Metabolic pathway to genes

Genes assigned in the pathway

Query pathway ID 00620
Pathway name Pyruvate metabolism
Organism Arabidopsis_thaliana
Database KEGG PATHWAY

Click Gene ID to show a list of co-expressed genes.

Gene ID Repr. ID Gene name Functional description O.I. H.G. Other DB
At1g01090839429PDH-E1 ALPHA (PYRUVATE DEHYDROGENASE E1 ALPHA)pyruvate dehydrogenase E1 alpha subunitO.I.H.G.
At1g04410839527malate dehydrogenase, cytosolic, putativeF:in 6 functions;P:response to cadmium ion, response to salt stress;C:in 7 components;BOMPFAO.I.H.G.
At1g08110837330lactoylglutathione lyase, putative / glyoxalase I, putativeF:calmodulin binding, lactoylglutathione lyase activity;P:response to cadmium ion, carbohydrate metabolic process;C:chloroplast;BOFPMAO.I.H.G.
At1g18500838431MAML-4 (METHYLTHIOALKYLMALATE SYNTHASE-LIKE 4)Encodes an active Arabidopsis isopropylmalate synthase IPMS1. Involved in leucine biosynthesis. Do not participate in the chain elongation of glucosinolates. Expressed constitutively throughout the plant. Loss of IPMS1 can be compensated by a second isopropylmalate synthase gene IPMS2 (At1g74040).O.I.H.G.
At1g23800838991ALDH2B7Encodes a mitochondrial aldehyde dehydrogenase; nuclear gene for mitochondrial product.O.I.H.G.
At1g24180839031IAR4Arabidopsis thaliana pyruvate dehydrogenase E1a-like subunit. 81% identical to a previously characterized Arabidopsis mitochondrial PDH E1a-subunit, At1g59900O.I.H.G.
At1g30120839891PDH-E1 BETA (PYRUVATE DEHYDROGENASE E1 BETA)Encodes a putative plastid pyruvate dehydrogenase E1 beta subunit that is distinct from the mitochondrial pyruvate dehydrogenase E1 beta subunit.O.I.H.G.
At1g32440840138PKp3 (plastidial pyruvate kinase 3)encodes a chloroplast pyruvate kinase beta subunit. The enzyme is less active than the other chloroplast pyruvate kinase beta subunit encoded by AT5G52920. Involved in seed oil biosynthesis. Can partially complement the AT5G52920 mutant.O.I.H.G.
At1g34430840346EMB3003 (embryo defective 3003)F:dihydrolipoyllysine-residue acetyltransferase activity, protein binding, acyltransferase activity;P:embryonic development ending in seed dormancy;C:cytosolic ribosome, plasma membrane, chloroplast, chloroplast envelope;OBMFPAO.I.H.G.
At1g36160840521ACC1 (ACETYL-COENZYME A CARBOXYLASE 1)Encodes acetyl-CoA carboxylase. Mutant displays uncoordinated cell divisions which are enhanced by cytokinins. Mutant also has aberrant organization of the apical region in the embryo and abnormal root and shoot development. Essential for very long chain fatty acid elongation.O.I.H.G.
At1g48030841221mtLPD1 (mitochondrial lipoamide dehydrogenase 1)Encodes a mitochondrial lipoamide dehydrogenase whose expression is induced by light.O.I.H.G.
At1g53240841757malate dehydrogenase (NAD), mitochondrialF:malate dehydrogenase activity;P:response to cadmium ion, response to salt stress, response to cold, defense response to bacterium, peptidyl-cysteine S-nitrosylation;C:mitochondrion, cell wall, chloroplast;BOMPFAO.I.H.G.
At1g53310841765ATPPC1 (PHOSPHOENOLPYRUVATE CARBOXYLASE 1)Encodes one of four Arabidopsis phosphoenolpyruvate carboxylase proteins.O.I.H.G.
At1g54100841849ALDH7B4 (Aldehyde Dehydrogenase 7B4)Aldehyde dehydrogenaseO.I.H.G.
At1g54220841863dihydrolipoamide S-acetyltransferase, putativeF:dihydrolipoyllysine-residue acetyltransferase activity, protein binding, acyltransferase activity;P:pyruvate metabolic process, metabolic process, acetyl-CoA biosynthetic process from pyruvate;C:mitochondrion;OBMFPAO.I.H.G.
At1g59900842284AT-E1 ALPHAencodes the e1 alpha subunit of the pyruvate dehydrogenase complex (PDC)O.I.H.G.
At1g68750843206ATPPC4Encodes one of four Arabidopsis phosphoenolpyruvate carboxylase proteins.O.I.H.G.
At1g74040843742IMS1 (2-ISOPROPYLMALATE SYNTHASE 1)Encodes an active Arabidopsis isopropylmalate synthase IPMS2. Involved in leucine biosynthesis. Do not participate in the chain elongation of glucosinolates. Expressed constitutively throughout the plant. Loss of IPMS2 can be compensated by a second isopropylmalate synthase gene IPMS1 (At1g18500).O.I.H.G.
At1g79750844314ATNADP-ME4 (NADP-malic enzyme 4)The malic enzyme (EC 1.1.1.40) encoded by AtNADP-ME4 is localized to chloroplasts. The gene is expressed throughout the whole plant and during embryogenesis and germination. A possible involvement in the fatty acid biosynthesis has been proposed.O.I.H.G.
At2g19900816509ATNADP-ME1 (NADP-malic enzyme 1)The malic enzyme (EC 1.1.1.40) encoded by AtNADP-ME1 is expressed in response to developmental and cell-specific signals.O.I.H.G.
At2g22780816808PMDH1 (PEROXISOMAL NAD-MALATE DEHYDROGENASE 1)encodes an peroxisomal NAD-malate dehydrogenase that is involved in fatty acid beta-oxidation through providing NAD to the process of converting fatty acyl CoA to acetyl CoA.O.I.H.G.
At2g34590818024transketolase family proteinF:pyruvate dehydrogenase (acetyl-transferring) activity, transketolase activity;P:pollen tube development;C:chloroplast, chloroplast envelope;BOMPFAO.I.H.G.
At2g38040818382CAC3encodes the carboxyltransferase alpha subunit of acetyl-CoA carboxylase, involved in de novo fatty acid biosynthesisO.I.H.G.
At2g42600818860ATPPC2 (PHOSPHOENOLPYRUVATE CARBOXYLASE 2)Encodes one of four Arabidopsis phosphoenolpyruvate carboxylase proteins.O.I.H.G.
At3g04050819560pyruvate kinase, putativeF:pyruvate kinase activity, magnesium ion binding, potassium ion binding, catalytic activity;P:glycolysis;C:cellular_component unknown;BOMPFAO.I.H.G.
At3g13930820606dihydrolipoamide S-acetyltransferase, putativeF:dihydrolipoyllysine-residue acetyltransferase activity, protein binding, acyltransferase activity;P:pyruvate metabolic process, metabolic process;C:mitochondrion, chloroplast, chloroplast envelope;OBMFPAO.I.H.G.
At3g14940820723ATPPC3 (PHOSPHOENOLPYRUVATE CARBOXYLASE 3)One of four genes encoding phosphoenolpyruvate carboxylase, its mRNA is most abundantly expressed in roots and siliques.O.I.H.G.
At3g15020820731malate dehydrogenase (NAD), mitochondrial, putativeF:in 6 functions;P:defense response to bacterium;C:mitochondrion, apoplast, membrane;BOMPFAO.I.H.G.
At3g16950820951LPD1 (LIPOAMIDE DEHYDROGENASE 1)encodes a plastid lipoamide dehydrogenase, subunit of the pyruvate dehydrogenase complex which provides acetyl-CoA for de novo fatty acid biosynthesis. The gene is highly expressed in developing seeds.O.I.H.G.
At3g17240820984mtLPD2 (LIPOAMIDE DEHYDROGENASE 2)lipoamide dehydrogenase precursorO.I.H.G.
At3g25960822193pyruvate kinase, putativeF:pyruvate kinase activity, magnesium ion binding, potassium ion binding, catalytic activity;P:glycolysis;C:unknown;BOMPFAO.I.H.G.
At3g47520823906MDH (MALATE DEHYDROGENASE)Encodes a protein with NAD-dependent malate dehydrogenase activity, located in chloroplasts.O.I.H.G.
At3g48000823955ALDH2B4 (ALDEHYDE DEHYDROGENASE 2B4)Encodes a putative (NAD+) aldehyde dehydrogenase.O.I.H.G.
At3g49160824077pyruvate kinase family proteinExpression of the gene is downregulated in the presence of paraquat, an inducer of photoxidative stress.O.I.H.G.
At3g52200824385LTA3dihydrolipoamide S-acetyltransferase (LTA3) mRNA, nuclearO.I.H.G.
At3g52990824465pyruvate kinase, putativeF:pyruvate kinase activity, potassium ion binding, magnesium ion binding, catalytic activity;P:response to cadmium ion, glycolysis;C:membrane;BOMPFAO.I.H.G.
At3g55650824731pyruvate kinase, putativeF:pyruvate kinase activity, potassium ion binding, magnesium ion binding, catalytic activity;P:glycolysis;C:mitochondrion;BOMPFAO.I.H.G.
At3g55810824747pyruvate kinase, putativeF:pyruvate kinase activity, potassium ion binding, magnesium ion binding, catalytic activity;P:glycolysis;C:unknown;BOMPFAO.I.H.G.
At4g00570828222malate oxidoreductase, putativeF:oxidoreductase activity, acting on NADH or NADPH, NAD or NADP as acceptor, malic enzyme activity, ATP binding;P:oxidation reduction, malate metabolic process, metabolic process;C:mitochondrion, chloroplast;BOMPFAO.I.H.G.
At4g09520826536catalytic/ metal ion binding / phosphoglycerate mutaseF:phosphoglycerate mutase activity, catalytic activity, metal ion binding;P:metabolic process;C:cellular_component unknown;BAOPO.I.H.G.
At4g15530827226PPDK (pyruvate orthophosphate dikinase)The product of this long transcript was shown to be targeted to the chloroplast, whereas the shorter transcript (no targeting sequence) accumulates in the cytosol. They were also found in slightly different tissues.O.I.H.G.
At4g16155827307dihydrolipoyl dehydrogenaseF:dihydrolipoyl dehydrogenase activity;P:cell redox homeostasis;C:chloroplast, chloroplast envelope;BOMAPFO.I.H.G.
At4g17260827440L-lactate dehydrogenase, putativeF:in 6 functions;P:response to salt stress, response to abscisic acid stimulus;C:plasma membrane;BOMFPAO.I.H.G.
At4g26390828745pyruvate kinase, putativeF:pyruvate kinase activity, potassium ion binding, magnesium ion binding, catalytic activity;P:glycolysis;C:cellular_component unknown;BOMPFAO.I.H.G.
At4g34240829573ALDH3I1 (ALDEHYDE DEHYDROGENASE 3|1)Aldehyde dehydrogenase induced by ABA and dehydrationO.I.H.G.
At4g37870829943PCK1 (PHOSPHOENOLPYRUVATE CARBOXYKINASE 1)Encodes a putative phosphoenolpyruvate carboxykinase (ATP-dependent).O.I.H.G.
At5g03370831859acylphosphatase familyF:acylphosphatase activity;P:biological_process unknown;C:unknown;BOMAPFO.I.H.G.
At5g03860831690MLS (MALATE SYNTHASE)Encodes a protein with malate synthase activity.O.I.H.G.
At5g08570830758pyruvate kinase, putativeF:pyruvate kinase activity, potassium ion binding, magnesium ion binding, catalytic activity;P:glycolysis;C:cellular_component unknown;BOMPFAO.I.H.G.
At5g09660830825PMDH2 (peroxisomal NAD-malate dehydrogenase 2)encodes a microbody NAD-dependent malate dehydrogenase encodes an peroxisomal NAD-malate dehydrogenase that is involved in fatty acid beta-oxidation through providing NAD to the process of converting fatty acyl CoA to acetyl CoA.O.I.H.G.
At5g11670831039ATNADP-ME2 (NADP-malic enzyme 2)The malic enzyme (EC 1.1.1.40) encoded by AtNADP-ME2 is presumably a cytosolic enzyme involved in malate metabolism and possibly assisting the oxidative pentose phosphate pathway. AtNADP-ME2 counts for the major part of NADP-ME activity in mature tissues of Arabidopsis.O.I.H.G.
At5g16390831500CAC1 (CHLOROPLASTIC ACETYLCOENZYME A CARBOXYLASE 1)Encodes for the biotin carboxyl-carrier subunit of the multi-enzyme plastidial acetyl-coenzyme A carboxylase complex.O.I.H.G.
At5g23010832365MAM1 (METHYLTHIOALKYLMALATE SYNTHASE 1)Encodes a methylthioalkylmalate synthase, catalyzes the condensation reactions of the first two rounds of methionine chain elongation in the biosynthesis of methionine-derived glucosinolates.O.I.H.G.
At5g23020832366IMS2 (2-ISOPROPYLMALATE SYNTHASE 2)methylthioalkymalate synthase-like. Also known as 2-isopropylmalate synthase (IMS2). encodes a methylthioalkylmalate synthase involved in the biosynthesis of aliphatic glucosinolates which accepts all the omega-methylthio-2-oxoalkanoic acids needed to form the known C3 to C8 glucosinolates in Arabidopsis.O.I.H.G.
At5g25880832657ATNADP-ME3 (NADP-malic enzyme 3)The malic enzyme (EC 1.1.1.40) encoded by the ATNADP-ME3 is presumably cytosolic and restricted in its expression by both developmental and cell-specific signals.O.I.H.G.
At5g36880833655acetyl-CoA synthetase, putative / acetate-CoA ligase, putativeF:acetate-CoA ligase activity, catalytic activity, AMP binding;P:metabolic process;C:cytosol, chloroplast stroma, chloroplast;BOMFPAVO.I.H.G.
At5g43330834351malate dehydrogenase, cytosolic, putativeF:in 6 functions;P:cellular carbohydrate metabolic process, glycolysis, malate metabolic process, carbohydrate metabolic process, metabolic process;C:plasma membrane;BOMPFAO.I.H.G.
At5g48230834876ACAT2 (ACETOACETYL-COA THIOLASE 2)F:acetyl-CoA C-acetyltransferase activity, catalytic activity;P:embryonic development ending in seed dormancy;C:peroxisome, plasma membrane;BOMFAPO.I.H.G.
At5g50850835157MAB1 (MACCI-BOU)F:pyruvate dehydrogenase (acetyl-transferring) activity, catalytic activity;P:defense response to bacterium;C:mitochondrion, nucleolus, plasma membrane;BOMPFAO.I.H.G.
At5g52920835369PKP-BETA1 (PLASTIDIC PYRUVATE KINASE BETA SUBUNIT 1)encodes a dominant chloroplast pyruvate kinase beta subunit. Important for seed oil biosynthesis. Ubiquitously expressed, with significantly increased expression in maturing seeds. The mutant plant has wrinkled seeds, with a 50-70% reduction in seed fatty acid content.O.I.H.G.
At5g56350835735pyruvate kinase, putativeF:pyruvate kinase activity, potassium ion binding, magnesium ion binding, catalytic activity;P:glycolysis;C:cellular_component unknown;BOMPFAO.I.H.G.
At5g56720835773malate dehydrogenase, cytosolic, putativeF:in 6 functions;P:cellular carbohydrate metabolic process, glycolysis, malate metabolic process, carbohydrate metabolic process, metabolic process;C:membrane;BOMPFAO.I.H.G.
At5g58330835945malate dehydrogenase (NADP), chloroplast, putativeF:oxidoreductase activity, binding, malate dehydrogenase activity, catalytic activity, malate dehydrogenase (NADP+) activity;P:malate metabolic process, carbohydrate metabolic process, metabolic process;C:in 6 components;BOMPFAO.I.H.G.
At5g63680836488pyruvate kinase, putativeF:pyruvate kinase activity, potassium ion binding, magnesium ion binding, catalytic activity;P:response to cadmium ion, glycolysis;C:plasma membrane;BOMPFAO.I.H.G.
At5g65690836696PCK2 (PHOSPHOENOLPYRUVATE CARBOXYKINASE 2)Encodes a putative phosphoenolpyruvate carboxykinase (ATP-dependent).O.I.H.G.

Comparison with co-expressed genes



Back to the CoP portal site

Back to the KAGIANA project homepage