Metabolic pathway to genes

Genes assigned in the pathway

Query pathway ID 00592
Pathway name alpha-Linolenic acid metabolism
Organism Arabidopsis_thaliana
Database KEGG PATHWAY

Click Gene ID to show a list of co-expressed genes.

Gene ID Repr. ID Gene name Functional description O.I. H.G. Other DB
At1g04710839434PKT4 (PEROXISOMAL 3-KETOACYL-COA THIOLASE 4)EC2.3.1.16 thiolase.O.I.H.G.
At1g06290837140ACX3 (ACYL-COA OXIDASE 3)Encodes an acyl-CoA oxidase with specificity for medium chain fatty acids.O.I.H.G.
At1g06310837141ACX6 (ACYL-COA OXIDASE 6)Encodes a putative acyl-CoA oxidase. However, no transcripts have been detected for this gene and no altered phenotypes have been detected in plants mutant for this gene. This suggests that ACX6 does not significantly contribute to seedling beta-oxidation of fatty acids or indole-3-butyric acid in vivo.O.I.H.G.
At1g13280837888AOC4 (ALLENE OXIDE CYCLASE 4)Encodes allene oxide cyclase. One of four genes in Arabidopsis that encode this enzyme, which catalyzes an essential step in jasmonic acid biosynthesis. Gene expression is reduced during senescence, a process that involves jasmonic acid signalling pathway.O.I.H.G.
At1g17420838314LOX3LipoxygenaseO.I.H.G.
At1g19640838551JMT (JASMONIC ACID CARBOXYL METHYLTRANSFERASE)Encodes a S-adenosyl-L-methionine:jasmonic acid carboxyl methyltransferase that catalyzes the formation of methyljasmonate from jasmonic acid. Its expression is induced in response to wounding or methyljasmonate treatment.O.I.H.G.
At1g20510838639OPCL1 (OPC-8:0 COA LIGASE1)F:4-coumarate-CoA ligase activity;P:phenylpropanoid metabolic process, jasmonic acid biosynthetic process, response to wounding;C:peroxisome;BOFMPAVO.I.H.G.
At1g55020841944LOX1lipoxygenase, a defense gene conferring resistance Xanthomonas campestrisO.I.H.G.
At1g67560843077lipoxygenase family proteinF:electron carrier activity, oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen, lipoxygenase activity, iron ion binding, metal ion binding;P:growth;C:chloroplast;PMBFOO.I.H.G.
At1g72520843584lipoxygenase, putativeF:electron carrier activity, oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen, lipoxygenase activity, iron ion binding, metal ion binding;P:growth, jasmonic acid biosynthetic process, response to wounding, defense response;C:chloroplast;PMBFOO.I.H.G.
At1g76680844001OPR1Encodes a a member of an alpha/beta barrel fold family of FMN-containing oxidoreductases. One of two closely related 12-oxophytodienoic acid reductases. This enzyme is not expected to participate in jasmonic acid biosynthesis because during in vitro assays, it shows very little activity with the naturally occurring OPDA isomer. Up-regulated by senescence and jasmonic acid. Induced by salicylic acid. Independent of NPR1 for their induction by salicylic acid.O.I.H.G.
At1g76690844002OPR2Encodes one of two closely related 12-oxophytodienoic acid reductases. This enzyme is not expected to participate in jasmonic acid biosynthesis because during in vitro assays, it shows very little activity with the naturally occurring OPDA isomer.O.I.H.G.
At2g06050815160OPR3 (OPDA-REDUCTASE 3)Encodes a 12-oxophytodienoate reductase that is required for jasmonate biosynthesis. Mutants are male sterile and defective in pollen dehiscence.O.I.H.G.
At2g33150817876PKT3 (PEROXISOMAL 3-KETOACYL-COA THIOLASE 3)Encodes an organellar (peroxisome, glyoxysome) 3-ketoacyl-CoA thiolase, involved in fatty acid b-oxidation during germination and subsequent seedling growth. Mutants have defects in glyoxysomal fatty acid beta-oxidation. EC2.3.1.16 thiolase.O.I.H.G.
At2g35690818138ACX5 (ACYL-COA OXIDASE 5)Encodes an acyl-CoA oxidase. Involved in jasmonate biosynthesis. Expressed uniformly in seedlings and throughout development.O.I.H.G.
At3g01420821135DOX1Encodes an alpha-dioxygenase involved in protection against oxidative stress and cell death. Induced in response to Salicylic acid and oxidative stress. Independent of NPR1 in induction by salicylic acid.O.I.H.G.
At3g06860819870MFP2 (MULTIFUNCTIONAL PROTEIN 2)Encodes a multifunctional protein. Involved in peroxisomal fatty acid beta oxidation. Loss-of-function mutant lacks hydroxyacyl-CoA dehydrogenase activity and have reduced levels of long-chain enoyl-CoA hydratase activity. The mutant has fewer but larger peroxisomes.O.I.H.G.
At3g22400821808LOX5F:electron carrier activity, oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen, lipoxygenase activity, iron ion binding, metal ion binding;P:root development;C:chloroplast;PMBFOO.I.H.G.
At3g25760822167AOC1 (ALLENE OXIDE CYCLASE 1)encodes allene oxide cyclase. One of four genes in Arabidopsis that encode this enzyme, which catalyzes an essential step in jasmonic acid biosynthesis. Gene expression is induced during senescence, a process that involves jasmonic acid signalling pathway.O.I.H.G.
At3g25770822168AOC2 (ALLENE OXIDE CYCLASE 2)Encodes allene oxide cyclase. One of four genes in Arabidopsis that encode this enzyme, which catalyzes an essential step in jasmonic acid biosynthesis. Gene expression is induced during senescence, a process that involves jasmonic acid signalling pathway. Note: Nomenclature for Arabidopsis allene oxide cyclase 2 (AOC2, AT3G25770) gene is based on Stenzel et al. 2003 Plant Molecular Biology 51:895-911. AOC2 (AT3G25770) is also referred to as AOC3 in He et al. 2002 Plant Physiology, 128:876-884.O.I.H.G.
At3g25780822169AOC3 (ALLENE OXIDE CYCLASE 3)Encodes allene oxide cyclase, one of the enzymes involved in jasmonic acid biosynthesis. One of four genes in Arabidopsis that encode this enzyme. mRNA expression is upregulated in senescing leaves. Note: Nomenclature for Arabidopsis allene oxide cyclase 3 (AOC3, AT3G25780) gene is based on Stenzel et al. 2003 Plant Molecular Biology 51:895-911. AOC3 (AT3G25780) is also referred to as AOC2 in He et al. 2002 Plant Physiology, 128:876-884.O.I.H.G.
At3g45140823650LOX2 (LIPOXYGENASE 2)Chloroplast lipoxygenase required for wound-induced jasmonic acid accumulation in Arabidopsis.Mutants are resistant to Staphylococcus aureus and accumulate salicylic acid upon infection.O.I.H.G.
At3g51840824347ACX4 (ACYL-COA OXIDASE 4)Encodes a short-chain acyl-CoA oxidase, which catalyzes the first step of peroxisomal fatty acid beta-oxidation during early, post-germinative growth in oilseed species. Null mutants virtually lack short-chain acyl-CoA and are resistant to 2,4-dichlorophenoxybutyric acid, which is converted to the herbicide and auxin analogue 2,4-dichlorophenoxyacetic acid by beta-oxidation. Despite the almost complete loss of short-chain activity, lipid catabolism and seedling growth and establishment was unaltered in the acx4 mutant. However, double mutants in acx3acx4 (acx3 encodes medium chain acyl CoA oxidase) were not viable and arrested during embryogenesis.O.I.H.G.
At4g15440827215HPL1 (HYDROPEROXIDE LYASE 1)Encodes a hydroperoxide lyase. Also a member of the CYP74B cytochrome p450 family. In the ecotype Columbia (Col) the gene contains a 10-nucleotide deletion in its first exon that causes it to code for a truncated protein that results in a non-functional hydroperoxide lyase.O.I.H.G.
At4g16760827381ACX1 (ACYL-COA OXIDASE 1)Encodes a medium to long-chain acyl-CoA oxidase. Catalyzes the first step of fatty acid beta-oxidation. Involved in jasmonate biosynthesis. Gene expression is induced by wounding, drought stress, abscisic acid, and jasmonate.O.I.H.G.
At4g29010829022AIM1 (ABNORMAL INFLORESCENCE MERISTEM)Functions in beta-oxidation of fatty acids, similar to CuMFP with L-3-hydroxyacyl-CoA hydrolyase , L-3-hydroxyacyl-dehydrogenase, D-3-hydroxyacyl-CoA epimerase, and 3, 2-enoyl-CoA isomerase activitiesO.I.H.G.
At5g42650834273AOS (ALLENE OXIDE SYNTHASE)Encodes a member of the cytochrome p450 CYP74 gene family that functions as an allene oxide synthase. This enzyme catalyzes dehydration of the hydroperoxide to an unstable allene oxide in the JA biosynthetic pathway. It shows a dual catalytic activity, the major one being a 13-AOS but also expressing a 9-AOS activity.O.I.H.G.
At5g48880834946PKT2 (PEROXISOMAL 3-KETO-ACYL-COA THIOLASE 2)Encodes a peroxisomal 3-keto-acyl-CoA thiolase 2 precursor. EC2.3.1.16 thiolases. AT5G48880.1 is named PKT1 and AT5G48880.2 is named PKT2.O.I.H.G.
At5g65110836635ACX2 (ACYL-COA OXIDASE 2)Encodes an acyl-CoA oxidase presumably involved in long chain fatty acid biosynthesis.O.I.H.G.

Comparison with co-expressed genes



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