Metabolic pathway to genes

Genes assigned in the pathway

Query pathway ID 00250
Pathway name Alanine, aspartate and glutamate metabolism
Organism Arabidopsis_thaliana
Database KEGG PATHWAY

Click Gene ID to show a list of co-expressed genes.

Gene ID Repr. ID Gene name Functional description O.I. H.G. Other DB
At1g17290838301AlaAT1 (ALANINE AMINOTRANSFERAS)Encodes for alanine aminotransferase (ALAAT1), involved in alanine catabolism during plants recovery from hypoxiaO.I.H.G.
At1g23310838940GGT1 (GLUTAMATE:GLYOXYLATE AMINOTRANSFERASE)Identified by cloning the gene that corresponded to a purified protein having glyoxylate aminotransferase activity. Localized to the peroxisome and thought to be involved in photorespiration/ metabolic salvage pathway.O.I.H.G.
At1g29900839868CARB (CARBAMOYL PHOSPHATE SYNTHETASE B)carbamoyl phosphate synthetase large chain (CARB) mRNA,O.I.H.G.
At1g36280840534adenylosuccinate lyase, putative / adenylosuccinase, putativeF:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity, catalytic activity;P:purine ribonucleotide biosynthetic process, purine base biosynthetic process, IMP biosynthetic process;C:chloroplast;BOMFAPO.I.H.G.
At1g48470841268GLN1Encodes cytosolic glutamine synthase isozyme. Expression of mRNA is not detectable in roots.O.I.H.G.
At1g51720841597glutamate dehydrogenase, putativeF:oxidoreductase activity, binding, catalytic activity;P:amino acid metabolic process, metabolic process;C:cellular_component unknown;BOMPAFO.I.H.G.
At1g62800842579ASP4 (ASPARTATE AMINOTRANSFERASE 4)Encodes aspartate aminotransferase (Asp4).O.I.H.G.
At1g70580843395AOAT2 (ALANINE-2-OXOGLUTARATE AMINOTRANSFERASE 2)Similar to glutamate-glyoxylate transaminase enzyme encoded by AOAT1O.I.H.G.
At1g79440844282ALDH5F1Encodes a mitochondrial succinic semialdehyde dehydrogenase (SSADH). Nomenclature according to Kirch, et al (2004).O.I.H.G.
At2g02000814731GAD3 (glutamate decarboxylase 3)F:calmodulin binding;P:carboxylic acid metabolic process, glutamate metabolic process, glutamate decarboxylation to succinate;C:cellular_component unknown;BFPOMAVO.I.H.G.
At2g16570816156ATASE1 (GLN PHOSPHORIBOSYL PYROPHOSPHATE AMIDOTRANSFERASE 1)Amidophosphoribosyltransferase (ATase: EC 2.4.2.14) is a key enzyme in the pathway of purine nucleotide biosynthesisO.I.H.G.
At2g30970817648ASP1 (ASPARTATE AMINOTRANSFERASE 1)ASPARTATE AMINOTRANSFERASE 1O.I.H.G.
At3g03910821072GDH3 (GLUTAMATE DEHYDROGENASE 3)GDH3 encodes a member of the glutamate dehydrogenease family. Its expression is upregulated in response to cytokinin and it may play a role in the control of nitrogen metabolism in leaf development.O.I.H.G.
At3g17760821044GAD5 (glutamate decarboxylase 5)F:calmodulin binding;P:carboxylic acid metabolic process, glutamate metabolic process, glutamate decarboxylation to succinate;C:cellular_component unknown;BFPOMAVO.I.H.G.
At3g17820821050ATGSKB6encodes a cytosolic glutamine synthetase, the enzyme has low affinity with substrate ammoniumO.I.H.G.
At3g20330821577aspartate carabmoyltransferase, chloroplast / aspartate transcarbamylase / ATCase (PYRB)encodes aspartate carbamoyltransferase catalyzing the second step in the de novo pyrimidine ribonucleotide biosynthesisO.I.H.G.
At3g24090821995glutamine-fructose-6-phosphate transaminase (isomerizing)/ sugar binding / transaminaseF:sugar binding, transaminase activity, glutamine-fructose-6-phosphate transaminase (isomerizing) activity;P:carbohydrate biosynthetic process, carbohydrate metabolic process, metabolic process;C:cytoplasm;OBMAFPVO.I.H.G.
At3g27740822396CARA (CARBAMOYL PHOSPHATE SYNTHETASE A)carbamoyl phosphate synthetase small subunit mRNA (carA),O.I.H.G.
At3g47340823888ASN1 (GLUTAMINE-DEPENDENT ASPARAGINE SYNTHASE 1)encodes a glutamine-dependent asparagine synthetase, the predicted ASN1 peptide contains a purF-type glutamine-binding domain, and is expressed predominantly in shoot tissues, where light has a negative effect on its mRNA accumulation. Expression is induced within 3 hours of dark treatment, in senescing leaves and treatment with exogenous photosynthesis inhibitor. Induction of gene expression was suppressed in excised leaves supplied with sugar. The authors suggest that the gene's expression pattern is responding to the level of sugar in the cell.O.I.H.G.
At3g57610824930ADSS (ADENYLOSUCCINATE SYNTHASE)encoding adenylosuccinate synthetase (AdSS), the enzyme involved in the first step of the formation of the purine nucleotide AMP (conversion of IMP to adenylo-succinate)O.I.H.G.
At4g18440827575adenylosuccinate lyase, putative / adenylosuccinase, putativeF:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity, catalytic activity;P:purine ribonucleotide biosynthetic process, purine base biosynthetic process, IMP biosynthetic process;C:chloroplast, chloroplast stroma;BOMFAPO.I.H.G.
At4g24830828586arginosuccinate synthase familyF:argininosuccinate synthase activity, ATP binding;P:arginine biosynthetic process;C:chloroplast stroma, chloroplast;OBMAFPO.I.H.G.
At4g31990829330ASP5 (ASPARTATE AMINOTRANSFERASE 5)encodes a plastid-localized aspartate aminotransferaseO.I.H.G.
At4g34740829626ATASE2 (GLN PHOSPHORIBOSYL PYROPHOSPHATE AMIDOTRANSFERASE 2)Encodes glutamine 5-phosphoribosylpyrophosphate amidotransferase. Mutants are deficient in leaf, but not cotyledon, plastid and palisade cell development. Mutants exhibit defective chloroplast development under non-low light, suggesting that the defect in chloroplast development is caused by photo-oxidative damage.O.I.H.G.
At4g38880830043ATASE3 (GLN PHOSPHORIBOSYL PYROPHOSPHATE AMIDOTRANSFERASE 3)GLN PHOSPHORIBOSYL PYROPHOSPHATE AMIDOTRANSFERASE 2O.I.H.G.
At4g39660830120AGT2 (ALANINE:GLYOXYLATE AMINOTRANSFERASE 2)alanine:glyoxylate aminotransferase 2 homolog (AGT2) mRNA,O.I.H.G.
At5g07440830635GDH2 (GLUTAMATE DEHYDROGENASE 2)Encodes the beta-subunit of the glutamate dehydrogenase. The enzyme is almost exclusively found in the mitochondria of stem and leaf companion cells.O.I.H.G.
At5g08100830704L-asparaginase / L-asparagine amidohydrolaseF:asparaginase activity;P:glycoprotein catabolic process;C:cellular_component unknown;BOMFPAO.I.H.G.
At5g10240830888ASN3 (ASPARAGINE SYNTHETASE 3)Encodes asparagine synthetase (ASN3).O.I.H.G.
At5g10920830959argininosuccinate lyase, putative / arginosuccinase, putativeF:argininosuccinate lyase activity, catalytic activity;P:arginine biosynthetic process via ornithine, arginine biosynthetic process;C:chloroplast, chloroplast stroma;BOAMFPO.I.H.G.
At5g11520831024ASP3 (ASPARTATE AMINOTRANSFERASE 3)Encodes the chloroplastic isozyme of aspartate aminotransferase. Involved in aspartate biosynthesis and nitrogen metabolism. mRNA is expressed in senescing leaves.O.I.H.G.
At5g14760831328AO (L-ASPARTATE OXIDASE)At5g14760 encodes for L-aspartate oxidase involved in the early steps of NAD biosynthesis. In contrary to the EC 1.4.3.16 (l-aspartate oxidase - deaminating) the enzyme catalyzes the reaction L-aspartate + O2 = iminoaspartate (alpha-iminosuccinate) + H2O2O.I.H.G.
At5g16570831519GLN1Encodes a cytosolic glutamine synthetase, the enzyme has high affinity with substrate ammoniumO.I.H.G.
At5g17330831599GADEncodes one of two isoforms of glutamate decarboxylase.O.I.H.G.
At5g18170831935GDH1 (GLUTAMATE DEHYDROGENASE 1)Encodes the 43 kDa alpha-subunit of the glutamate dehydrogenase with a putative mitochondrial transit polypeptide and NAD(H)- and alpha-ketoglutarate-binding domains. Mitochondrial localization confirmed by subcellular fractionation. Combines in several ratios with GDH2 protein (GDH-beta) to form seven isoenzymes. Catalyzes the cleavage of glycine residues. May be involved in ammonia assimilation under conditions of inorganic nitrogen excess. The enzyme is almost exclusively found in the mitochondria of stem and leaf companion cells.O.I.H.G.
At5g19550832075ASP2 (ASPARTATE AMINOTRANSFERASE 2)Nitrogen metabolism. Major cytosolic isoenzyme controlling aspartate biosynthesis in the light.O.I.H.G.
At5g35630833535GS2 (GLUTAMINE SYNTHETASE 2)chloroplastic glutamine synthetaseO.I.H.G.
At5g37600833738ATGSR1encodes a cytosolic glutamine synthetase, the enzyme has high affinity with substrate ammoniumO.I.H.G.
At5g53460835427GLT1NADH-dependent glutamate synthaseO.I.H.G.
At5g62530836373ALDH12A1Encodes mitochondrial Delta-pyrroline-5- carboxylate dehydrogenase. Involved in the catabolism of proline to glutamate. Involved in protection from proline toxicity. Induced at pathogen infection sites. P5CDH and SRO5 (an overlapping gene in the sense orientation) generate 24-nt and 21-nt siRNAs, which together are components of a regulatory loop controlling reactive oxygen species (ROS) production and stress response.O.I.H.G.
At5g65010836625ASN2 (ASPARAGINE SYNTHETASE 2)Encodes asparagine synthetase (ASN2).O.I.H.G.

Comparison with co-expressed genes



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