Metabolic pathway to genes

Genes assigned in the pathway

Query pathway ID 00280
Pathway name Valine, leucine and isoleucine degradation
Organism Arabidopsis_thaliana
Database KEGG PATHWAY

Click Gene ID to show a list of co-expressed genes.

Gene ID Repr. ID Gene name Functional description O.I. H.G. Other DB
At1g04710839434PKT4 (PEROXISOMAL 3-KETOACYL-COA THIOLASE 4)EC2.3.1.16 thiolase.O.I.H.G.
At1g10070837543ATBCAT-2 (ARABIDOPSIS THALIANA BRANCHED-CHAIN AMINO ACID TRANSAMINASE 2)Encodes a chloroplast branched-chain amino acid aminotransferase. Complements the yeast leu/iso-leu/val auxotrophy mutant.O.I.H.G.
At1g214008387392-oxoisovalerate dehydrogenase, putative / 3-methyl-2-oxobutanoate dehydrogenase, putative / branched-chain alpha-keto acid dehydrogenase E1 alpha subunit, putativeF:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor, 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity;P:metabolic process;C:unknown;BOMFPAO.I.H.G.
At1g23800838991ALDH2B7Encodes a mitochondrial aldehyde dehydrogenase; nuclear gene for mitochondrial product.O.I.H.G.
At1g48030841221mtLPD1 (mitochondrial lipoamide dehydrogenase 1)Encodes a mitochondrial lipoamide dehydrogenase whose expression is induced by light.O.I.H.G.
At1g50090841432aminotransferase class IV family proteinF:branched-chain-amino-acid transaminase activity, catalytic activity;P:branched chain family amino acid metabolic process, metabolic process;C:cellular_component unknown;BOFMPAO.I.H.G.
At1g50110841433branched-chain amino acid aminotransferase 6 / branched-chain amino acid transaminase 6 (BCAT6)F:branched-chain-amino-acid transaminase activity, catalytic activity;P:branched chain family amino acid metabolic process, metabolic process;C:cellular_component unknown;BOFMPAO.I.H.G.
At1g54100841849ALDH7B4 (Aldehyde Dehydrogenase 7B4)Aldehyde dehydrogenaseO.I.H.G.
At1g55510841998BCDH BETA1 (BRANCHED-CHAIN ALPHA-KETO ACID DECARBOXYLASE E1 BETA SUBUNIT)branched-chain alpha-keto acid decarboxylase E1 betaO.I.H.G.
At2g14170815903ALDH6B2Arabidopsis thaliana methylmalonate-semialdehyde dehydrogenaseO.I.H.G.
At2g26800817221hydroxymethylglutaryl-CoA lyase, putative / 3-hydroxy-3-methylglutarate-CoA lyase, putative / HMG-CoA lyase, putativeF:hydroxymethylglutaryl-CoA lyase activity, catalytic activity;P:leucine metabolic process, metabolic process;C:mitochondrion;BOAFMPO.I.H.G.
At2g33150817876PKT3 (PEROXISOMAL 3-KETOACYL-COA THIOLASE 3)Encodes an organellar (peroxisome, glyoxysome) 3-ketoacyl-CoA thiolase, involved in fatty acid b-oxidation during germination and subsequent seedling growth. Mutants have defects in glyoxysomal fatty acid beta-oxidation. EC2.3.1.16 thiolase.O.I.H.G.
At3g06810819865IBR3 (IBA-RESPONSE 3)Encodes a protein with similarity to acyl-CoA dehydrogenases. Mutations in IBR3 render plants resistant to indole-3-butryic acid, a putative storage form of the biologically active auxin IAA (indole-3-acetic acid). IBR3 is hypothesized to carry out the second step in a β-oxidation-like process of IBA metabolism in Arabidopsis. Though its subcellular location has not been determined, IBR3 has a peroxisomal targeting sequence and two other putative IBA metabolic enzymes (IBR1 and IBR10) can be found in this organelle. No specific enzymatic activity has been documented for IBR3, but double mutant analyses with CHY1 argue against a role for IBR3 in general fatty acid β-oxidation.O.I.H.G.
At3g06850819869BCE2dihydrolipoamide branched chain acyltransferaseO.I.H.G.
At3g13450820547DIN4 (DARK INDUCIBLE 4)branched chain alpha-keto acid dehydrogenase E1 betaO.I.H.G.
At3g16950820951LPD1 (LIPOAMIDE DEHYDROGENASE 1)encodes a plastid lipoamide dehydrogenase, subunit of the pyruvate dehydrogenase complex which provides acetyl-CoA for de novo fatty acid biosynthesis. The gene is highly expressed in developing seeds.O.I.H.G.
At3g17240820984mtLPD2 (LIPOAMIDE DEHYDROGENASE 2)lipoamide dehydrogenase precursorO.I.H.G.
At3g19710821508BCAT4 (BRANCHED-CHAIN AMINOTRANSFERASE4)Belongs to the branched-chain amino acid aminotransferase gene family. Encodes a methionine-oxo-acid transaminase. Involved in the methionine chain elongation pathway that leads to the ultimate biosynthesis of methionine-derived glucosinolates.O.I.H.G.
At3g45300823668IVD (ISOVALERYL-COA-DEHYDROGENASE)Encodes isovaleryl-coenzyme a dehydrogenase.O.I.H.G.
At3g48000823955ALDH2B4 (ALDEHYDE DEHYDROGENASE 2B4)Encodes a putative (NAD+) aldehyde dehydrogenase.O.I.H.G.
At3g49680824130BCAT3 (BRANCHED-CHAIN AMINOTRANSFERASE 3)Encodes a chloroplast branched-chain amino acid aminotransferase. Complements the yeast leu/iso-leu/val auxotrophy mutant.O.I.H.G.
At4g11820826788MVA1Encodes a protein with hydroxymethylglutaryl-CoA synthase activity which was characterized by phenotypical complementation of the S. cerevisiae mutant.O.I.H.G.
At4g16155827307dihydrolipoyl dehydrogenaseF:dihydrolipoyl dehydrogenase activity;P:cell redox homeostasis;C:chloroplast, chloroplast envelope;BOMAPFO.I.H.G.
At4g16210827314ECHIA (ENOYL-COA HYDRATASE/ISOMERASE A)F:catalytic activity;P:metabolic process;C:peroxisome;BOMFPAO.I.H.G.
At4g16800827386enoyl-CoA hydratase, putativeF:enoyl-CoA hydratase activity, catalytic activity;P:fatty acid metabolic process, metabolic process;C:cellular_component unknown;BOMFPAO.I.H.G.
At4g209308278413-hydroxyisobutyrate dehydrogenase, putativeF:in 7 functions;P:pentose-phosphate shunt, valine metabolic process, valine catabolic process, metabolic process;C:unknown;OBMFPAVO.I.H.G.
At4g291208290336-phosphogluconate dehydrogenase NAD-binding domain-containing proteinF:coenzyme binding, oxidoreductase activity, phosphogluconate dehydrogenase (decarboxylating) activity, binding, catalytic activity;P:pentose-phosphate shunt, metabolic process;C:unknown;BOMFPAVO.I.H.G.
At4g34030829549MCCB (3-METHYLCROTONYL-COA CARBOXYLASE)MCC-B is involved in leucine degradation in mitochondria. The active protein is a dimer of MCC-A and MCC-B. MCC-A is biotinylated whereas MCC-B is not.O.I.H.G.
At4g34240829573ALDH3I1 (ALDEHYDE DEHYDROGENASE 3|1)Aldehyde dehydrogenase induced by ABA and dehydrationO.I.H.G.
At5g093008307892-oxoisovalerate dehydrogenase, putative / 3-methyl-2-oxobutanoate dehydrogenase, putative / branched-chain alpha-keto acid dehydrogenase E1 alpha subunit, putativeF:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor, 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity;P:metabolic process;C:mitochondrion;BOMFPAO.I.H.G.
At5g34780833376dehydrogenase E1 component family proteinPutative ketopantoate reductase (KPR). This enzyme is speculated to be the missing enzyme in the biosynthesis of pantothenate.O.I.H.G.
At5g48230834876ACAT2 (ACETOACETYL-COA THIOLASE 2)F:acetyl-CoA C-acetyltransferase activity, catalytic activity;P:embryonic development ending in seed dormancy;C:peroxisome, plasma membrane;BOMFAPO.I.H.G.
At5g48880834946PKT2 (PEROXISOMAL 3-KETO-ACYL-COA THIOLASE 2)Encodes a peroxisomal 3-keto-acyl-CoA thiolase 2 precursor. EC2.3.1.16 thiolases. AT5G48880.1 is named PKT1 and AT5G48880.2 is named PKT2.O.I.H.G.
At5g57850835895aminotransferase class IV family proteinF:4-amino-4-deoxychorismate lyase activity, catalytic activity;P:tetrahydrofolate biosynthetic process;C:chloroplast;BOAPFO.I.H.G.
At5g65780836707ATBCAT-5encodes a chloroplast branched-chain amino acid aminotransferase, can complement the yeast leu/iso-leu/val auxotrophy mutantO.I.H.G.

Comparison with co-expressed genes



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