Metabolic pathway to genes

Genes assigned in the pathway

Query pathway ID 00330
Pathway name Arginine and proline metabolism
Organism Arabidopsis_thaliana
Database KEGG PATHWAY

Click Gene ID to show a list of co-expressed genes.

Gene ID Repr. ID Gene name Functional description O.I. H.G. Other DB
At1g23800838991ALDH2B7Encodes a mitochondrial aldehyde dehydrogenase; nuclear gene for mitochondrial product.O.I.H.G.
At1g23820838993SPDS1 (spermidine synthase 1)Spermidine synthase.O.I.H.G.
At1g44180841021aminoacylase, putative / N-acyl-L-amino-acid amidohydrolase, putativeF:metallopeptidase activity, aminoacylase activity;P:amino acid metabolic process, proteolysis;C:endomembrane system, cytoplasm;BOMFAPVO.I.H.G.
At1g44820841046aminoacylase, putative / N-acyl-L-amino-acid amidohydrolase, putativeF:metallopeptidase activity, aminoacylase activity;P:amino acid metabolic process, proteolysis;C:endomembrane system, cytoplasm;BOMFAPVO.I.H.G.
At1g48470841268GLN1Encodes cytosolic glutamine synthase isozyme. Expression of mRNA is not detectable in roots.O.I.H.G.
At1g51720841597glutamate dehydrogenase, putativeF:oxidoreductase activity, binding, catalytic activity;P:amino acid metabolic process, metabolic process;C:cellular_component unknown;BOMPAFO.I.H.G.
At1g54100841849ALDH7B4 (Aldehyde Dehydrogenase 7B4)Aldehyde dehydrogenaseO.I.H.G.
At1g62800842579ASP4 (ASPARTATE AMINOTRANSFERASE 4)Encodes aspartate aminotransferase (Asp4).O.I.H.G.
At1g67550843076URE (UREASE)Encodes a nickel-containing urea hydrolase involved in nitrogen recycling. It requires three urease accessory proteins for its activation.O.I.H.G.
At1g70310843367SPDS2 (spermidine synthase 2)Spermidine synthase.O.I.H.G.
At1g75330843869OTC (ORNITHINE CARBAMOYLTRANSFERASE)F:amino acid binding, ornithine carbamoyltransferase activity, carboxyl- or carbamoyltransferase activity;P:amino acid metabolic process;C:chloroplast, chloroplast stroma;BOAFMPVO.I.H.G.
At1g80600844399WIN1 (HOPW1-1-INTERACTING 1)Encodes HopW1-1-Interacting protein 1 (WIN1). Interacts with the P. syringae effector HopW1-1. WIN1 is a putative acetylornithine transaminase. Modulates plant defenses against bacteria. Three WIN proteins are identified so far (WIN1: AT1G80600; WIN2: AT4G31750; WIN3: AT5G13320).O.I.H.G.
At2g14260815913PIPencodes proline iminopeptidaseO.I.H.G.
At2g16500816149ADC1 (ARGININE DECARBOXYLASE 1)encodes a arginine decarboxylase (ADC), a rate-limiting enzyme that catalyzes the first step of polyamine (PA) biosynthesis via ADC pathway in Arabidopsis thaliana. Arabidopsis genome has two ADC paralogs, ADC1 and ADC2. Double mutant analysis showed that ADC genes are essential for the production of PA, and are required for normal seed development. Promoter region of ADC1 contains 742-bp AT-rich transposable element, called AtATE, that belongs to the MITE families of repetitive elements.O.I.H.G.
At2g19940816513N-acetyl-gamma-glutamyl-phosphate reductase/ NAD or NADH binding / binding / catalytic/ oxidoreductase, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor / protein dimerizationF:in 6 functions;P:amino acid metabolic process, response to cadmium ion;C:nucleolus, chloroplast stroma, chloroplast, membrane;BOAFPO.I.H.G.
At2g22910816822GCN5-related N-acetyltransferase (GNAT) family protein / amino acid kinase family proteinF:amino-acid N-acetyltransferase activity, N-acetyltransferase activity;P:arginine biosynthetic process, amino acid biosynthetic process, metabolic process;C:cytoplasm;BOAFPO.I.H.G.
At2g24200816954cytosol aminopeptidaseF:manganese ion binding, metalloexopeptidase activity, aminopeptidase activity;P:response to cadmium ion, proteolysis;C:vacuole;OBMPFAO.I.H.G.
At2g30970817648ASP1 (ASPARTATE AMINOTRANSFERASE 1)ASPARTATE AMINOTRANSFERASE 1O.I.H.G.
At2g37500818326arginine biosynthesis protein ArgJ familyF:glutamate N-acetyltransferase activity;P:arginine biosynthetic process;C:chloroplast;OBFAPO.I.H.G.
At2g39800818566P5CS1 (DELTA1-PYRROLINE-5-CARBOXYLATE SYNTHASE 1)encodes a delta1-pyrroline-5-carboxylate synthase that catalyzes the rate-limiting enzyme in the biosynthesis of proline. Gene is expressed in reproductive organs and tissues under non-stress conditions but in the whole plant under water-limiting condition. Expression is also induced by abscisic acid and salt stress in a light-dependent manner. P5CS1 appears to be involved in salt stress responses related to proline accumulation, including protection from reactive oxidative species. P5CS1 appears to be present in different cells and/or different subcellular locations from P5CS2 in a tissue-dependent manner.O.I.H.G.
At3g02470821214SAMDC (S-ADENOSYLMETHIONINE DECARBOXYLASE)Encodes a S-adenosylmethionine decarboxylase involved in polyamine biosynthesis.O.I.H.G.
At3g03910821072GDH3 (GLUTAMATE DEHYDROGENASE 3)GDH3 encodes a member of the glutamate dehydrogenease family. Its expression is upregulated in response to cytokinin and it may play a role in the control of nitrogen metabolism in leaf development.O.I.H.G.
At3g17820821050ATGSKB6encodes a cytosolic glutamine synthetase, the enzyme has low affinity with substrate ammoniumO.I.H.G.
At3g25570822144adenosylmethionine decarboxylase family proteinF:adenosylmethionine decarboxylase activity;P:spermidine biosynthetic process, spermine biosynthetic process;C:cellular_component unknown;PMFOBO.I.H.G.
At3g28480822478oxidoreductase, 2OG-Fe(II) oxygenase family proteinF:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors, oxidoreductase activity, iron ion binding;P:protein metabolic process, peptidyl-proline hydroxylation to 4-hydroxy-L-proline;C:Golgi apparatus, plasma membrane;MOPBFVO.I.H.G.
At3g48000823955ALDH2B4 (ALDEHYDE DEHYDROGENASE 2B4)Encodes a putative (NAD+) aldehyde dehydrogenase.O.I.H.G.
At3g55610824727P5CS2 (DELTA 1-PYRROLINE-5-CARBOXYLATE SYNTHASE 2)encodes delta 1-pyrroline-5-carboxylate synthetase B. Gene expression is induced by dehydration, high salt and ABA. Knock-out mutations in P5CS2 are embryo-lethal. P5CS2 appears to be present in different cells and/or different subcellular locations from P5CS1 in a tissue-dependent manner.O.I.H.G.
At3g57560824923aspartate/glutamate/uridylate kinase family proteinencodes a N-acetylglutamate kinase, involved in arginine biosynthesisO.I.H.G.
At4g08900826468arginaseEncodes an arginase, likely to be involved in polyamine biosynthesis in pollen.O.I.H.G.
At4g17830827506peptidase M20/M25/M40 family proteinF:metallopeptidase activity, hydrolase activity, protein dimerization activity;P:proteolysis;C:unknown;BOMAFPO.I.H.G.
At4g24830828586arginosuccinate synthase familyF:argininosuccinate synthase activity, ATP binding;P:arginine biosynthetic process;C:chloroplast stroma, chloroplast;OBMAFPO.I.H.G.
At4g30910829215cytosol aminopeptidase family proteinF:manganese ion binding, metalloexopeptidase activity, aminopeptidase activity;P:proteolysis, protein metabolic process;C:chloroplast;OBMPFAO.I.H.G.
At4g31990829330ASP5 (ASPARTATE AMINOTRANSFERASE 5)encodes a plastid-localized aspartate aminotransferaseO.I.H.G.
At4g34240829573ALDH3I1 (ALDEHYDE DEHYDROGENASE 3|1)Aldehyde dehydrogenase induced by ABA and dehydrationO.I.H.G.
At4g34710829623ADC2 (ARGININE DECARBOXYLASE 2)encodes a arginine decarboxylase (ADC), a rate-limiting enzyme that catalyzes the first step of polyamine (PA) biosynthesis via ADC pathway in Arabidopsis thaliana. Arabidopsis genome has two ADC paralogs, ADC1 and ADC2. ADC2 is stress-inducible (osmotic stress). Double mutant analysis showed that ADC genes are essential for the production of PA, and are required for normal seed development. Overexpression causes phenotypes similar to GA-deficient plants and these plants show reduced levels of GA due to lower expression levels of AtGA20ox1, AtGA3ox3 and AtGA3ox1.O.I.H.G.
At5g07440830635GDH2 (GLUTAMATE DEHYDROGENASE 2)Encodes the beta-subunit of the glutamate dehydrogenase. The enzyme is almost exclusively found in the mitochondria of stem and leaf companion cells.O.I.H.G.
At5g08170830713EMB1873 (EMBRYO DEFECTIVE 1873)F:agmatine deiminase activity;P:embryonic development ending in seed dormancy, polyamine biosynthetic process;C:cellular_component unknown;BOPFAVMO.I.H.G.
At5g10920830959argininosuccinate lyase, putative / arginosuccinase, putativeF:argininosuccinate lyase activity, catalytic activity;P:arginine biosynthetic process via ornithine, arginine biosynthetic process;C:chloroplast, chloroplast stroma;BOAMFPO.I.H.G.
At5g11520831024ASP3 (ASPARTATE AMINOTRANSFERASE 3)Encodes the chloroplastic isozyme of aspartate aminotransferase. Involved in aspartate biosynthesis and nitrogen metabolism. mRNA is expressed in senescing leaves.O.I.H.G.
At5g14800831332P5CR (PYRROLINE-5- CARBOXYLATE (P5C) REDUCTASE)Delta 1-pyrroline-5-carboxylate reductase, catalyzes the final step in proline biosynthesis from glutamate and ornithine.In situ hybridization indicated that under normal growth conditions, the highest concentration of P5CR transcripts occurs in the cortical parenchyma, phloem, vascular cambium and pith parenchyma in the vicinity of the protoxylem. Single gene in Arabidopsis.O.I.H.G.
At5g15950831452adenosylmethionine decarboxylase family proteinF:adenosylmethionine decarboxylase activity;P:spermidine biosynthetic process, spermine biosynthetic process, polyamine biosynthetic process;C:cellular_component unknown;PMFOBO.I.H.G.
At5g16570831519GLN1Encodes a cytosolic glutamine synthetase, the enzyme has high affinity with substrate ammoniumO.I.H.G.
At5g18170831935GDH1 (GLUTAMATE DEHYDROGENASE 1)Encodes the 43 kDa alpha-subunit of the glutamate dehydrogenase with a putative mitochondrial transit polypeptide and NAD(H)- and alpha-ketoglutarate-binding domains. Mitochondrial localization confirmed by subcellular fractionation. Combines in several ratios with GDH2 protein (GDH-beta) to form seven isoenzymes. Catalyzes the cleavage of glycine residues. May be involved in ammonia assimilation under conditions of inorganic nitrogen excess. The enzyme is almost exclusively found in the mitochondria of stem and leaf companion cells.O.I.H.G.
At5g18930832011BUD2 (BUSHY AND DWARF 2)F:adenosylmethionine decarboxylase activity;P:spermidine biosynthetic process, spermine biosynthetic process, polyamine biosynthetic process;C:cellular_component unknown;PMFOBO.I.H.G.
At5g19550832075ASP2 (ASPARTATE AMINOTRANSFERASE 2)Nitrogen metabolism. Major cytosolic isoenzyme controlling aspartate biosynthesis in the light.O.I.H.G.
At5g35630833535GS2 (GLUTAMINE SYNTHETASE 2)chloroplastic glutamine synthetaseO.I.H.G.
At5g37600833738ATGSR1encodes a cytosolic glutamine synthetase, the enzyme has high affinity with substrate ammoniumO.I.H.G.
At5g46180834660delta-OATornithine delta-aminotransferaseO.I.H.G.
At5g53120835392SPDS3 (SPERMIDINE SYNTHASE 3)encodes a novel spermine synthase and is a paralog of previously characterized spermidine synthases, SPDS1 and SPDS2. SPDS3 forms heterodimers with SDPS2, which in turn forms heterodimers with SDPS1 in vivo. The gene does not complement speDelta3 deficiency of spermidine synthase in yeast but DOES complement speDelta4 deficiency.O.I.H.G.
At5g62530836373ALDH12A1Encodes mitochondrial Delta-pyrroline-5- carboxylate dehydrogenase. Involved in the catabolism of proline to glutamate. Involved in protection from proline toxicity. Induced at pathogen infection sites. P5CDH and SRO5 (an overlapping gene in the sense orientation) generate 24-nt and 21-nt siRNAs, which together are components of a regulatory loop controlling reactive oxygen species (ROS) production and stress response.O.I.H.G.

Comparison with co-expressed genes



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