Biological process to genes

Query process ID GO:0031348
Process name Any process that stops, prevents or reduces the frequency, rate or extent of a defense response.
Organism Arabidopsis thaliana

Click Gene ID to show a list of co-expressed genes.

ECC Gene ID Repr. ID Gene name Functional description O.I. H.G. Other DB
XAt1g11310837673MLO2 (MILDEW RESISTANCE LOCUS O 2)A member of a large family of seven-transmembrane domain proteins specific to plants, homologs of the barley mildew resistance locus o (MLO) protein. The Arabidopsis genome contains 15 genes encoding MLO proteins, with localization in plasma membrane. Phylogenetic analysis revealed four clades of closely-related AtMLO genes. ATMLO2 belongs to the clade IV, with AtMLO3, AtMLO6 and AtMLO12. The gene is expressed during early seedling growth, in roots, in vascular system of cotyledons and young leaves,and in fruit abscission zone; it was not expressed in anthers and pollen, as shown by GUS activity patterns. The expression of several phylogenetically closely-related AtMLO genes showed similar or overlapping tissue specificity and analogous responsiveness to external stimuli, suggesting functional redundancy, co-function, or antagonistic function(s). mlo resistance in A. thaliana does not involve the signaling molecules ethylene, jasmonic acid or salicylic acid, but requires a syntaxin, glycosyl hydrolase and ABC transporter.O.I.H.G.
XAt1g59870842281PEN3 (PENETRATION 3)ATP binding cassette transporter. Localized to the plasma membrane in uninfected cells. In infected leaves, the protein concentrated at infection sites. Contributes to nonhost resistance to inappropriate pathogens that enter by direct penetration in a salicylic acid–dependent manner. Required for mlo resistance. Has Cd transporter activity (Cd2+ extrusion pump) and contributes to heavy metal resistance.O.I.H.G.
XAt1g64280842733NPR1 (NONEXPRESSER OF PR GENES 1)This gene is a key regulator of the salicylic acid (SA)-mediated systemic acquired resistance (SAR) pathway. It is similar to the transcription factor inhibitor I kappa B, and contains ankyrin repeats. It confers resistance to the pathogens Pseudomonas syringae and Peronospora parasitica in a dosage-dependent fashion. Although transgenic Arabidopsis plants overexpressing NPR1 acquire enhanced sensitivity to SA and (benzothiadiazole) BTH, they display no obvious detrimental morphological changes and do not have elevated pathogenesis-related gene expression until activated by inducers or pathogens.O.I.H.G.
XAt1g74710843810isochorismate synthase 1 (ICS1) / isochorismate mutaseEncodes a protein with isochorismate synthase activity. Mutants fail to accumulate salicylic acid. Its function may be redundant with that of ICS2 (AT1G18870).O.I.H.G.
XAt1g77470844083replication factor C 36 kDA, putativeF:in 6 functions;P:DNA replication;C:DNA replication factor C complex;BOMFAPVO.I.H.G.
XAt2g39940818581COI1 (CORONATINE INSENSITIVE 1)Encodes a protein containing Leu-rich repeats and a degenerate F-box motif. Associates with AtCUL1, AtRbx1, and the Skp1-like proteins ASK1 and ASK2 to assemble SCF COI1 ubiquitin-ligase complexes in planta. A single amino acid substitution in the F-box motif of COI1 abolishes the formation of the SCF(COI1) complexes and results in loss of the JA response. Required for wound- and jasmonates-induced transcriptional regulation.O.I.H.G.
XAt2g46370819244JAR1 (JASMONATE RESISTANT 1)Encodes a jasmonate-amido synthetase that is a member of the GH3 family of proteins. JAR1 catalyzes the formation of a biologically active jasmonyl-isoleucine (JA-Ile) conjugate. JA-Ile promotes the interaction between JAZ1 and COI1 in the jasmonate signaling pathway. JAR1 localizes to the cytoplasm and is also a phytochrome A signaling component. JAR1 is an auxin-induced gene. Loss of function mutants are defective in a variety of responses to jasmonic acid. JAR1 has additional enzymatic activities in vitro, (e.g. the ability to synthesize adenosine 5'-tetraphosphate and other JA conjugates), but there are no data to show whether JAR1 catalyzes many of these reactions in vivo. JAR1 is involved in pathogen defense, sensitivity to ozone, and wound responses.O.I.H.G.
XAt3g11820820355SYP121 (SYNTAXIN OF PLANTS 121)Encodes a syntaxin localized at the plasma membrane (SYR1, Syntaxin Related Protein 1, also known as SYP121, PENETRATION1/PEN1). SYR1/PEN1 is a member of the SNARE superfamily proteins. SNARE proteins are involved in cell signaling, vesicle traffic, growth and development. SYR1/PEN1 functions in positioning anchoring of the KAT1 K+ channel protein at the plasma membrane. Transcription is upregulated by abscisic acid, suggesting a role in ABA signaling. Also functions in non-host resistance against barley powdery mildew, Blumeria graminis sp. hordei. SYR1/PEN1 is a nonessential component of the preinvasive resistance against Colletotrichum fungus. Required for mlo resistance.O.I.H.G.
XAt3g52430824408PAD4 (PHYTOALEXIN DEFICIENT 4)Encodes a lipase-like gene that is important for salicylic acid signaling and function in resistance (R) gene-mediated and basal plant disease resistance. PAD4 can interact directly with EDS1, another disease resistance signaling protein. Expressed at elevated level in response to green peach aphid (GPA) feeding, and modulates the GPA feeding-induced leaf senescence through a mechanism that doesn't require camalexin synthesis and salicylic acid (SA) signaling.O.I.H.G.
XAt3g61190825291BAP1 (BON ASSOCIATION PROTEIN 1)Encodes a protein with a C2 domain that binds to BON1 in yeast two hybrid analyses. Its ability to bind to phospholipids is enhanced by calcium ions. Involved in maintaining cell homeostasis.O.I.H.G.
XAt4g12560826869F-box family proteinF:molecular_function unknown;P:biological_process unknown;C:cellular_component unknown;POO.I.H.G.
XAt4g37460829901SRFR1 (SUPPRESSOR OF RPS4-RLD 1)Encodes a tetratricopeptide repeat domain containing protein that shows sequence similarity to those of transcriptional repressors in other organisms.Involved in mediating effector-triggered immunity.O.I.H.G.
XAt4g39030830058EDS5 (ENHANCED DISEASE SUSCEPTIBILITY 5)Encodes an orphan multidrug and toxin extrusion transporter. Essential component of salicylic acid-dependent signaling for disease resistance. Member of the MATE-transporter family. Expression induced by salicylic acid. Mutants are salicylic acid-deficient.O.I.H.G.
XAt5g03280831889EIN2 (ETHYLENE INSENSITIVE 2)Involved in ethylene signal transduction. Acts downstream of CTR1. Positively regulates ORE1 and negatively regulates mir164A,B,C to regulate leaf senescence.O.I.H.G.



The upper GO terms

Process ID Gene number Process name
GO:003134710Any process that modulates the frequency, rate or extent of a defense response.
GO:00485850Any process that stops, prevents or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.



The lower GO terms

Process ID Gene number Process name
GO:00458240Any process that stops, prevents or reduces the frequency, rate or extent of the innate immune response.
GO:00506871Any process that stops, prevents or reduces the rate or extent of antiviral mechanisms, thereby facilitating viral replication.
GO:00507280Any process that stops, prevents or reduces the frequency, rate or extent of the inflammatory response.
GO:00512452Any process that stops, prevents, or reduces the rate of the cellular defense response.
GO:00522610Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the defense response of a second organism, where the two organisms are in a symbiotic interaction.





Comparison with co-expressed genes



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