Metabolic pathway to genes

Genes assigned in the pathway

Query pathway ID 00480
Pathway name Glutathione metabolism
Organism Arabidopsis_thaliana
Database KEGG PATHWAY

Click Gene ID to show a list of co-expressed genes.

Gene ID Repr. ID Gene name Functional description O.I. H.G. Other DB
At1g02920839295GSTF7Encodes glutathione transferase belonging to the phi class of GSTs. Naming convention according to Wagner et al. (2002).O.I.H.G.
At1g02940839479GSTF5 (GLUTATHIONE S-TRANSFERASE (CLASS PHI) 5)Encodes glutathione transferase belonging to the phi class of GSTs. Naming convention according to Wagner et al. (2002).O.I.H.G.
At1g02950838240ATGSTF4 (GLUTATHIONE S-TRANSFERASE F4)Encodes glutathione transferase belonging to the phi class of GSTs. Naming convention according to Wagner et al. (2002).O.I.H.G.
At1g07890837304APX1 (ascorbate peroxidase 1)Encodes a cytosolic ascorbate peroxidase APX1. Ascorbate peroxidases are enzymes that scavenge hydrogen peroxide in plant cells. Eight types of APX have been described for Arabidopsis: three cytosolic (APX1, APX2, APX6), two chloroplastic types (stromal sAPX, thylakoid tAPX), and three microsomal (APX3, APX4, APX5) isoforms. At least part of the induction of heat shock proteins during light stress in Arabidopsis is mediated by H2O2 that is scavenged by APX1. Expression of the gene is downregulated in the presence of paraquat, an inducer of photoxidative stress.O.I.H.G.
At1g09420837465G6PD4 (GLUCOSE-6-PHOSPHATE DEHYDROGENASE 4)Encodes a protein similar to glucose-6-phosphate dehydrogenase but, based on amino acid differences in the active site and lack of activity, does not encode a functional G6PDH. The amino acid sequence for the consensus sequence of the G6PDH active site (DHYLGKE) differs in three places in this protein. gc exon splice site at 20574 is based on protein alignment, and is not confirmed experimentally.O.I.H.G.
At1g23820838993SPDS1 (spermidine synthase 1)Spermidine synthase.O.I.H.G.
At1g24280839044G6PD3 (GLUCOSE-6-PHOSPHATE DEHYDROGENASE 3)Encodes a plastidic glucose-6-phosphate dehydrogenase that is sensitive to reduction by DTT and whose mRNA is most highly expressed in root.O.I.H.G.
At1g33660840257peroxidase family proteinPseudogene of AT1G33660; peroxidase family proteinO.I.H.G.
At1g54340841875ICDH (ISOCITRATE DEHYDROGENASE)NADP-specific isocitrate dehydrogenase (ICDH)O.I.H.G.
At1g63460842652glutathione peroxidase, putativeF:glutathione peroxidase activity;P:response to oxidative stress;C:cellular_component unknown;OBMPFVO.I.H.G.
At1g641908427246-phosphogluconate dehydrogenase family proteinF:in 6 functions;P:response to salt stress;C:chloroplast, membrane;BOMPFAVO.I.H.G.
At1g65820842893microsomal glutathione s-transferase, putativeF:glutathione transferase activity;P:biological_process unknown;C:endoplasmic reticulum, vacuole, membrane;MFPOBO.I.H.G.
At1g65930842905isocitrate dehydrogenase, putative / NADP+ isocitrate dehydrogenase, putativeF:isocitrate dehydrogenase (NADP+) activity, copper ion binding;P:response to cadmium ion, response to salt stress, metabolic process;C:apoplast, plasma membrane;OBMPFAO.I.H.G.
At1g70310843367SPDS2 (spermidine synthase 2)Spermidine synthase.O.I.H.G.
At1g77490844085TAPX (THYLAKOIDAL ASCORBATE PEROXIDASE)Encodes a chloroplastic thylakoid ascorbate peroxidase tAPX. Ascorbate peroxidases are enzymes that scavenge hydrogen peroxide in plant cells. Eight types of APX have been described for Arabidopsis: three cytosolic (APX1, APX2, APX6), two chloroplastic types (stromal sAPX, thylakoid tAPX), and three microsomal (APX3, APX4, APX5) isoforms.O.I.H.G.
At2g02930814822ATGSTF3 (GLUTATHIONE S-TRANSFERASE F3)Encodes glutathione transferase belonging to the phi class of GSTs. Naming convention according to Wagner et al. (2002).O.I.H.G.
At2g21790816715RNR1 (RIBONUCLEOTIDE REDUCTASE 1)encodes large subunit of ribonucleotide reductase involved in the production of deoxyribonucleoside triphosphates (dNTPs) for DNA replication and repairO.I.H.G.
At2g24200816954cytosol aminopeptidaseF:manganese ion binding, metalloexopeptidase activity, aminopeptidase activity;P:response to cadmium ion, proteolysis;C:vacuole;OBMPFAO.I.H.G.
At2g25080817046ATGPX1 (GLUTATHIONE PEROXIDASE 1)Encodes glutathione peroxidase.O.I.H.G.
At2g29440817493ATGSTU6 (ARABIDOPSIS THALIANA GLUTATHIONE S-TRANSFERASE TAU 6)Encodes glutathione transferase belonging to the tau class of GSTs. Naming convention according to Wagner et al. (2002).O.I.H.G.
At2g29460817495ATGSTU4 (ARABIDOPSIS THALIANA GLUTATHIONE S-TRANSFERASE TAU 4)Encodes glutathione transferase belonging to the tau class of GSTs. Naming convention according to Wagner et al. (2002).O.I.H.G.
At2g29480817497ATGSTU2 (ARABIDOPSIS THALIANA GLUTATHIONE S-TRANSFERASE TAU 2)Encodes glutathione transferase belonging to the tau class of GSTs. Naming convention according to Wagner et al. (2002).O.I.H.G.
At2g29490817498ATGSTU1 (GLUTATHIONE S-TRANSFERASE TAU 1)Encodes glutathione transferase belonging to the tau class of GSTs. Naming convention according to Wagner et al. (2002).O.I.H.G.
At2g30860817636ATGSTF9 (GLUTATHIONE S-TRANSFERASE PHI 9)Encodes glutathione transferase belonging to the phi class of GSTs. Naming convention according to Wagner et al. (2002).O.I.H.G.
At2g31570817715ATGPX2 (GLUTATHIONE PEROXIDASE 2)glutathione peroxidase GPxO.I.H.G.
At2g47730819386ATGSTF8 (ARABIDOPSIS THALIANA GLUTATHIONE S-TRANSFERASE PHI 8)Encodes glutathione transferase belonging to the phi class of GSTs. Naming convention according to Wagner et al. (2002).O.I.H.G.
At2g48150819427ATGPX4 (GLUTATHIONE PEROXIDASE 4)Encodes glutathione peroxidase.O.I.H.G.
At3g023608211636-phosphogluconate dehydrogenase family proteinF:in 6 functions;P:response to salt stress;C:peroxisome;BOMPFAVO.I.H.G.
At3g03190821227ATGSTF11 (GLUTATHIONE S-TRANSFERASE F11)Encodes glutathione transferase belonging to the phi class of GSTs. Naming convention according to Wagner et al. (2002).O.I.H.G.
At3g09640820121APX2 (ASCORBATE PEROXIDASE 2)Encodes a cytosolic ascorbate peroxidase APX2. Ascorbate peroxidases are enzymes that scavenge hydrogen peroxide in plant cells. Eight types of APX have been described for Arabidopsis: three cytosolic (APX1, APX2, APX6), two chloroplastic types (stromal sAPX, thylakoid tAPX), and three microsomal (APX3, APX4, APX5) isoforms.O.I.H.G.
At3g27060822324TSO2 (TSO meaning 'ugly' in Chinese)Encodes one of the 3 ribonucleotide reductase (RNR) small subunit genes. TSO2 transcription occurs predominantly at the S-phase of the cell cycle and its expression pattern is consistent with its role in dNDP biosynthesis during DNA replication in actively dividing cells. Critical for cell cycle progression, DNA damage repair and plant development.O.I.H.G.
At3g27300822349G6PD5 (glucose-6-phosphate dehydrogenase 5)F:glucose-6-phosphate dehydrogenase activity;P:response to cadmium ion, pentose-phosphate shunt, oxidative branch, glucose metabolic process;C:cytosol, chloroplast;BOMPFVO.I.H.G.
At3g43800823491ATGSTU27 (GLUTATHIONE S-TRANSFERASE TAU 27)Encodes glutathione transferase belonging to the tau class of GSTs. Naming convention according to Wagner et al. (2002).O.I.H.G.
At3g54660824631GR (GLUTATHIONE REDUCTASE)Encodes glutathione reductase that is most likely localized in the chloroplast.O.I.H.G.
At3g63080825483ATGPX5 (glutathione peroxidase 5)Encodes glutathione peroxidase.O.I.H.G.
At4g08390826396SAPX (STROMAL ASCORBATE PEROXIDASE)Encodes a chloroplastic stromal ascorbate peroxidase sAPX. Ascorbate peroxidases are enzymes that scavenge hydrogen peroxide in plant cells. Eight types of APX have been described for Arabidopsis: three cytosolic (APX1, APX2, APX6), two chloroplastic types (stromal sAPX, thylakoid tAPX), and three microsomal (APX3, APX4, APX5) isoforms.O.I.H.G.
At4g09010826480APX4 (ASCORBATE PEROXIDASE 4)Encodes a microsomal ascorbate peroxidase APX4. Ascorbate peroxidases are enzymes that scavenge hydrogen peroxide in plant cells. Eight types of APX have been described for Arabidopsis: three cytosolic (APX1, APX2, APX6), two chloroplastic types (stromal sAPX, thylakoid tAPX), and three microsomal (APX3, APX4, APX5) isoforms.O.I.H.G.
At4g11600826765ATGPX6 (GLUTATHIONE PEROXIDASE 6)Encodes glutathione peroxidase.O.I.H.G.
At4g30910829215cytosol aminopeptidase family proteinF:manganese ion binding, metalloexopeptidase activity, aminopeptidase activity;P:proteolysis, protein metabolic process;C:chloroplast;OBMPFAO.I.H.G.
At4g30920829216cytosol aminopeptidase family proteinF:manganese ion binding, metalloexopeptidase activity, aminopeptidase activity;P:proteolysis, protein metabolic process;C:chloroplast, vacuole;OBMPFAO.I.H.G.
At4g31870829316ATGPX7 (glutathione peroxidase 7)Encodes glutathione peroxidase.O.I.H.G.
At4g32320829366APX6Encodes a cytosolic ascorbate peroxidase APX6. Ascorbate peroxidases are enzymes that scavenge hydrogen peroxide in plant cells. Eight types of APX have been described for Arabidopsis: three cytosolic (APX1, APX2, APX6), two chloroplastic types (stromal sAPX, thylakoid tAPX), and three microsomal (APX3, APX4, APX5) isoforms.O.I.H.G.
At4g35000829652APX3 (ASCORBATE PEROXIDASE 3)Encodes a microsomal ascorbate peroxidase APX3. Ascorbate peroxidases are enzymes that scavenge hydrogen peroxide in plant cells. Eight types of APX have been described for Arabidopsis: three cytosolic (APX1, APX2, APX6), two chloroplastic types (stromal sAPX, thylakoid tAPX), and three microsomal (APX3, APX4, APX5) isoforms. The APX3 protein interacts with AKR2 (ankyrin-containing protein that interacts with AFT1) and AFT1, a 14-3-3 protein.O.I.H.G.
At4g35970829751APX5 (ASCORBATE PEROXIDASE 5)Encodes a microsomal ascorbate peroxidase APX5. Ascorbate peroxidases are enzymes that scavenge hydrogen peroxide in plant cells. Eight types of APX have been described for Arabidopsis: three cytosolic (APX1, APX2, APX6), two chloroplastic types (stromal sAPX, thylakoid tAPX), and three microsomal (APX3, APX4, APX5) isoforms.O.I.H.G.
At4g39640830118GGT1 (GAMMA-GLUTAMYL TRANSPEPTIDASE 1)The gene encodes a gamma-glutamyltransferase (AKA gamma-glutamyl transpeptidase, EC 2.3.2.2) that is located in vascular tissues (predominantly phloem) of leaves and is involved in the degradation of glutathione. The encoded enzyme also mitigates oxidative stress by metabolizing GSSG (oxidized form of GSH - glutathione) in the apoplast.O.I.H.G.
At5g13110831150G6PD2 (GLUCOSE-6-PHOSPHATE DEHYDROGENASE 2)Encodes a plastidic glucose-6-phosphate dehydrogenase that is sensitive to reduction by DTT and whose mRNA is most highly expressed in root.O.I.H.G.
At5g14590831311isocitrate dehydrogenase, putative / NADP+ isocitrate dehydrogenase, putativeF:isocitrate dehydrogenase (NADP+) activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;P:isocitrate metabolic process, metabolic process;C:mitochondrion, chloroplast;OBMPFAO.I.H.G.
At5g27380832797GSH2 (GLUTATHIONE SYNTHETASE 2)Encodes a protein with similarity to glutathione synthetases, which catalyzes one of the early steps in glutathione biosynthesis. Two transcripts have been detected; the longer transcript is less abundant and the protein is localized to the chloroplast. The smaller transcript, in which the transit peptide is truncated, is localized to the cytosol.O.I.H.G.
At5g35790833559G6PD1 (GLUCOSE-6-PHOSPHATE DEHYDROGENASE 1)Encodes a plastidic glucose-6-phosphate dehydrogenase that is sensitive to reduction by DTT and whose mRNA is more prevalent in developing organs but absent in the root.O.I.H.G.
At5g37830833761OXP1 (OXOPROLINASE 1)Encodes a 5-oxoprolinase that acts in the glutathione degradation pathway and in 5-oxoproline metabolism.O.I.H.G.
At5g40760834076G6PD6 (GLUCOSE-6-PHOSPHATE DEHYDROGENASE 6)Encodes a cytosolic glucose-6-phosphate dehydrogenase that is insensitive to reduction by DTT and whose mRNA is expressed ubiquitously.O.I.H.G.
At5g416708341696-phosphogluconate dehydrogenase family proteinF:in 6 functions;P:response to fructose stimulus, response to cadmium ion, response to sucrose stimulus, response to glucose stimulus;C:mitochondrion, chloroplast;BOMPFAVO.I.H.G.
At5g53120835392SPDS3 (SPERMIDINE SYNTHASE 3)encodes a novel spermine synthase and is a paralog of previously characterized spermidine synthases, SPDS1 and SPDS2. SPDS3 forms heterodimers with SDPS2, which in turn forms heterodimers with SDPS1 in vivo. The gene does not complement speDelta3 deficiency of spermidine synthase in yeast but DOES complement speDelta4 deficiency.O.I.H.G.

Comparison with co-expressed genes



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