Metabolic pathway to genes

Genes assigned in the pathway

Query pathway ID 00270
Pathway name Cysteine and methionine metabolism
Organism Arabidopsis_thaliana
Database KEGG PATHWAY

Click Gene ID to show a list of co-expressed genes.

Gene ID Repr. ID Gene name Functional description O.I. H.G. Other DB
At1g05010839345EFE (ETHYLENE-FORMING ENZYME)Encodes 1-aminocyclopropane-1-carboxylate oxidaseO.I.H.G.
At1g120108377531-aminocyclopropane-1-carboxylate oxidase, putative / ACC oxidase, putativeencodes a protein whose sequence is similar to 1-amino-cyclopropane-1-carboxylic acid oxidaseO.I.H.G.
At1g14810838046semialdehyde dehydrogenase family proteinencodes an aspartate semialdehyde dehydrogenase, which produces the branch point intermediate for lysine and threonine/methionine biosynthesisO.I.H.G.
At1g23820838993SPDS1 (spermidine synthase 1)Spermidine synthase.O.I.H.G.
At1g31230840011AK-HSDH I (ASPARTATE KINASE-HOMOSERINE DEHYDROGENASE I)Encodes a bifunctional aspartate kinase/homoserine dehydrogenase. These two activities catalyze the first and the third steps toward the synthesis of the essential amino acids threonine, isoleucine and methionine.O.I.H.G.
At1g55880842038pyridoxal-5'-phosphate-dependent enzyme, beta family proteinF:lyase activity, pyridoxal phosphate binding, catalytic activity;P:amino acid metabolic process, cysteine biosynthetic process from serine, metabolic process;C:unknown;BOFMPAO.I.H.G.
At1g55920842043ATSERAT2Encodes a chloroplast/cytosol localized serine O-acetyltransferase involved in sulfur assimilation and cysteine biosynthesis. Expressed in the vascular system.O.I.H.G.
At1g62380842536ACO2 (ACC OXIDASE 2)Encodes a protein similar to 1-aminocyclopropane-1-carboxylic oxidase (ACC oxidase). Expression of the AtACO2 transcripts is affected by ethylene.O.I.H.G.
At1g62800842579ASP4 (ASPARTATE AMINOTRANSFERASE 4)Encodes aspartate aminotransferase (Asp4).O.I.H.G.
At1g64660842774ATMGL (ARABIDOPSIS THALIANA METHIONINE GAMMA-LYASE)Encodes a functional methionine gamma-lyase, a cytosolic enzyme catalyzes the degradation of methionine into methanethiol, alpha-ketobutyrate and ammonia. The catabolism of excess methionine is important to methionine homeostasis.O.I.H.G.
At1g69770843313CMT3 (chromomethylase 3)Encodes a chromomethylase involved in methylating cytosine residues at non-CG sites. Involved in preferentially methylating transposon-related sequences, reducing their mobility. CMT3 interacts with an Arabidopsis homologue of HP1 (heterochromatin protein 1), which in turn interacts with methylated histones. Involved in gene silencing.O.I.H.G.
At1g70310843367SPDS2 (spermidine synthase 2)Spermidine synthase.O.I.H.G.
At1g773308440691-aminocyclopropane-1-carboxylate oxidase, putative / ACC oxidase, putativesimilar to 1-aminocyclopropane-1-carboxylate oxidase GI:3386565 from (Sorghum bicolor)O.I.H.G.
At1g80740844413CMT1 (CHROMOMETHYLASE 1)ecotype Kl-0 chromomethylase (CMT1). A plant line expressing an RNAi construct directed against DMT4 has reduced agrobacterium-mediated tumor formation.O.I.H.G.
At2g19590816478ACO1 (ACC OXIDASE 1)encodes a protein whose sequence is similar to 1-aminocyclopropane-1-carboxylate oxidaseO.I.H.G.
At2g22810816812ACS4 (1-AMINOCYCLOPROPANE-1-CARBOXYLATE SYNTHASE 4)key regulatory enzyme in the biosynthesis of the plant hormone ethylene. ACS4 is specifically induced by indoleacetic acid (IAA).O.I.H.G.
At2g30970817648ASP1 (ASPARTATE AMINOTRANSFERASE 1)ASPARTATE AMINOTRANSFERASE 1O.I.H.G.
At2g36880818260MAT3 (methionine adenosyltransferase 3)F:copper ion binding, methionine adenosyltransferase activity;P:one-carbon compound metabolic process, S-adenosylmethionine biosynthetic process;C:plasma membrane;OBPMFAO.I.H.G.
At2g43750818978OASB (O-ACETYLSERINE (THIOL) LYASE B)Arabidopsis thaliana O-acetylserine (thiol) lyase (OAS-TL) isoform oasB, the key enzyme for fixation of inorganic sulfide. It catalyzes the formation of cysteine from O-acetylserine and inorganic sulfide.O.I.H.G.
At3g01120821292MTO1 (METHIONINE OVERACCUMULATION 1)encodes a cystathionine gamma-synthase, which performs the first committed step in methionine biosynthesis. A conserved motif of 13 amino acids in the first exon is required for posttranscriptional autoregulation. This enzyme shares the same substrate as threonine synthase (TS) and its absence transcriptionally affects 8 genes in the genome.O.I.H.G.
At3g02020821287AK3 (ASPARTATE KINASE 3)encodes a monofunctional aspartate kinaseO.I.H.G.
At3g02470821214SAMDC (S-ADENOSYLMETHIONINE DECARBOXYLASE)Encodes a S-adenosylmethionine decarboxylase involved in polyamine biosynthesis.O.I.H.G.
At3g03630821203CS26O-acetylserine (thiol) lyaseO.I.H.G.
At3g04940819654CYSD1 (CYSTEINE SYNTHASE D1)Encodes cysteine synthase CysD1.O.I.H.G.
At3g17390821003MTO3 (METHIONINE OVER-ACCUMULATOR 3)S-adenosylmethionine synthetaseO.I.H.G.
At3g22460821817OASA2 (O-ACETYLSERINE (THIOL) LYASE (OAS-TL) ISOFORM A1)Encodes a member of a family of genes with O-acetylserine(thiol)lyase activity.O.I.H.G.
At3g22740821845HMT3homocysteine S-methyltransferase (HMT3)O.I.H.G.
At3g23810821964SAHH2 (S-ADENOSYL-L-HOMOCYSTEINE (SAH) HYDROLASE 2)F:adenosylhomocysteinase activity, binding, catalytic activity;P:one-carbon compound metabolic process, metabolic process;C:plasma membrane, vacuole, membrane;OBMPAFO.I.H.G.
At3g25570822144adenosylmethionine decarboxylase family proteinF:adenosylmethionine decarboxylase activity;P:spermidine biosynthetic process, spermine biosynthetic process;C:cellular_component unknown;PMFOBO.I.H.G.
At3g25900822186HMT-1F:homocysteine S-methyltransferase activity;P:methionine biosynthetic process;C:cellular_component unknown;BOMPFAO.I.H.G.
At3g49700824132ACS9 (1-AMINOCYCLOPROPANE-1-CARBOXYLATE SYNTHASE 9)encodes a a member of the 1-aminocyclopropane-1-carboxylate (ACC) synthase (S-adenosyl-L-methionine methylthioadenosine-lyase, EC 4.4.1.14) gene family. Mutants produce elevated levels of ethylene as etiolated seedlings.O.I.H.G.
At3g57050824872CBL (cystathionine beta-lyase)Encodes second enzyme in the methionine biosynthetic pathwayO.I.H.G.
At3g59760825145OASC (O-ACETYLSERINE (THIOL) LYASE ISOFORM C)Arabidopsis thaliana O-acetylserine (thiol) lyase (OAS-TL) isoform oasCO.I.H.G.
At3g61440825317CYSC1 (CYSTEINE SYNTHASE C1)Encodes a cysteine synthase isomer CysC1. The isomer is however less effective in cysteine biosynthesis. It is involved in beta-cyanoalanine biosynthesis, an intermediate of cyanide detoxification pathway.O.I.H.G.
At3g61510825324ACS1 (ACC SYNTHASE 1)Encodes a member of the 1-aminocyclopropane-1-carboxylate (ACC) synthase (S-adenosyl-L-methionine methylthioadenosine-lyase, EC 4.4.1.14) gene family. The gene is transcriptionally active but enzymatically inactive. The predicted amino-acid sequence of ACS1 is missing the highly conserved tripeptide, Thr-Asn-Pro (TNP), between Ile204 and Ser205. Introduction of TNP into ACS1 restores the ACS activity.O.I.H.G.
At3g63250825500HMT2 (HOMOCYSTEINE METHYLTRANSFERASE 2)Encodes a homocysteine methyltransferase (HMT). Among the three HMT coding genes in the genome, HMT2 is responsible for a significant proportion of HMT activity in the flower stalks and silique hulls. However, HMT2 does not significantly contribute to the total HMT activity in seeds.O.I.H.G.
At4g08990826477DNA (cytosine-5-)-methyltransferase, putativeF:protein binding, DNA binding, DNA (cytosine-5-)-methyltransferase activity;P:DNA methylation;C:nucleus;BOMPFAVO.I.H.G.
At4g13610826994MEE57 (maternal effect embryo arrest 57)F:protein binding, DNA binding, DNA (cytosine-5-)-methyltransferase activity;P:embryonic development ending in seed dormancy, DNA methylation;C:nucleus;BOMPAFVO.I.H.G.
At4g14140827052DMT2 (DNA METHYLTRANSFERASE 2)This gene is predicted to encode a DNA methyltransferase. A plant line expressing an RNAi construct directed against DMT2 has reduced agrobacterium-mediated tumor formation.O.I.H.G.
At4g14710827122acireductone dioxygenase [iron(II)-requiring]/ metal ion bindingF:acireductone dioxygenase [iron(II)-requiring] activity, metal ion binding;P:methionine salvage;C:cellular_component unknown;PBMFOO.I.H.G.
At4g14716827124ATARD1 (ACIREDUCTONE DIOXYGENASE 1)F:acireductone dioxygenase [iron(II)-requiring] activity, metal ion binding;P:methionine salvage;C:cellular_component unknown;PBMFOO.I.H.G.
At4g17260827440L-lactate dehydrogenase, putativeF:in 6 functions;P:response to salt stress, response to abscisic acid stimulus;C:plasma membrane;BOMFPAO.I.H.G.
At4g19020827640CMT2 (chromomethylase 2)F:chromatin binding, DNA binding;P:chromatin assembly or disassembly, DNA methylation;C:chromatin, nucleus;BOMPFAVO.I.H.G.
At4g19710827715bifunctional aspartate kinase/homoserine dehydrogenase, putative / AK-HSDH, putativeEncodes a bifunctional aspartate kinase/homoserine dehydrogenase. These two activities catalyze the first and the third steps toward the synthesis of the essential amino acids threonine, isoleucine and methionine.O.I.H.G.
At4g31990829330ASP5 (ASPARTATE AMINOTRANSFERASE 5)encodes a plastid-localized aspartate aminotransferaseO.I.H.G.
At4g34840829636ATMTN2F:methylthioadenosine nucleosidase activity;P:nucleoside metabolic process;C:cellular_component unknown;BPOO.I.H.G.
At4g37770829933ACS8Encodes an auxin inducible ACC synthase.O.I.H.G.
At4g38800830035ATMTN1F:methylthioadenosine nucleosidase activity, catalytic activity;P:nucleoside metabolic process;C:plasma membrane;BOPO.I.H.G.
At5g11520831024ASP3 (ASPARTATE AMINOTRANSFERASE 3)Encodes the chloroplastic isozyme of aspartate aminotransferase. Involved in aspartate biosynthesis and nitrogen metabolism. mRNA is expressed in senescing leaves.O.I.H.G.
At5g13280831169AK-LYS1 (ASPARTATE KINASE 1)Asp kinase inhibited by Lys and S-adenosylmethionine. Contains regulatory domains that belong to the ACT domain family, which allow binding to a extreme variety of ligands. Can function as a monomer or as a dimer with acetohydroxyacid synthase (HSDH).O.I.H.G.
At5g14060831255CARAB-AK-LYSlysine-sensitive aspartate kinaseO.I.H.G.
At5g15950831452adenosylmethionine decarboxylase family proteinF:adenosylmethionine decarboxylase activity;P:spermidine biosynthetic process, spermine biosynthetic process, polyamine biosynthetic process;C:cellular_component unknown;PMFOBO.I.H.G.
At5g18930832011BUD2 (BUSHY AND DWARF 2)F:adenosylmethionine decarboxylase activity;P:spermidine biosynthetic process, spermine biosynthetic process, polyamine biosynthetic process;C:cellular_component unknown;PMFOBO.I.H.G.
At5g19550832075ASP2 (ASPARTATE AMINOTRANSFERASE 2)Nitrogen metabolism. Major cytosolic isoenzyme controlling aspartate biosynthesis in the light.O.I.H.G.
At5g20980832223ATMS3 (methionine synthase 3)encodes a plastidic methionine synthase, involved in methionine de novo synthesis in the chloroplastO.I.H.G.
At5g25480832623DNMT2 (DNA METHYLTRANSFERASE-2)Encodes a DNA methyltransferase homolog. Human Dnmt2 methylates tRNA-Asp and can methylate Arabidopsis tRNA-Asp in vitro.O.I.H.G.
At5g28030832873cysteine synthase, putative / O-acetylserine (thiol)-lyase, putative / O-acetylserine sulfhydrylase, putativeF:pyridoxal phosphate binding, cysteine synthase activity, catalytic activity;P:cysteine biosynthetic process from serine, cysteine biosynthetic process, metabolic process;C:unknown;BOFPMAO.I.H.G.
At5g36160833613aminotransferase-relatedF:1-aminocyclopropane-1-carboxylate synthase activity, pyridoxal phosphate binding, transferase activity, transferring nitrogenous groups, transaminase activity, catalytic activity;P:tyrosine catabolic process to phosphoenolpyruvate, cellular amino acid and derivative metabolic process, biosynthetic process;C:cellular_component unknown;BOPMAFO.I.H.G.
At5g49160834975MET1 (METHYLTRANSFERASE 1)Encodes a cytosine methyltransferase MET1. Required for silencing of FWA paternal allele in endosperm. Two lines with RNAi constructs directed against DMT1 have reduced agrobacterium-mediated tumor formation.O.I.H.G.
At5g53120835392SPDS3 (SPERMIDINE SYNTHASE 3)encodes a novel spermine synthase and is a paralog of previously characterized spermidine synthases, SPDS1 and SPDS2. SPDS3 forms heterodimers with SDPS2, which in turn forms heterodimers with SDPS1 in vivo. The gene does not complement speDelta3 deficiency of spermidine synthase in yeast but DOES complement speDelta4 deficiency.O.I.H.G.
At5g53970835480aminotransferase, putativeencodes tyrosine aminotransferase which is strongly induced upon aging and coronatine treatmentO.I.H.G.
At5g56760835778ATSERAT1Encodes a cytosolic serine O-acetyltransferase involved in sulfur assimilation and cysteine biosynthesis. Expressed in the vascular system.O.I.H.G.
At5g65800836709ACS5 (ACC SYNTHASE 5)1-aminocyclopropane-1-carboxylate synthase (ACS) is encoded by a multigene family consisting of at least five members whose expression is induced by hormones, developmental signals, and protein synthesis inhibition.O.I.H.G.

Comparison with co-expressed genes



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