Metabolic pathway to genes

Genes assigned in the pathway

Query pathway ID 00071
Pathway name Fatty acid metabolism
Organism Arabidopsis_thaliana
Database KEGG PATHWAY

Click Gene ID to show a list of co-expressed genes.

Gene ID Repr. ID Gene name Functional description O.I. H.G. Other DB
At1g04710839434PKT4 (PEROXISOMAL 3-KETOACYL-COA THIOLASE 4)EC2.3.1.16 thiolase.O.I.H.G.
At1g06290837140ACX3 (ACYL-COA OXIDASE 3)Encodes an acyl-CoA oxidase with specificity for medium chain fatty acids.O.I.H.G.
At1g06310837141ACX6 (ACYL-COA OXIDASE 6)Encodes a putative acyl-CoA oxidase. However, no transcripts have been detected for this gene and no altered phenotypes have been detected in plants mutant for this gene. This suggests that ACX6 does not significantly contribute to seedling beta-oxidation of fatty acids or indole-3-butyric acid in vivo.O.I.H.G.
At1g22430838849alcohol dehydrogenase, putativeF:oxidoreductase activity, binding, catalytic activity, zinc ion binding;P:oxidation reduction, metabolic process;C:cellular_component unknown;BOPFMAVO.I.H.G.
At1g22440838850alcohol dehydrogenase, putativeF:oxidoreductase activity, binding, catalytic activity, zinc ion binding;P:oxidation reduction, metabolic process;C:cellular_component unknown;BOPFMAVO.I.H.G.
At1g23800838991ALDH2B7Encodes a mitochondrial aldehyde dehydrogenase; nuclear gene for mitochondrial product.O.I.H.G.
At1g32780840172alcohol dehydrogenase, putativeF:oxidoreductase activity, binding, catalytic activity, zinc ion binding;P:oxidation reduction, metabolic process;C:unknown;BOPFMAVO.I.H.G.
At1g49430841367LACS2 (LONG-CHAIN ACYL-COA SYNTHETASE 2)Encodes a long chain acyl-CoA synthetase that catalyzes the synthesis of omega-hydroxy fatty acyl-CoA intermediates in the pathway to cutin synthesis. Required for repression of lateral root formation.O.I.H.G.
At1g54100841849ALDH7B4 (Aldehyde Dehydrogenase 7B4)Aldehyde dehydrogenaseO.I.H.G.
At1g64400842748long-chain-fatty-acid--CoA ligase, putative / long-chain acyl-CoA synthetase, putativeF:catalytic activity;P:fatty acid biosynthetic process;C:unknown;BOMFPAVO.I.H.G.
At1g64710842779alcohol dehydrogenase, putativeF:oxidoreductase activity, binding, zinc ion binding, catalytic activity;P:oxidation reduction, metabolic process;C:unknown;BOPFMAVO.I.H.G.
At1g77120844047ADH1 (ALCOHOL DEHYDROGENASE 1)Catalyzes the reduction of acetaldehyde using NADH as reductant. Requires zinc for activity. Dimer. Anaerobic response polypeptide (ANP). Fermentation. The protein undergoes thiolation following treatment with the oxidant tert-butylhydroperoxide.O.I.H.G.
At1g77590844094LACS9 (LONG CHAIN ACYL-COA SYNTHETASE 9)Encodes major plastidic long chain acyl-CoA synthetase with a slight substrate preference of oleic acid over any of the other fatty acids.O.I.H.G.
At2g33150817876PKT3 (PEROXISOMAL 3-KETOACYL-COA THIOLASE 3)Encodes an organellar (peroxisome, glyoxysome) 3-ketoacyl-CoA thiolase, involved in fatty acid b-oxidation during germination and subsequent seedling growth. Mutants have defects in glyoxysomal fatty acid beta-oxidation. EC2.3.1.16 thiolase.O.I.H.G.
At2g35690818138ACX5 (ACYL-COA OXIDASE 5)Encodes an acyl-CoA oxidase. Involved in jasmonate biosynthesis. Expressed uniformly in seedlings and throughout development.O.I.H.G.
At3g05970819767LACS6 (long-chain acyl-CoA synthetase 6)encode peroxisomal long-chain acyl-CoA synthetase (LACS) isozymesO.I.H.G.
At3g06810819865IBR3 (IBA-RESPONSE 3)Encodes a protein with similarity to acyl-CoA dehydrogenases. Mutations in IBR3 render plants resistant to indole-3-butryic acid, a putative storage form of the biologically active auxin IAA (indole-3-acetic acid). IBR3 is hypothesized to carry out the second step in a β-oxidation-like process of IBA metabolism in Arabidopsis. Though its subcellular location has not been determined, IBR3 has a peroxisomal targeting sequence and two other putative IBA metabolic enzymes (IBR1 and IBR10) can be found in this organelle. No specific enzymatic activity has been documented for IBR3, but double mutant analyses with CHY1 argue against a role for IBR3 in general fatty acid β-oxidation.O.I.H.G.
At3g48000823955ALDH2B4 (ALDEHYDE DEHYDROGENASE 2B4)Encodes a putative (NAD+) aldehyde dehydrogenase.O.I.H.G.
At3g51840824347ACX4 (ACYL-COA OXIDASE 4)Encodes a short-chain acyl-CoA oxidase, which catalyzes the first step of peroxisomal fatty acid beta-oxidation during early, post-germinative growth in oilseed species. Null mutants virtually lack short-chain acyl-CoA and are resistant to 2,4-dichlorophenoxybutyric acid, which is converted to the herbicide and auxin analogue 2,4-dichlorophenoxyacetic acid by beta-oxidation. Despite the almost complete loss of short-chain activity, lipid catabolism and seedling growth and establishment was unaltered in the acx4 mutant. However, double mutants in acx3acx4 (acx3 encodes medium chain acyl CoA oxidase) were not viable and arrested during embryogenesis.O.I.H.G.
At4g11030826704long-chain-fatty-acid--CoA ligase, putative / long-chain acyl-CoA synthetase, putativeF:catalytic activity;P:fatty acid biosynthetic process;C:unknown;BOMFPAVO.I.H.G.
At4g14070827043AAE15 (acyl-activating enzyme 15)Plastidic acyl activating enzyme involved in the elongation of exogenous medium-chain fatty acids to 16- and 18-carbon fatty acids.O.I.H.G.
At4g16210827314ECHIA (ENOYL-COA HYDRATASE/ISOMERASE A)F:catalytic activity;P:metabolic process;C:peroxisome;BOMFPAO.I.H.G.
At4g16760827381ACX1 (ACYL-COA OXIDASE 1)Encodes a medium to long-chain acyl-CoA oxidase. Catalyzes the first step of fatty acid beta-oxidation. Involved in jasmonate biosynthesis. Gene expression is induced by wounding, drought stress, abscisic acid, and jasmonate.O.I.H.G.
At4g16800827386enoyl-CoA hydratase, putativeF:enoyl-CoA hydratase activity, catalytic activity;P:fatty acid metabolic process, metabolic process;C:cellular_component unknown;BOMFPAO.I.H.G.
At4g23850828484long-chain-fatty-acid--CoA ligase / long-chain acyl-CoA synthetaseF:catalytic activity;P:fatty acid biosynthetic process;C:plasma membrane;BOMFPAVO.I.H.G.
At4g34240829573ALDH3I1 (ALDEHYDE DEHYDROGENASE 3|1)Aldehyde dehydrogenase induced by ABA and dehydrationO.I.H.G.
At5g27600832820LACS7 (LONG-CHAIN ACYL-COA SYNTHETASE 7)Encode peroxisomal long-chain acyl-CoA synthetase. Activates fatty acids for further metabolism. Interacts with PEX5.O.I.H.G.
At5g42250834230alcohol dehydrogenase, putativeF:oxidoreductase activity, binding, catalytic activity, zinc ion binding;P:oxidation reduction, metabolic process;C:unknown;BOPFMAVO.I.H.G.
At5g43940834417HOT5 (sensitive to hot temperatures 5)Encodes a glutathione-dependent formaldehyde dehydrogenase (also known as class III type alcohol dehydrogenase) reduces S-nitrosoglutathione (GSNO), the condensation product of glutathione and NO, that is a naturally occurring NO reservoir and also a reactive nitrogen intermediate. Gene expression is reduced by wounding and induced by salicylic acid. Is required for the acclimation of plants to high temperature and for fertility.O.I.H.G.
At5g48230834876ACAT2 (ACETOACETYL-COA THIOLASE 2)F:acetyl-CoA C-acetyltransferase activity, catalytic activity;P:embryonic development ending in seed dormancy;C:peroxisome, plasma membrane;BOMFAPO.I.H.G.
At5g48880834946PKT2 (PEROXISOMAL 3-KETO-ACYL-COA THIOLASE 2)Encodes a peroxisomal 3-keto-acyl-CoA thiolase 2 precursor. EC2.3.1.16 thiolases. AT5G48880.1 is named PKT1 and AT5G48880.2 is named PKT2.O.I.H.G.
At5g65110836635ACX2 (ACYL-COA OXIDASE 2)Encodes an acyl-CoA oxidase presumably involved in long chain fatty acid biosynthesis.O.I.H.G.

Comparison with co-expressed genes



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