Metabolic pathway to genes

Genes assigned in the pathway

Query pathway ID 00100
Pathway name Steroid biosynthesis
Organism Arabidopsis_thaliana

Click Gene ID to show a list of co-expressed genes.

Gene ID Repr. ID Gene name Functional description O.I. H.G. Other DB
At1g07420837254SMO2-1 (STEROL 4-ALPHA-METHYL-OXIDASE 2-1)Arabidopsis thaliana sterol 4-alpha-methyl-oxidase mRNAO.I.H.G.
At1g11680837712CYP51G1 (CYTOCHROME P450 51G1)putative obtusifoliol 14-alpha demethylase involved in sterol biosynthesis.O.I.H.G.
At1g20050838593HYD1 (HYDRA1)C-8 sterol isomeraseO.I.H.G.
At1g20330838621SMT2 (STEROL METHYLTRANSFERASE 2)Encodes a sterol-C24-methyltransferases involved in sterol biosynthesis. Mutants display altered sterol composition, serrated petals and sepals and altered cotyledon vascular patterning as well as ectopic endoreduplication. This suggests that suppression of endoreduplication is important for petal morphogenesis and that normal sterol composition is required for this suppression.O.I.H.G.
At1g50430841465DWF5 (DWARF 5)Mutants are defective in Brassinosteroid biosynthesis (delta7-sterol-C7 reduction step) and have a dwarf phenotype.O.I.H.G.
At1g58440842213XF1Encodes a putative protein that has been speculated, based on sequence similarities, to have squalene monooxygenase activity.O.I.H.G.
At1g76090843941SMT3 (STEROL METHYLTRANSFERASE 3)Encodes S-adenosyl-methionine-sterol-C-methyltransferase, an enzyme in the sterol biosynthetic pathway.O.I.H.G.
At1g78960844236ATLUP2Encodes a multifunctional 2-3-oxidosqualene (OS)-triterpene cyclase that can cyclize OS into lupeol, alpha- and beta-amyrin.O.I.H.G.
At2g07050815275CAS1 (cycloartenol synthase 1)Involved in the biosynthesis of brassinosteroids. Catalyzes the reaction from epoxysqualene to cycloartenol.O.I.H.G.
At2g28850817434CYP710A3 (cytochrome P450, family 710, subfamily A, polypeptide 3)member of CYP710AO.I.H.G.
At2g28860817435CYP710A4 (cytochrome P450, family 710, subfamily A, polypeptide 4)member of CYP710AO.I.H.G.
At2g34490818012CYP710A2 (cytochrome P450, family 710, subfamily A, polypeptide 2)Encodes a protein with C22-sterol desaturase activity. The enzyme was shown to catalyze the conversion of both 24-epi-campesterol and β-sitosterol to brassicasterol and stigmasterol, respectively, in the presence of NADPH.O.I.H.G.
At2g34500818013CYP710A1 (cytochrome P450, family 710, subfamily A, polypeptide 1)Encodes a protein with C22-sterol desaturase activity. The enzyme was shown to catalyze in the presence of NADPH the conversion of β-sitosterol to stigmasterol, but not that of 24-epi-campesterol to brassicasterol (unlike CYP710A2).O.I.H.G.
At3g02580820679STE1 (STEROL 1)Brassinosteroid biosynthetic enzyme, catalyzes delta7 sterol C-5 desaturation step. Mutant has dwarf phenotype.O.I.H.G.
At3g19820821519DWF1 (DWARF 1)Involved in the conversion of the early brassinosteroid precursor 24-methylenecholesterol to campesterol. Brassinosteroids affect cellular elongation. Mutants have dwarf phenotype. DWF1 is a Ca2+-dependent calmodulin-binding protein.O.I.H.G.
At3g45130823649LAS1F:lanosterol synthase activity;P:pentacyclic triterpenoid biosynthetic process;C:cellular_component unknown;BPOFMAO.I.H.G.
At3g52940824460FK (FACKEL)Encodes a sterol C-14 reductase required for cell division and expansion and is involved in proper organization of the embryo.O.I.H.G.
At4g15340827200ATPEN1 (ARABIDOPSIS THALIANA PENTACYCLIC TRITERPENE SYNTHASE 1)Encodes a protein that catalyzes the production of the tricyclic triterpene arabidiol when expressed in yeast.O.I.H.G.
At4g34640829616SQS1 (SQUALENE SYNTHASE 1)Encodes squalene synthase, which converts two molecules of farnesyl diphosphate (FPP) into squalene via an intermediate: presqualene diphosphate (PSPP). It is generally thought to be one of the key enzymes of sterol biosynthesis, since it catalyzes the first pathway-specific reaction of the sterol branch of the isoprenoid pathway.O.I.H.G.
At4g34650829617SQS2 (SQUALENE SYNTHASE 2)Encodes a protein with similarity to squalene synthase which catalyzes the first committed step in sterol biosynthesis. To date no experimental evidence exists that SQS2 functions as a squalene synthase and some experiments indicate it does not have this function.O.I.H.G.
At4g37760829932SQE3 (squalene epoxidase 3)F:squalene monooxygenase activity;P:response to jasmonic acid stimulus, sterol biosynthetic process, response to wounding;C:endomembrane system, integral to membrane;BOFMPAO.I.H.G.
At5g13710831216SMT1 (STEROL METHYLTRANSFERASE 1)SMT1 controls the level of cholesterol in plantsO.I.H.G.
At5g24140832479SQP2Encodes a protein with similarity to squalene monoxygenases.O.I.H.G.
At5g36150833612ATPEN3 (putative pentacyclic triterpene synthase 3)F:lupeol synthase activity, catalytic activity;P:pentacyclic triterpenoid biosynthetic process;C:cellular_component unknown;BPOFMO.I.H.G.
At5g42600834267MRN1 (MARNERAL SYNTHASE)Encodes an oxidosqualene synthase that produces the monocyclic triterpene marneral.O.I.H.G.
At5g50375835105CPI1 (CYCLOPROPYL ISOMERASE)Converts pentacyclic cyclopropyl sterols to conventional tetracyclic sterols. CPI1 function during and just after division and support gravitropism by establishing polar PIN2 localization. Required for endocytosis of PIN2O.I.H.G.

Comparison with co-expressed genes

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