Metabolic pathway to genes

Genes assigned in the pathway

Query pathway ID 00290
Pathway name Valine, leucine and isoleucine biosynthesis
Organism Arabidopsis_thaliana
Database KEGG PATHWAY

Click Gene ID to show a list of co-expressed genes.

Gene ID Repr. ID Gene name Functional description O.I. H.G. Other DB
At1g01090839429PDH-E1 ALPHA (PYRUVATE DEHYDROGENASE E1 ALPHA)pyruvate dehydrogenase E1 alpha subunitO.I.H.G.
At1g09620837489ATP binding / aminoacyl-tRNA ligase/ leucine-tRNA ligase/ nucleotide bindingF:nucleotide binding, aminoacyl-tRNA ligase activity, leucine-tRNA ligase activity, ATP binding;P:leucyl-tRNA aminoacylation, translation, tRNA aminoacylation for protein translation;C:chloroplast;BOMAFPO.I.H.G.
At1g10070837543ATBCAT-2 (ARABIDOPSIS THALIANA BRANCHED-CHAIN AMINO ACID TRANSAMINASE 2)Encodes a chloroplast branched-chain amino acid aminotransferase. Complements the yeast leu/iso-leu/val auxotrophy mutant.O.I.H.G.
At1g14610838023TWN2 (TWIN 2)Required for proper proliferation of basal cells.O.I.H.G.
At1g18500838431MAML-4 (METHYLTHIOALKYLMALATE SYNTHASE-LIKE 4)Encodes an active Arabidopsis isopropylmalate synthase IPMS1. Involved in leucine biosynthesis. Do not participate in the chain elongation of glucosinolates. Expressed constitutively throughout the plant. Loss of IPMS1 can be compensated by a second isopropylmalate synthase gene IPMS2 (At1g74040).O.I.H.G.
At1g24180839031IAR4Arabidopsis thaliana pyruvate dehydrogenase E1a-like subunit. 81% identical to a previously characterized Arabidopsis mitochondrial PDH E1a-subunit, At1g59900O.I.H.G.
At1g30120839891PDH-E1 BETA (PYRUVATE DEHYDROGENASE E1 BETA)Encodes a putative plastid pyruvate dehydrogenase E1 beta subunit that is distinct from the mitochondrial pyruvate dehydrogenase E1 beta subunit.O.I.H.G.
At1g311808400063-isopropylmalate dehydrogenase, chloroplast, putativeThe AtIMD3 is one out of 3 genes encoding the enzyme 3-isopropylmalate dehydrogenase involved in leucine biosynthesis in Arabidopsis. Its subcellular location has been targeted to plastids.O.I.H.G.
At1g50090841432aminotransferase class IV family proteinF:branched-chain-amino-acid transaminase activity, catalytic activity;P:branched chain family amino acid metabolic process, metabolic process;C:cellular_component unknown;BOFMPAO.I.H.G.
At1g50110841433branched-chain amino acid aminotransferase 6 / branched-chain amino acid transaminase 6 (BCAT6)F:branched-chain-amino-acid transaminase activity, catalytic activity;P:branched chain family amino acid metabolic process, metabolic process;C:cellular_component unknown;BOFMPAO.I.H.G.
At1g59900842284AT-E1 ALPHAencodes the e1 alpha subunit of the pyruvate dehydrogenase complex (PDC)O.I.H.G.
At1g74040843742IMS1 (2-ISOPROPYLMALATE SYNTHASE 1)Encodes an active Arabidopsis isopropylmalate synthase IPMS2. Involved in leucine biosynthesis. Do not participate in the chain elongation of glucosinolates. Expressed constitutively throughout the plant. Loss of IPMS2 can be compensated by a second isopropylmalate synthase gene IPMS1 (At1g18500).O.I.H.G.
At1g805608443953-isopropylmalate dehydrogenase, chloroplast, putativeThe AtIMD2 is one out of 3 genes encoding the enzyme 3-isopropylmalate dehydrogenase involved in leucine biosynthesis in Arabidopsis. Its subcellular location has been targeted to plastids.O.I.H.G.
At2g34590818024transketolase family proteinF:pyruvate dehydrogenase (acetyl-transferring) activity, transketolase activity;P:pollen tube development;C:chloroplast, chloroplast envelope;BOMPFAO.I.H.G.
At2g43090818911aconitase C-terminal domain-containing proteinF:hydro-lyase activity, 3-isopropylmalate dehydratase activity;P:response to salt stress, metabolic process;C:chloroplast, chloroplast stroma;BOFAPMO.I.H.G.
At3g10050820166OMR1 (L-O-METHYLTHREONINE RESISTANT 1)first enzyme in the biosynthetic pathway of isoleucineO.I.H.G.
At3g19710821508BCAT4 (BRANCHED-CHAIN AMINOTRANSFERASE4)Belongs to the branched-chain amino acid aminotransferase gene family. Encodes a methionine-oxo-acid transaminase. Involved in the methionine chain elongation pathway that leads to the ultimate biosynthesis of methionine-derived glucosinolates.O.I.H.G.
At3g23940821977dehydratase familyF:catalytic activity, dihydroxy-acid dehydratase activity;P:branched chain family amino acid biosynthetic process, isoleucine biosynthetic process, metabolic process, valine biosynthetic process;C:chloroplast stroma, chloroplast;OBFAPMO.I.H.G.
At3g48560824015CSR1 (CHLORSULFURON/IMIDAZOLINONE RESISTANT 1)Catalyzes the formation of acetolactate from pyruvate, the first step in valine and isoleucine biosynthesis. Requires FAD, thiamine pyrophosphate and Mg. Inhibited by the sulphonylurea herbicide, chlorsulphuron, and the imidazolinone herbicide, imazapyr. The obtained crystal structure of acetohydroxyacid synthase AHAS, EC 2.2.1.6)in complex with herbicides of the sulphonylurea and imidazolinone family reveals the molecular basis for substrate/inhibitor binding.O.I.H.G.
At3g49680824130BCAT3 (BRANCHED-CHAIN AMINOTRANSFERASE 3)Encodes a chloroplast branched-chain amino acid aminotransferase. Complements the yeast leu/iso-leu/val auxotrophy mutant.O.I.H.G.
At3g58610825030ketol-acid reductoisomeraseF:coenzyme binding, oxidoreductase activity, binding, ketol-acid reductoisomerase activity, catalytic activity;P:response to cadmium ion, branched chain family amino acid biosynthetic process;C:in 6 components;BOFAPO.I.H.G.
At4g04350825755EMB2369 (EMBRYO DEFECTIVE 2369)F:aminoacyl-tRNA ligase activity, nucleotide binding, leucine-tRNA ligase activity, ATP binding;P:embryonic development ending in seed dormancy, tRNA aminoacylation for protein translation;C:mitochondrion, chloroplast;OBAMFPVO.I.H.G.
At4g10320826624isoleucyl-tRNA synthetase, putative / isoleucine--tRNA ligase, putativeF:isoleucine-tRNA ligase activity, nucleotide binding, aminoacyl-tRNA ligase activity, ATP binding;P:response to cadmium ion, tRNA aminoacylation for protein translation;C:cytosol;OBAMFPO.I.H.G.
At4g13430826975IIL1 (ISOPROPYL MALATE ISOMERASE LARGE SUBUNIT 1)F:4 iron, 4 sulfur cluster binding, lyase activity, hydro-lyase activity;P:response to cadmium ion, metabolic process;C:chloroplast stroma, chloroplast;OBFMAPO.I.H.G.
At5g16715831533EMB2247 (embryo defective 2247)F:valine-tRNA ligase activity, nucleotide binding, aminoacyl-tRNA ligase activity, ATP binding;P:embryonic development ending in seed dormancy, tRNA aminoacylation for protein translation;C:chloroplast stroma, chloroplast;OBMAFPO.I.H.G.
At5g23010832365MAM1 (METHYLTHIOALKYLMALATE SYNTHASE 1)Encodes a methylthioalkylmalate synthase, catalyzes the condensation reactions of the first two rounds of methionine chain elongation in the biosynthesis of methionine-derived glucosinolates.O.I.H.G.
At5g23020832366IMS2 (2-ISOPROPYLMALATE SYNTHASE 2)methylthioalkymalate synthase-like. Also known as 2-isopropylmalate synthase (IMS2). encodes a methylthioalkylmalate synthase involved in the biosynthesis of aliphatic glucosinolates which accepts all the omega-methylthio-2-oxoalkanoic acids needed to form the known C3 to C8 glucosinolates in Arabidopsis.O.I.H.G.
At5g49030834962OVA2 (ovule abortion 2)F:nucleotide binding, isoleucine-tRNA ligase activity, aminoacyl-tRNA ligase activity, catalytic activity, ATP binding;P:ovule development, tRNA aminoacylation for protein translation;C:chloroplast;OBMAFPO.I.H.G.
At5g50850835157MAB1 (MACCI-BOU)F:pyruvate dehydrogenase (acetyl-transferring) activity, catalytic activity;P:defense response to bacterium;C:mitochondrion, nucleolus, plasma membrane;BOMPFAO.I.H.G.
At5g57850835895aminotransferase class IV family proteinF:4-amino-4-deoxychorismate lyase activity, catalytic activity;P:tetrahydrofolate biosynthetic process;C:chloroplast;BOAPFO.I.H.G.
At5g65780836707ATBCAT-5encodes a chloroplast branched-chain amino acid aminotransferase, can complement the yeast leu/iso-leu/val auxotrophy mutantO.I.H.G.

Comparison with co-expressed genes



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