Metabolic pathway to genes

Genes assigned in the pathway

Query pathway ID 00900
Pathway name Terpenoid backbone biosynthesis
Organism Arabidopsis_thaliana
Database KEGG PATHWAY

Click Gene ID to show a list of co-expressed genes.

Gene ID Repr. ID Gene name Functional description O.I. H.G. Other DB
At1g17050838275SPS2 (Solanesyl diphosphate synthase 2)Encodes a protein with solanesyl diphosphate synthase activity.O.I.H.G.
At1g31910840081GHMP kinase family proteinF:kinase activity, ATP binding;P:phosphorylation;C:unknown;FPOBAO.I.H.G.
At1g49530841377GGPS6 (geranylgeranyl pyrophosphate synthase 6)encodes a mitochondria-targeted geranylgeranyl pyrophosphate synthaseO.I.H.G.
At1g63970842700ISPFEncodes a protein with 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity. The protein's activity was confirmed by heterologous expression of phenotypic complementation of the E. coli ispF mutant. Plants defective in this gene display an albino lethal phenotype.Homolog of E. coli IspFO.I.H.G.
At1g74470843788geranylgeranyl reductaseEncodes for a multifunctional protein with geranylgeranyl reductase activity shown to catalyze the reduction of prenylated geranylgeranyl-chlorophyll a to phytyl-chlorophyll a (chlorophyll a) and free geranylgeranyl pyrophosphate to phytyl pyrophosphate.O.I.H.G.
At1g76490843982HMG1 (HYDROXY METHYLGLUTARYL COA REDUCTASE 1)Encodes a 3-hydroxy-3-methylglutaryl coenzyme A reductase, which is involved in melavonate biosynthesis and performs the first committed step in isoprenoid biosynthesis. Expression is activated in dark in leaf tissue but not controlled by light in the root (confineO.I.H.G.
At1g78510844187SPS1 (solanesyl diphosphate synthase 1)Encodes a protein with solanesyl diphosphate synthase activity.O.I.H.G.
At2g02500814779ISPDEncodes a protein with 4-Diphosphocytidyl-2C-methyl-D-erythritol synthase activity. The enzyme has an absolute requirement for divalent cations (Mg2+ reaches the highest catalytic activity).O.I.H.G.
At2g17370816244HMG2 (3-HYDROXY-3-METHYLGLUTARYL-COA REDUCTASE 2)Encodes a 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) that is involved in the synthesis of sterol and triterpenoid compounds.O.I.H.G.
At2g17570816264undecaprenyl pyrophosphate synthetase family protein / UPP synthetase family proteinF:transferase activity, transferring alkyl or aryl (other than methyl) groups;P:unknown;C:unknown;OBMAFPO.I.H.G.
At2g18620816377geranylgeranyl pyrophosphate synthase, putative / GGPP synthetase, putative / farnesyltranstransferase, putativeF:unknown;P:isoprenoid biosynthetic process;C:unknown;OBPFAMVO.I.H.G.
At2g18640816379GGPS4 (GERANYLGERANYL PYROPHOSPHATE SYNTHASE 4)Encodes an endoplasmic reticulum-targeted geranylgeranyl pyrophosphate synthaseO.I.H.G.
At2g23410816873ACPT (Arabidopsis cis-prenyltransferase)encodes cis-prenyltransferaseO.I.H.G.
At2g23800816912GGPS2 (GERANYLGERANYL PYROPHOSPHATE SYNTHASE 2)encodes an endoplasmic reticulum-targeted geranylgeranyl pyrophosphate synthaseO.I.H.G.
At2g26930817234ATCDPMEK (4-(CYTIDINE 5'-PHOSPHO)-2-C-METHYL-D-ERITHRITOL KINASE)Encodes a 4-(cytidine 5'-phospho)-2-C-methyl-D-erithritol kinase.O.I.H.G.
At2g38700818452MVD1 (MEVALONATE DIPHOSPHATE DECARBOXYLASE 1)Encodes mevalonate diphosphate decarboxylase, the enzyme that catalyzes the synthesis of isopentenyl diphosphate, used in sterol and isoprenoid biosynthesis. The protein appears to form a homodimeric complex. Incidentally, it was shown that the Arabidopsis MVD protein could also interact with its yeast homolog to form a heterodimer.O.I.H.G.
At3g02780820960IPP2 (ISOPENTENYL PYROPHOSPHATE:DIMETHYLALLYL PYROPHOSPHATE ISOMERASE 2)Encodes a protein with isopentenyl diphosphate:dimethylallyl diphosphate isomerase activity. There is genetic evidence that it functions in the mevalonate, but not the MEP biosynthetic pathway.O.I.H.G.
At3g14510820674geranylgeranyl pyrophosphate synthase, putative / GGPP synthetase, putative / farnesyltranstransferase, putativeF:unknown;P:isoprenoid biosynthetic process;C:unknown;OBFPMAVO.I.H.G.
At3g14530820678geranylgeranyl pyrophosphate synthase, putative / GGPP synthetase, putative / farnesyltranstransferase, putativeF:farnesyltranstransferase activity;P:isoprenoid biosynthetic process;C:chloroplast;OBFPMAVO.I.H.G.
At3g14550820681GGPS3 (GERANYLGERANYL PYROPHOSPHATE SYNTHASE 3)Encodes a protein with geranylgeranyl pyrophosphate synthase activity involved in isoprenoid biosynthesis. The enzyme appears to be targeted to the chloroplast in epidermal cells and guard cells of leaves, and in etioplasts in roots.O.I.H.G.
At3g20160821560geranylgeranyl pyrophosphate synthase, putative / GGPP synthetase, putative / farnesyltranstransferase, putativeF:farnesyltranstransferase activity;P:isoprenoid biosynthetic process;C:unknown;OBFPMAVO.I.H.G.
At3g215008217041-deoxy-D-xylulose-5-phosphate synthaseEncodes a protein postulated to have 1-deoxy-D-xylulose 5-phosphate synthase activity.O.I.H.G.
At3g29430822604geranylgeranyl pyrophosphate synthase, putative / GGPP synthetase, putative / farnesyltranstransferase, putativeF:unknown;P:isoprenoid biosynthetic process;C:unknown;OBFPMAVO.I.H.G.
At3g32040822957geranylgeranyl pyrophosphate synthase, putative / GGPP synthetase, putative / farnesyltranstransferase, putativeF:unknown;P:isoprenoid biosynthetic process;C:unknown;OBPFMAVO.I.H.G.
At3g54250824592mevalonate diphosphate decarboxylase, putativeF:diphosphomevalonate decarboxylase activity, kinase activity, ATP binding;P:isoprenoid biosynthetic process, phosphorylation;C:cellular_component unknown;BOMFPAO.I.H.G.
At4g11820826788MVA1Encodes a protein with hydroxymethylglutaryl-CoA synthase activity which was characterized by phenotypical complementation of the S. cerevisiae mutant.O.I.H.G.
At4g15560827230CLA1 (CLOROPLASTOS ALTERADOS 1)Encodes a protein with 1-deoxyxylulose 5-phosphate synthase activity involved in the MEP pathway. It is essential for chloroplast development in ArabidopsisO.I.H.G.
At4g17190827430FPS2 (FARNESYL DIPHOSPHATE SYNTHASE 2)Encodes a protein with farnesyl diphosphate synthase activity, which catalyzes the rate limiting step in isoprenoid biosynthesis. Its mRNA is most abundantly expressed in flowers.O.I.H.G.
At4g34350829585HDR (4-HYDROXY-3-METHYLBUT-2-ENYL DIPHOSPHATE REDUCTASE)Arabidopsis ISPH is involved in the plastid nonmevalonate pathway of isoprenoid biosynthesis. It was shown to complement the lethal phenotype of E. coli ispH mutant and is therefore most likely encodes a protein with 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity involved in the last step of mevalonate-independent isopentenyl biosynthesis. Mutant has Albino seedling.O.I.H.G.
At4g36810829834GGPS1 (GERANYLGERANYL PYROPHOSPHATE SYNTHASE 1)Encodes a protein with geranylgeranyl pyrophosphate synthase activity involved in isoprenoid biosynthesis. The enzyme appears to be targeted to the chloroplast in epidermal cells and guard cells of leaves, and in etioplasts in roots.O.I.H.G.
At5g11380831009DXPS3 (1-deoxy-D-xylulose 5-phosphate synthase 3)Encodes a protein postulated to have 1-deoxy-D-xylulose 5-phosphate synthase activity.O.I.H.G.
At5g16440831505IPP1 (ISOPENTENYL DIPHOSPHATE ISOMERASE 1)Encodes a protein with isopentenyl diphosphate:dimethylallyl diphosphate isomerase activity. There is genetic evidence that it functions in the mevalonate, but not the MEP biosynthetic pathway.O.I.H.G.
At5g27450832804MK (MEVALONATE KINASE)Encodes a protein with mevalonate kinase activity involved in the mevalonate pathway.O.I.H.G.
At5g47770834828FPS1 (FARNESYL DIPHOSPHATE SYNTHASE 1)Encodes a protein with farnesyl diphosphate synthase activity.O.I.H.G.
At5g48230834876ACAT2 (ACETOACETYL-COA THIOLASE 2)F:acetyl-CoA C-acetyltransferase activity, catalytic activity;P:embryonic development ending in seed dormancy;C:peroxisome, plasma membrane;BOMFAPO.I.H.G.
At5g58770835991dehydrodolichyl diphosphate synthase, putative / DEDOL-PP synthase, putativeF:dehydrodolichyl diphosphate synthase activity;P:dolichol biosynthetic process;C:chloroplast;OBAFMPO.I.H.G.
At5g58780835992dehydrodolichyl diphosphate synthase, putative / DEDOL-PP synthase, putativeF:dehydrodolichyl diphosphate synthase activity;P:dolichol biosynthetic process;C:endomembrane system;OBAFMPO.I.H.G.
At5g58782835993dehydrodolichyl diphosphate synthase, putative / DEDOL-PP synthase, putativeF:dehydrodolichyl diphosphate synthase activity;P:dolichol biosynthetic process;C:endomembrane system;OBAFMPO.I.H.G.
At5g58784835994dehydrodolichyl diphosphate synthaseF:dehydrodolichyl diphosphate synthase activity;P:dolichol biosynthetic process;C:endomembrane system;OBAFMPO.I.H.G.
At5g60600836181HDS (4-HYDROXY-3-METHYLBUT-2-ENYL DIPHOSPHATE SYNTHASE)Encodes a chloroplast-localized hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) synthase (HDS), catalyzes the formation of HMBPP from 2-C-methyl-D-erythrytol 2,4-cyclodiphosphate (MEcPP). The HDS enzyme controls the penultimate steps of the biosynthesis of IPP and dimethylallyl diphosphate (DMAPP) via the MEP pathway and may serve as a metabolic control point for SA-mediated disease resistance. In the light, the electrons required for the reaction catalyzed by HDS are directly provided by the electron flow from photosynthesis via ferredoxin. In the dark however, the enzyme requires an electron shuttle: ferredoxin-NADP+ reductase.O.I.H.G.
At5g62790836400DXR (1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE)1-Deoxy-d-xylulose 5-phosphate reductoisomerase (DXR) catalyzes the first committed step of the 2-C-methyl-d-erythritol 4-phosphate pathway for isoprenoid biosynthesis. In Arabidopsis, DXR is encoded by a single-copy gene. Arabidopsis DXR is targeted to plastids and localizes into chloroplasts of leaf cells. DXR knockout or strongly silenced lines have a seedling lethal, albino phenotype. Transgenic, partially silenced lines expressing 35S:DXR have a variegated phenotype.O.I.H.G.

Comparison with co-expressed genes



Back to the CoP portal site

Back to the KAGIANA project homepage