDH E1a-subunit, At1g59900O.I.H.G.
At1g30120839891PDH-E1 BETA (PYRUVATE DEHYDROGENASE E1 BETA)Encodes a putative plastid pyruvate dehydrogenase E1 beta subunit that is distinct from the mitochondrial pyruvate dehydrogenase E1 beta subunit.O.I.H.G.
At1g31910840081GHMP kinase family proteinF:kinase activity, ATP binding;P:phosphorylation;C:unknown;FPOBAO.I.H.G.
At1g32440840138PKp3 (plastidial pyruvate kinase 3)encodes a chloroplast pyruvate kinase beta subunit. The enzyme is less active than the other chloroplast pyruvate kinase beta subunit encoded by AT5G52920. Involved in seed oil biosynthesis. Can partially complement the AT5G52920 mutant.O.I.H.G.
At1g32480840142oxidoreductase/ oxidoreductase, acting on the CH-OH group of donors, NAD or NADP as acceptorF:oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;P:metabolic process;C:unknown;BOMFAPO.I.H.G.
At1g34430840346EMB3003 (embryo defective 3003)F:dihydrolipoyllysine-residue acetyltransferase activity, protein binding, acyltransferase activity;P:embryonic development ending in seed dormancy;C:cytosolic ribosome, plasma membrane, chloroplast, chloroplast envelope;OBMFPAO.I.H.G.
At1g42970840895GAPB (GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE B SUBUNIT)Encodes chloroplast localized glyceraldehyde-3-phosphate dehydrogenase.O.I.H.G.
At1g47840841200HXK3 (HEXOKINASE 3)Encodes a putative hexokinase.O.I.H.G.
At1g48030841221mtLPD1 (mitochondrial lipoamide dehydrogenase 1)Encodes a mitochondrial lipoamide dehydrogenase whose expression is induced by light.O.I.H.G.
At1g49530841377GGPS6 (geranylgeranyl pyrophosphate synthase 6)encodes a mitochondria-targeted geranylgeranyl pyrophosphate synthaseO.I.H.G.
At1g50430841465DWF5 (DWARF 5)Mutants are defective in Brassinosteroid biosynthesis (delta7-sterol-C7 reduction step) and have a dwarf phenotype.O.I.H.G.
At1g53240841757malate dehydrogenase (NAD), mitochondrialF:malate dehydrogenase activity;P:response to cadmium ion, response to salt stress, response to cold, defense response to bacterium, peptidyl-cysteine S-nitrosylation;C:mitochondrion, cell wall, chloroplast;BOMPFAO.I.H.G.
At1g54220841863dihydrolipoamide S-acetyltransferase, putativeF:dihydrolipoyllysine-residue acetyltransferase activity, protein binding, acyltransferase activity;P:pyruvate metabolic process, metabolic process, acetyl-CoA biosynthetic process from pyruvate;C:mitochondrion;OBMFPAO.I.H.G.
At1g54340841875ICDH (ISOCITRATE DEHYDROGENASE)NADP-specific isocitrate dehydrogenase (ICDH)O.I.H.G.
At1g56190842072phosphoglycerate kinase, putativeF:phosphoglycerate kinase activity;P:response to cadmium ion, glycolysis;C:thylakoid, mitochondrion, chloroplast stroma, chloroplast, membrane;OBPMAFO.I.H.G.
At1g58440842213XF1Encodes a putative protein that has been speculated, based on sequence similarities, to have squalene monooxygenase activity.O.I.H.G.
At1g59900842284AT-E1 ALPHAencodes the e1 alpha subunit of the pyruvate dehydrogenase complex (PDC)O.I.H.G.
At1g60810842375ACLA-2One of the three genes encoding subunit A of the trimeric enzyme ATP Citrate lyaseO.I.H.G.
At1g63970842700ISPFEncodes a protein with 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity. The protein's activity was confirmed by heterologous expression of phenotypic complementation of the E. coli ispF mutant. Plants defective in this gene display an albino lethal phenotype.Homolog of E. coli IspFO.I.H.G.
At1g65930842905isocitrate dehydrogenase, putative / NADP+ isocitrate dehydrogenase, putativeF:isocitrate dehydrogenase (NADP+) activity, copper ion binding;P:response to cadmium ion, response to salt stress, metabolic process;C:apoplast, plasma membrane;OBMPFAO.I.H.G.
At1g74030843741enolase, putativeF:phosphopyruvate hydratase activity;P:in 12 processes;C:phosphopyruvate hydratase complex, chloroplast;OBMFAPO.I.H.G.
At1g76490843982HMG1 (HYDROXY METHYLGLUTARYL COA REDUCTASE 1)Encodes a 3-hydroxy-3-methylglutaryl coenzyme A reductase, which is involved in melavonate biosynthesis and performs the first committed step in isoprenoid biosynthesis. Expression is activated in dark in leaf tissue but not controlled by light in the root (confineO.I.H.G.
At1g79530844291GAPCP-1 (GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE OF PLASTID 1)F:NAD or NADH binding, glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity, binding, catalytic activity, glyceraldehyde-3-phosphate dehydrogenase activity;P:glycolysis, glucose metabolic process, metabolic process;C:plastid, membrane;BOPFMAO.I.H.G.
At1g79550844293PGK (PHOSPHOGLYCERATE KINASE)Encodes cytosolic phosphoglycerate kinase (PGK).O.I.H.G.
At1g79750844314ATNADP-ME4 (NADP-malic enzyme 4)The malic enzyme (EC 1.1.1.40) encoded by AtNADP-ME4 is localized to chloroplasts. The gene is expressed throughout the whole plant and during embryogenesis and germination. A possible involvement in the fatty acid biosynthesis has been proposed.O.I.H.G.
At2g01140814643fructose-bisphosphate aldolase, putativeF:fructose-bisphosphate aldolase activity;P:response to oxidative stress, response to cadmium ion, pentose-phosphate shunt;C:mitochondrion, chloroplast, plastoglobule;OMBPFO.I.H.G.
At2g02500814779ISPDEncodes a protein with 4-Diphosphocytidyl-2C-methyl-D-erythritol synthase activity. The enzyme has an absolute requirement for divalent cations (Mg2+ reaches the highest catalytic activity).O.I.H.G.
At2g05710815120aconitate hydratase, cytoplasmic, putative / citrate hydro-lyase/aconitase, putativeProtein is tyrosine-phosphorylated and its phosphorylation state is modulated in response to ABA in Arabidopsis thaliana seeds.O.I.H.G.
At2g17130816218IDH2 (ISOCITRATE DEHYDROGENASE SUBUNIT 2)NAD+ dependent isocitrate dehydrogenase subunit 2 (IDH2)O.I.H.G.
At2g17370816244HMG2 (3-HYDROXY-3-METHYLGLUTARYL-COA REDUCTASE 2)Encodes a 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) that is involved in the synthesis of sterol and triterpenoid compounds.O.I.H.G.
At2g18450816359SDH1-2Nuclear encoded mitochondrial flavoprotein subunit of succinate dehydrogenase complex .O.I.H.G.
At2g18620816377geranylgeranyl pyrophosphate synthase, putative / GGPP synthetase, putative / farnesyltranstransferase, putativeF:unknown;P:isoprenoid biosynthetic process;C:unknown;OBPFAMVO.I.H.G.
At2g18640816379GGPS4 (GERANYLGERANYL PYROPHOSPHATE SYNTHASE 4)Encodes an endoplasmic reticulum-targeted geranylgeranyl pyrophosphate synthaseO.I.H.G.
At2g19860816505HXK2 (HEXOKINASE 2)Encodes a protein with hexokinase activity (AtHXK2) and acts as a sensor for plant sugar responses.O.I.H.G.
At2g19900816509ATNADP-ME1 (NADP-malic enzyme 1)The malic enzyme (EC 1.1.1.40) encoded by AtNADP-ME1 is expressed in response to developmental and cell-specific signals.O.I.H.G.
At2g20420816561succinyl-CoA ligase (GDP-forming) beta-chain, mitochondrial, putative / succinyl-CoA synthetase, beta chain, putative / SCS-beta, putativeF:succinate-CoA ligase (GDP-forming) activity, ATP binding;P:response to cadmium ion, metabolic process;C:mitochondrion;OBMFAPO.I.H.G.
At2g21330816672fructose-bisphosphate aldolase, putativeF:fructose-bisphosphate aldolase activity, catalytic activity;P:response to cadmium ion, pentose-phosphate shunt;C:in 8 components;OMBPFO.I.H.G.
At2g22480816781PFK5 (PHOSPHOFRUCTOKINASE 5)F:6-phosphofructokinase activity;P:glycolysis;C:6-phosphofructokinase complex, chloroplast;BOMFPAVO.I.H.G.
At2g22780816808PMDH1 (PEROXISOMAL NAD-MALATE DEHYDROGENASE 1)encodes an peroxisomal NAD-malate dehydrogenase that is involved in fatty acid beta-oxidation through providing NAD to the process of converting fatty acyl CoA to acetyl CoA.O.I.H.G.
At2g23800816912GGPS2 (GERANYLGERANYL PYROPHOSPHATE SYNTHASE 2)encodes an endoplasmic reticulum-targeted geranylgeranyl pyrophosphate synthaseO.I.H.G.
At2g26930817234ATCDPMEK (4-(CYTIDINE 5'-PHOSPHO)-2-C-METHYL-D-ERITHRITOL KINASE)Encodes a 4-(cytidine 5'-phospho)-2-C-methyl-D-erithritol kinase.O.I.H.G.
At2g34590818024transketolase family proteinF:pyruvate dehydrogenase (acetyl-transferring) activity, transketolase activity;P:pollen tube development;C:chloroplast, chloroplast envelope;BOMPFAO.I.H.G.
At2g36460818220fructose-bisphosphate aldolase, putativeF:fructose-bisphosphate aldolase activity, catalytic activity;P:response to cadmium ion, response to salt stress, pentose-phosphate shunt;C:mitochondrion, plasma membrane, membrane;OMBPFO.I.H.G.
At2g36530818226LOS2Involved in light-dependent cold tolerance and encodes an enolase. Protein is tyrosine-phosphorylated and its phosphorylation state is modulated in response to ABA in Arabidopsis thaliana seeds.O.I.H.G.
At2g38700818452MVD1 (MEVALONATE DIPHOSPHATE DECARBOXYLASE 1)Encodes mevalonate diphosphate decarboxylase, the enzyme that catalyzes the synthesis of isopentenyl diphosphate, used in sterol and isoprenoid biosynthesis. The protein appears to form a homodimeric complex. Incidentally, it was shown that the Arabidopsis MVD protein could also interact with its yeast homolog to form a heterodimer.O.I.H.G.
At2g42790818879CSY3 (citrate synthase 3)Encodes a peroxisomal citrate synthase that is expressed throughout seedling and shoot development.O.I.H.G.
At2g44350819042ATCSencodes a mitochrondrion targeted citrate synthase, the first enzyme of the tricarboxylic acid cycle, catalyzing the condensation of acetyl-CoA and oxaloacetate, finally yielding citrate and CoA.O.I.H.G.
At2g47510819364FUM1 (FUMARASE 1)fumarase (FUM1)O.I.H.G.
At3g02580820679STE1 (STEROL 1)Brassinosteroid biosynthetic enzyme, catalyzes delta7 sterol C-5 desaturation step. Mutant has dwarf phenotype.O.I.H.G.
At3g02780820960IPP2 (ISOPENTENYL PYROPHOSPHATE:DIMETHYLALLYL PYROPHOSPHATE ISOMERASE 2)Encodes a protein with isopentenyl diphosphate:dimethylallyl diphosphate isomerase activity. There is genetic evidence that it functions in the mevalonate, but not the MEP biosynthetic pathway.O.I.H.G.
At3g04050819560pyruvate kinase, putativeF:pyruvate kinase activity, magnesium ion binding, potassium ion binding, catalytic activity;P:glycolysis;C:cellular_component unknown;BOMPFAO.I.H.G.
At3g04120819567GAPC1 (GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE C SUBUNIT 1)encodes cytosolic GADPH (C subunit) involved in the glycolytic pathway but also interacts with H2O2 potentially placing it in a signalling cascade induced by ROS.O.I.H.G.
At3g06650819845ACLB-1One of the two genes encoding subunit B of the trimeric enzyme ATP Citrate lyaseO.I.H.G.
At3g085908200062,3-biphosphoglycerate-independent phosphoglycerate mutase, putative / phosphoglyceromutase, putativeF:manganese ion binding, phosphoglycerate mutase activity, 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity, catalytic activity, metal ion binding;P:response to cadmium ion;C:cytosol, apoplast;BOPFAMO.I.H.G.
At3g09810820139isocitrate dehydrogenase, putative / NAD+ isocitrate dehydrogenase, putativeF:isocitrate dehydrogenase (NAD+) activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;P:tricarboxylic acid cycle, metabolic process;C:mitochondrion;BOMFAPO.I.H.G.
At3g12780820461PGK1 (PHOSPHOGLYCERATE KINASE 1)nuclear phosphoglycerate kinase (PGK1)O.I.H.G.
At3g13930820606dihydrolipoamide S-acetyltransferase, putativeF:dihydrolipoyllysine-residue acetyltransferase activity, protein binding, acyltransferase activity;P:pyruvate metabolic process, metabolic process;C:mitochondrion, chloroplast, chloroplast envelope;OBMFPAO.I.H.G.
At3g14510820674geranylgeranyl pyrophosphate synthase, putative / GGPP synthetase, putative / farnesyltranstransferase, putativeF:unknown;P:isoprenoid biosynthetic process;C:unknown;OBFPMAVO.I.H.G.
At3g14530820678geranylgeranyl pyrophosphate synthase, putative / GGPP synthetase, putative / farnesyltranstransferase, putativeF:farnesyltranstransferase activity;P:isoprenoid biosynthetic process;C:chloroplast;OBFPMAVO.I.H.G.
At3g14550820681GGPS3 (GERANYLGERANYL PYROPHOSPHATE SYNTHASE 3)Encodes a protein with geranylgeranyl pyrophosphate synthase activity involved in isoprenoid biosynthesis. The enzyme appears to be targeted to the chloroplast in epidermal cells and guard cells of leaves, and in etioplasts in roots.O.I.H.G.
At3g15020820731malate dehydrogenase (NAD), mitochondrial, putativeF:in 6 functions;P:defense response to bacterium;C:mitochondrion, apoplast, membrane;BOMPFAO.I.H.G.
At3g16950820951LPD1 (LIPOAMIDE DEHYDROGENASE 1)encodes a plastid lipoamide dehydrogenase, subunit of the pyruvate dehydrogenase complex which provides acetyl-CoA for de novo fatty acid biosynthesis. The gene is highly expressed in developing seeds.O.I.H.G.
At3g17240820984mtLPD2 (LIPOAMIDE DEHYDROGENASE 2)lipoamide dehydrogenase precursorO.I.H.G.
At3g19820821519DWF1 (DWARF 1)Involved in the conversion of the early brassinosteroid precursor 24-methylenecholesterol to campesterol. Brassinosteroids affect cellular elongation. Mutants have dwarf phenotype. DWF1 is a Ca2+-dependent calmodulin-binding protein.O.I.H.G.
At3g20160821560geranylgeranyl pyrophosphate synthase, putative / GGPP synthetase, putative / farnesyltranstransferase, putativeF:farnesyltranstransferase activity;P:isoprenoid biosynthetic process;C:unknown;OBFPMAVO.I.H.G.
At3g215008217041-deoxy-D-xylulose-5-phosphate synthaseEncodes a protein postulated to have 1-deoxy-D-xylulose 5-phosphate synthase activity.O.I.H.G.
At3g25960822193pyruvate kinase, putativeF:pyruvate kinase activity, magnesium ion binding, potassium ion binding, catalytic activity;P:glycolysis;C:unknown;BOMPFAO.I.H.G.
At3g26650822277GAPA (GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE A SUBUNIT)Encodes one of the two subunits forming the photosynthetic glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and as such a constituent of the supramolecular complex with phosphoribulokinase (PRK) thought to be linked by a small peptide encoded by CP12-2. GapA-1 is coordinately expressed by light with PRK and CP12-2. The enzyme activity, tested in leaf protein extracts dropped significantly after external sucrose treatment for the photosynthetic GAPDH (NADPH-dependent) but not for the cytosolic GAPDH (NADH-dependent).O.I.H.G.
At3g27380822359SDH2-1One of three isoforms of the iron-sulfur component of the succinate dehydrogenase complex, a component of the mitochondrial respiratory chain complex II. The product of the nuclear encoded gene is imported into the mitochondrion. Expressed during germination and post-germinative growth.O.I.H.G.
At3g29430822604geranylgeranyl pyrophosphate synthase, putative / GGPP synthetase, putative / farnesyltranstransferase, putativeF:unknown;P:isoprenoid biosynthetic process;C:unknown;OBFPMAVO.I.H.G.
At3g32040822957geranylgeranyl pyrophosphate synthase, putative / GGPP synthetase, putative / farnesyltranstransferase, putativeF:unknown;P:isoprenoid biosynthetic process;C:unknown;OBPFMAVO.I.H.G.
At3g45130823649LAS1F:lanosterol synthase activity;P:pentacyclic triterpenoid biosynthetic process;C:cellular_component unknown;BPOFMAO.I.H.G.
At3g47520823906MDH (MALATE DEHYDROGENASE)Encodes a protein with NAD-dependent malate dehydrogenase activity, located in chloroplasts.O.I.H.G.
At3g49160824077pyruvate kinase family proteinExpression of the gene is downregulated in the presence of paraquat, an inducer of photoxidative stress.O.I.H.G.
At3g50520824216phosphoglycerate/bisphosphoglycerate mutase family proteinF:catalytic activity;P:metabolic process;C:cellular_component unknown;BOMFPAO.I.H.G.
At3g52200824385LTA3dihydrolipoamide S-acetyltransferase (LTA3) mRNA, nuclearO.I.H.G.
At3g52930824459fructose-bisphosphate aldolase, putativeF:fructose-bisphosphate aldolase activity, catalytic activity;P:response to cadmium ion, response to salt stress, pentose-phosphate shunt;C:in 7 components;OMBPFO.I.H.G.
At3g52940824460FK (FACKEL)Encodes a sterol C-14 reductase required for cell division and expansion and is involved in proper organization of the embryo.O.I.H.G.
At3g52990824465pyruvate kinase, putativeF:pyruvate kinase activity, potassium ion binding, magnesium ion binding, catalytic activity;P:response to cadmium ion, glycolysis;C:membrane;BOMPFAO.I.H.G.
At3g54250824592mevalonate diphosphate decarboxylase, putativeF:diphosphomevalonate decarboxylase activity, kinase activity, ATP binding;P:isoprenoid biosynthetic process, phosphorylation;C:cellular_component unknown;BOMFPAO.I.H.G.
At3g554108247072-oxoglutarate dehydrogenase E1 component, putative / oxoglutarate decarboxylase, putative / alpha-ketoglutaric dehydrogenase, putativeF:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor, oxoglutarate dehydrogenase (succinyl-transferring) activity, thiamin pyrophosphate binding;P:glycolysis, metabolic process;C:mitochondrion;OBMFPAO.I.H.G.
At3g55650824731pyruvate kinase, putativeF:pyruvate kinase activity, potassium ion binding, magnesium ion binding, catalytic activity;P:glycolysis;C:mitochondrion;BOMPFAO.I.H.G.
At3g55810824747pyruvate kinase, putativeF:pyruvate kinase activity, potassium ion binding, magnesium ion binding, catalytic activity;P:glycolysis;C:unknown;BOMPFAO.I.H.G.
At3g58740825043CSY1 (CITRATE SYNTHASE 1)Encodes a peroxisomal citrate synthase that is expressed in siliques and developing seeds.O.I.H.G.
At3g58750825044CSY2 (citrate synthase 2)Encodes a peroxisomal citrate synthase that is expressed throughout seedling and shoot development.O.I.H.G.
At3g60100825180CSY5 (citrate synthase 5)F:citrate (SI)-synthase activity, transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer;P:cellular carbohydrate metabolic process, tricarboxylic acid cycle;C:mitochondrion;BOMFAPO.I.H.G.
At4g00570828222malate oxidoreductase, putativeF:oxidoreductase activity, acting on NADH or NADPH, NAD or NADP as acceptor, malic enzyme activity, ATP binding;P:oxidation reduction, malate metabolic process, metabolic process;C:mitochondrion, chloroplast;BOMPFAO.I.H.G.
At4g11820826788MVA1Encodes a protein with hydroxymethylglutaryl-CoA synthase activity which was characterized by phenotypical complementation of the S. cerevisiae mutant.O.I.H.G.
At4g15560827230CLA1 (CLOROPLASTOS ALTERADOS 1)Encodes a protein with 1-deoxyxylulose 5-phosphate synthase activity involved in the MEP pathway. It is essential for chloroplast development in ArabidopsisO.I.H.G.
At4g16155827307dihydrolipoyl dehydrogenaseF:dihydrolipoyl dehydrogenase activity;P:cell redox homeostasis;C:chloroplast, chloroplast envelope;BOMAPFO.I.H.G.
At4g17190827430FPS2 (FARNESYL DIPHOSPHATE SYNTHASE 2)Encodes a protein with farnesyl diphosphate synthase activity, which catalyzes the rate limiting step in isoprenoid biosynthesis. Its mRNA is most abundantly expressed in flowers.O.I.H.G.
At4g24620828564PGI1 (PHOSPHOGLUCOSE ISOMERASE 1)The PGI1 gene encodes the plastid phospho-glucose (Glc) isomerase. While pgi1-1 mutant has a deficiency in leaf starch synthesis, it accumulates starch in root cap cells. Flowering time of the pgi1-1 mutant is significantly delayed under short-day conditions.O.I.H.G.
At4g26270828733PFK3 (PHOSPHOFRUCTOKINASE 3)F:6-phosphofructokinase activity;P:glycolysis;C:cytosol, 6-phosphofructokinase complex;BOMFPAVO.I.H.G.
At4g26390828745pyruvate kinase, putativeF:pyruvate kinase activity, potassium ion binding, magnesium ion binding, catalytic activity;P:glycolysis;C:cellular_component unknown;BOMPFAO.I.H.G.
At4g26520828758fructose-bisphosphate aldolase, cytoplasmicF:fructose-bisphosphate aldolase activity;P:pentose-phosphate shunt, response to hypoxia;C:unknown;OMBPFO.I.H.G.
At4g26530828759fructose-bisphosphate aldolase, putativeF:fructose-bisphosphate aldolase activity;P:glycolysis, metabolic process;C:chloroplast;OMBPFO.I.H.G.
At4g269108287982-oxoacid dehydrogenase family proteinF:dihydrolipoyllysine-residue succinyltransferase activity, acyltransferase activity;P:tricarboxylic acid cycle, metabolic process;C:mitochondrion, membrane;OBMFPAVO.I.H.G.
At4g26970828805aconitate hydratase/ copper ion bindingF:aconitate hydratase activity, copper ion binding;P:response to cadmium ion;C:mitochondrion, chloroplast;OBMFAPO.I.H.G.
At4g29130829034HXK1 (HEXOKINASE 1)Encodes a hexokinase (HXK1) in the plant glucose-signaling network. Functions as a glucose sensor to interrelate nutrient, light, and hormone signaling networks for controlling growth and development in response to the changing environment.O.I.H.G.
At4g29220829043PFK1 (PHOSPHOFRUCTOKINASE 1)F:6-phosphofructokinase activity;P:glycolysis;C:cytosol, 6-phosphofructokinase complex, plasma membrane;BOMPFAVO.I.H.G.
At4g32840829420PFK6 (PHOSPHOFRUCTOKINASE 6)F:6-phosphofructokinase activity;P:glycolysis;C:cytosol, 6-phosphofructokinase complex;BOMFPAVO.I.H.G.
At4g34350829585HDR (4-HYDROXY-3-METHYLBUT-2-ENYL DIPHOSPHATE REDUCTASE)Arabidopsis ISPH is involved in the plastid nonmevalonate pathway of isoprenoid biosynthesis. It was shown to complement the lethal phenotype of E. coli ispH mutant and is therefore most likely encodes a protein with 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity involved in the last step of mevalonate-independent isopentenyl biosynthesis. Mutant has Albino seedling.O.I.H.G.
At4g34640829616SQS1 (SQUALENE SYNTHASE 1)Encodes squalene synthase, which converts two molecules of farnesyl diphosphate (FPP) into squalene via an intermediate: presqualene diphosphate (PSPP). It is generally thought to be one of the key enzymes of sterol biosynthesis, since it catalyzes the first pathway-specific reaction of the sterol branch of the isoprenoid pathway.O.I.H.G.
At4g34650829617SQS2 (SQUALENE SYNTHASE 2)Encodes a protein with similarity to squalene synthase which catalyzes the first committed step in sterol biosynthesis. To date no experimental evidence exists that SQS2 functions as a squalene synthase and some experiments indicate it does not have this function.O.I.H.G.
At4g35260829679IDH1 (ISOCITRATE DEHYDROGENASE 1)NAD+ dependent isocitrate dehydrogenase subunit 1 (IDH1)O.I.H.G.
At4g35650829717isocitrate dehydrogenase, putative / NAD+ isocitrate dehydrogenase, putativeF:isocitrate dehydrogenase (NAD+) activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;P:tricarboxylic acid cycle, metabolic process;C:mitochondrion;BOFMAPO.I.H.G.
At4g35830829737aconitate hydratase, cytoplasmic / citrate hydro-lyase / aconitase (ACO)F:aconitate hydratase activity, 4 iron, 4 sulfur cluster binding;P:response to salt stress;C:mitochondrion, apoplast, plasma membrane, vacuole;OBFMAPO.I.H.G.
At4g36810829834GGPS1 (GERANYLGERANYL PYROPHOSPHATE SYNTHASE 1)Encodes a protein with geranylgeranyl pyrophosphate synthase activity involved in isoprenoid biosynthesis. The enzyme appears to be targeted to the chloroplast in epidermal cells and guard cells of leaves, and in etioplasts in roots.O.I.H.G.
At4g37760829932SQE3 (squalene epoxidase 3)F:squalene monooxygenase activity;P:response to jasmonic acid stimulus, sterol biosynthetic process, response to wounding;C:endomembrane system, integral to membrane;BOFMPAO.I.H.G.
At4g37840829940HKL3 (HEXOKINASE-LIKE 3)Encodes a putative hexokinase.O.I.H.G.
At4g38970830052fructose-bisphosphate aldolase, putativeProtein is tyrosine-phosphorylated and its phosphorylation state is modulated in response to ABA in Arabidopsis thaliana seeds.O.I.H.G.
At5g03290831884isocitrate dehydrogenase, putative / NAD+ isocitrate dehydrogenase, putativeF:isocitrate dehydrogenase (NAD+) activity, ATP binding;P:tricarboxylic acid cycle, metabolic process;C:mitochondrion, chloroplast;BOMFAPO.I.H.G.
At5g03690831759fructose-bisphosphate aldolase, putativeF:fructose-bisphosphate aldolase activity, catalytic activity;P:pentose-phosphate shunt;C:unknown;OMBPFO.I.H.G.
At5g08300830726succinyl-CoA ligase (GDP-forming) alpha-chain, mitochondrial, putative / succinyl-CoA synthetase, alpha chain, putative / SCS-alpha, putativeF:succinate-CoA ligase (GDP-forming) activity, metal ion binding;P:response to cadmium ion, metabolic process;C:mitochondrion, cell wall;OBMAFPO.I.H.G.
At5g08570830758pyruvate kinase, putativeF:pyruvate kinase activity, potassium ion binding, magnesium ion binding, catalytic activity;P:glycolysis;C:cellular_component unknown;BOMPFAO.I.H.G.
At5g09660830825PMDH2 (peroxisomal NAD-malate dehydrogenase 2)encodes a microbody NAD-dependent malate dehydrogenase encodes an peroxisomal NAD-malate dehydrogenase that is involved in fatty acid beta-oxidation through providing NAD to the process of converting fatty acyl CoA to acetyl CoA.O.I.H.G.
At5g11380831009DXPS3 (1-deoxy-D-xylulose 5-phosphate synthase 3)Encodes a protein postulated to have 1-deoxy-D-xylulose 5-phosphate synthase activity.O.I.H.G.
At5g11670831039ATNADP-ME2 (NADP-malic enzyme 2)The malic enzyme (EC 1.1.1.40) encoded by AtNADP-ME2 is presumably a cytosolic enzyme involved in malate metabolism and possibly assisting the oxidative pentose phosphate pathway. AtNADP-ME2 counts for the major part of NADP-ME activity in mature tissues of Arabidopsis.O.I.H.G.
At5g14590831311isocitrate dehydrogenase, putative / NADP+ isocitrate dehydrogenase, putativeF:isocitrate dehydrogenase (NADP+) activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;P:isocitrate metabolic process, metabolic process;C:mitochondrion, chloroplast;OBMPFAO.I.H.G.
At5g16440831505IPP1 (ISOPENTENYL DIPHOSPHATE ISOMERASE 1)Encodes a protein with isopentenyl diphosphate:dimethylallyl diphosphate isomerase activity. There is genetic evidence that it functions in the mevalonate, but not the MEP biosynthetic pathway.O.I.H.G.
At5g23250832389succinyl-CoA ligase (GDP-forming) alpha-chain, mitochondrial, putative / succinyl-CoA synthetase, alpha chain, putative / SCS-alpha, putativeF:succinate-CoA ligase (ADP-forming) activity, succinate-CoA ligase (GDP-forming) activity, binding, ATP citrate synthase activity, catalytic activity;P:metabolic process;C:mitochondrion;OBMAFPO.I.H.G.
At5g24140832479SQP2Encodes a protein with similarity to squalene monoxygenases.O.I.H.G.
At5g25880832657ATNADP-ME3 (NADP-malic enzyme 3)The malic enzyme (EC 1.1.1.40) encoded by the ATNADP-ME3 is presumably cytosolic and restricted in its expression by both developmental and cell-specific signals.O.I.H.G.
At5g27450832804MK (MEVALONATE KINASE)Encodes a protein with mevalonate kinase activity involved in the mevalonate pathway.O.I.H.G.
At5g40650834065SDH2-2One of three isoforms of the iron-sulfur component of the succinate dehydrogenase complex, a component of the mitochondrial respiratory chain complex II. The product of the nuclear encoded gene is imported into the mitochondrion. Expressed during germination and post-germinative growth.O.I.H.G.
At5g42740834283glucose-6-phosphate isomerase, cytosolic (PGIC)F:glucose-6-phosphate isomerase activity;P:response to cadmium ion, gluconeogenesis, glycolysis;C:cellular_component unknown;BOPMFAO.I.H.G.
At5g43330834351malate dehydrogenase, cytosolic, putativeF:in 6 functions;P:cellular carbohydrate metabolic process, glycolysis, malate metabolic process, carbohydrate metabolic process, metabolic process;C:plasma membrane;BOMPFAO.I.H.G.
At5g47770834828FPS1 (FARNESYL DIPHOSPHATE SYNTHASE 1)Encodes a protein with farnesyl diphosphate synthase activity.O.I.H.G.
At5g49460835006ACLB-2 (ATP CITRATE LYASE SUBUNIT B 2)One of the two genes encoding subunit B of the cytosolic enzyme ATP Citrate Lyase (ACL)O.I.H.G.
At5g50850835157MAB1 (MACCI-BOU)F:pyruvate dehydrogenase (acetyl-transferring) activity, catalytic activity;P:defense response to bacterium;C:mitochondrion, nucleolus, plasma membrane;BOMPFAO.I.H.G.
At5g50950835168fumarate hydratase, putative / fumarase, putativeF:fumarate hydratase activity, catalytic activity;P:response to salt stress;C:mitochondrion;BOMAFPO.I.H.G.
At5g52920835369PKP-BETA1 (PLASTIDIC PYRUVATE KINASE BETA SUBUNIT 1)encodes a dominant chloroplast pyruvate kinase beta subunit. Important for seed oil biosynthesis. Ubiquitously expressed, with significantly increased expression in maturing seeds. The mutant plant has wrinkled seeds, with a 50-70% reduction in seed fatty acid content.O.I.H.G.
At5g550708355982-oxoacid dehydrogenase family proteinF:dihydrolipoyllysine-residue succinyltransferase activity, acyltransferase activity;P:response to oxidative stress, metabolic process;C:cytosolic ribosome, mitochondrion;BOMPFVAO.I.H.G.
At5g56350835735pyruvate kinase, putativeF:pyruvate kinase activity, potassium ion binding, magnesium ion binding, catalytic activity;P:glycolysis;C:cellular_component unknown;BOMPFAO.I.H.G.
At5g56630835764PFK7 (PHOSPHOFRUCTOKINASE 7)F:6-phosphofructokinase activity;P:glycolysis;C:cytosol, 6-phosphofructokinase complex;BOMFPAVO.I.H.G.
At5g56720835773malate dehydrogenase, cytosolic, putativeF:in 6 functions;P:cellular carbohydrate metabolic process, glycolysis, malate metabolic process, carbohydrate metabolic process, metabolic process;C:membrane;BOMPFAO.I.H.G.
At5g58330835945malate dehydrogenase (NADP), chloroplast, putativeF:oxidoreductase activity, binding, malate dehydrogenase activity, catalytic activity, malate dehydrogenase (NADP+) activity;P:malate metabolic process, carbohydrate metabolic process, metabolic process;C:in 6 components;BOMPFAO.I.H.G.
At5g60600836181HDS (4-HYDROXY-3-METHYLBUT-2-ENYL DIPHOSPHATE SYNTHASE)Encodes a chloroplast-localized hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) synthase (HDS), catalyzes the formation of HMBPP from 2-C-methyl-D-erythrytol 2,4-cyclodiphosphate (MEcPP). The HDS enzyme controls the penultimate steps of the biosynthesis of IPP and dimethylallyl diphosphate (DMAPP) via the MEP pathway and may serve as a metabolic control point for SA-mediated disease resistance. In the light, the electrons required for the reaction catalyzed by HDS are directly provided by the electron flow from photosynthesis via ferredoxin. In the dark however, the enzyme requires an electron shuttle: ferredoxin-NADP+ reductase.O.I.H.G.
At5g61580836279PFK4 (PHOSPHOFRUCTOKINASE 4)F:6-phosphofructokinase activity;P:glycolysis;C:6-phosphofructokinase complex, chloroplast;BOMPFAVO.I.H.G.
At5g62790836400DXR (1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE)1-Deoxy-d-xylulose 5-phosphate reductoisomerase (DXR) catalyzes the first committed step of the 2-C-methyl-d-erythritol 4-phosphate pathway for isoprenoid biosynthesis. In Arabidopsis, DXR is encoded by a single-copy gene. Arabidopsis DXR is targeted to plastids and localizes into chloroplasts of leaf cells. DXR knockout or strongly silenced lines have a seedling lethal, albino phenotype. Transgenic, partially silenced lines expressing 35S:DXR have a variegated phenotype.O.I.H.G.
At5g63680836488pyruvate kinase, putativeF:pyruvate kinase activity, potassium ion binding, magnesium ion binding, catalytic activity;P:response to cadmium ion, glycolysis;C:plasma membrane;BOMPFAO.I.H.G.
At5g65165836640SDH2-3One of three isoforms of the iron-sulfur component of the succinate dehydrogenase complex, a component of the mitochondrial respiratory chain complex II. The product of the nuclear encoded gene is imported into the mitochondrion. Transcripts appear during seed maturation, persist through dessication, are abundant in dry seeds, and markedly decline during germination.O.I.H.G.
At5g657508367042-oxoglutarate dehydrogenase E1 component, putative / oxoglutarate decarboxylase, putative / alpha-ketoglutaric dehydrogenase, putativeF:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor, oxoglutarate dehydrogenase (succinyl-transferring) activity, thiamin pyrophosphate binding;P:response to cadmium ion;C:mitochondrion;OBMFPAO.I.H.G.
At5g66760836809SDH1-1One of two genes in Arabidopsis that encode a flavoprotein subunit of the mitochondrial succinate dehydrogenase complex.O.I.H.G.

Comparison with co-expressed genes



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