Biological process to genes

Query process ID GO:0009813
Process name The chemical reactions and pathways resulting in the formation of flavonoids, a group of phenolic derivatives containing a flavan skeleton.
Organism Arabidopsis thaliana

Click Gene ID to show a list of co-expressed genes.

ECC Gene ID Repr. ID Gene name Functional description O.I. H.G. Other DB
XAt1g43620840946UDP-glucose:sterol glucosyltransferase, putativeF:transferase activity, transferring glycosyl groups;P:lipid glycosylation, carbohydrate metabolic process, metabolic process;C:plasma membrane, vacuole;BMFPOVO.I.H.G.
XAt2g40890818686CYP98A3 (cytochrome P450, family 98, subfamily A, polypeptide 3)encodes coumarate 3-hydroxylase (C3H), a P450-dependent monooxygenase. Involved in lignin biosynthesis and flavonoid biosynthesis. Also affects the biosynthesis of coumarins such as scopoletin and scopolin as a branching-out-pathway from the phenylpropanoid acid level.O.I.H.G.
XAt2g45400819146BEN1involved in the regulation of brassinosteroid metabolic pathwayO.I.H.G.
XAt2g47460819359MYB12 (MYB DOMAIN PROTEIN 12)"MYB12 belongs to subgroup 7 of the R2R3-MYB family. It strongly activates the promoters of chalcone synthase (CHS), flavanone 3-hydroxylase (F3H), flavonol synthase (FLS) and - to a lesser extent - chalcone flavanone isomerase (CHI), but cannot activate the promoters of flavonoid-3'hydroxylase (F3'H) and dihydroflavonol 4-reductase (DF). The activation requires a functional MYB recognition element (MRE). Results from the myb12-1f allele indicate that an activation domain might be present in the C-terminus. Overexpression or knock-out plants do not show any obvious phenotype under greenhouse conditions. Young myb12-ko seedlings contain reduced amounts of flavonoids (quercetin and kaempferol), while seedlings as well as leaves of MYB12-OX plants displayed an increased flavonoid content. They did not show any significant difference in anthocyanin content. Expression of CHS and FLS shows a clear correlation to MYB12 expression levels. CHI and F3H show increased transcript levels in the MYB12-OX lines, but no differences in the knock-out. Even in the absence of functional MYB12, flavonol biosynthesis is not completely absent, suggesting functional redundancy. " The redundant factors are MYB11 and MYB111 although MYB12 is primarily required for flavonol biosynthesis in roots.O.I.H.G.
XAt3g51240824287F3H (FLAVANONE 3-HYDROXYLASE)Encodes flavanone 3-hydroxylase that is coordinately expressed with chalcone synthase and chalcone isomerases. Regulates flavonoid biosynthesis.O.I.H.G.
XAt3g55120824678TT5 (TRANSPARENT TESTA 5)Catalyzes the conversion of chalcones into flavanones. Required for the accumulation of purple anthocyanins in leaves and stems.O.I.H.G.
XAt5g08640830765FLS (FLAVONOL SYNTHASE)Encodes a flavonol synthase that catalyzes formation of flavonols from dihydroflavonols.O.I.H.G.
XAt5g13930831241TT4 (TRANSPARENT TESTA 4)Encodes chalcone synthase (CHS), a key enzyme involved in the biosynthesis of flavonoids. Required for the accumulation of purple anthocyanins in leaves and stems. Also involved in the regulation of auxin transport and the modulation of root gravitropism.O.I.H.G.
XAt5g66220836754chalcone isomeraseF:chalcone isomerase activity;P:flavonoid biosynthetic process;C:unknown;PO.I.H.G.
SAt5g07990830693TT7 (TRANSPARENT TESTA 7)Required for flavonoid 3' hydroxylase activity.O.I.H.G.
CAt1g17010838271oxidoreductase, 2OG-Fe(II) oxygenase family proteinF:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors, oxidoreductase activity, iron ion binding;P:flavonoid biosynthetic process;C:cellular_component unknown;POBFMO.I.H.G.
CAt1g17020838272SRG1 (SENESCENCE-RELATED GENE 1)Encodes a novel member of the Fe(II)/ascorbate oxidase gene family; senescence-related gene.O.I.H.G.
CAt1g49390841362oxidoreductase, 2OG-Fe(II) oxygenase family proteinF:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors, oxidoreductase activity;P:flavonoid biosynthetic process;C:cellular_component unknown;POBFMO.I.H.G.
CAt3g19010821434oxidoreductase, 2OG-Fe(II) oxygenase family proteinF:flavonol synthase activity, oxidoreductase activity, iron ion binding;P:flavonoid biosynthetic process;C:cellular_component unknown;POBFMO.I.H.G.
CAt4g16330827327oxidoreductase/ oxidoreductase, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donorsF:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors, oxidoreductase activity;P:flavonoid biosynthetic process;C:peroxisome;POBFMO.I.H.G.
CAt4g16770827383iron ion binding / oxidoreductase/ oxidoreductase, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donorsF:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors, oxidoreductase activity, iron ion binding;P:flavonoid biosynthetic process;C:peroxisome;POBFMO.I.H.G.
CAt4g25300828633oxidoreductase, 2OG-Fe(II) oxygenase family proteinF:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors, oxidoreductase activity;P:flavonoid biosynthetic process;C:cellular_component unknown;POBFMO.I.H.G.
CAt4g25310828634oxidoreductase, 2OG-Fe(II) oxygenase family proteinF:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors, oxidoreductase activity;P:flavonoid biosynthetic process;C:cellular_component unknown;POBFMO.I.H.G.
CAt5g07480830640oxidoreductase, 2OG-Fe(II) oxygenase family proteinF:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors, oxidoreductase activity;P:flavonoid biosynthetic process;C:cellular_component unknown;POBFMO.I.H.G.
CAt5g20550832177oxidoreductase, 2OG-Fe(II) oxygenase family proteinF:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors, oxidoreductase activity;P:flavonoid biosynthetic process;C:cellular_component unknown;POBFMO.I.H.G.
CAt5g24530832524DMR6 (DOWNY MILDEW RESISTANT 6)Encodes a putative 2OG-Fe(II) oxygenase that is defense-associated but required for susceptibility to downy mildew.O.I.H.G.
CAt5g63580836477FLS2 (FLAVONOL SYNTHASE 2)encodes a protein whose sequence is similar to flavonol synthaseO.I.H.G.
CAt5g63590836478FLS3 (FLAVONOL SYNTHASE 3)F:flavonol synthase activity;P:response to light stimulus, response to sucrose stimulus, flavonoid biosynthetic process;C:cellular_component unknown;POBFMO.I.H.G.
CAt5g63595836479FLS4 (FLAVONOL SYNTHASE 4)F:flavonol synthase activity, oxidoreductase activity;P:flavonoid biosynthetic process;C:cellular_component unknown;POBFMO.I.H.G.
CAt5g63600836480FLS5 (FLAVONOL SYNTHASE 5)encodes a protein whose sequence is similar to flavonol synthaseO.I.H.G.
LAt1g53520841787chalcone-flavanone isomerase-relatedF:chalcone isomerase activity;P:flavonoid biosynthetic process;C:chloroplast stroma, chloroplast;POBFO.I.H.G.
LAt2g26310817171chalcone isomeraseF:chalcone isomerase activity;P:flavonoid biosynthetic process;C:cellular_component unknown;PFOO.I.H.G.
LAt3g63170825492chalcone isomeraseF:chalcone isomerase activity;P:flavonoid biosynthetic process;C:mitochondrion, chloroplast, plastid, chloroplast envelope;PBOO.I.H.G.
LAt5g05270830409chalcone-flavanone isomerase family proteinF:chalcone isomerase activity;P:flavonoid biosynthetic process;C:cellular_component unknown;PO.I.H.G.



The upper GO terms

Process ID Gene number Process name
GO:000969911The chemical reactions and pathways resulting in the formation of aromatic derivatives of trans-cinnamic acid.
GO:00098120The chemical reactions and pathways involving flavonoids, a group of water-soluble phenolic derivatives containing a flavan skeleton including flavones, flavonols and flavanoids, and anthocyanins.



The lower GO terms

Process ID Gene number Process name
GO:00097160The chemical reactions and pathways resulting in the formation of flavonoid phytoalexins, a group of water-soluble phenolic derivatives containing a flavan skeleton, which possess antibiotic activity and are produced by plant tissues in response to infection.
GO:00097170The chemical reactions and pathways resulting in the formation of isoflavonoids, a group of water-soluble phenolic derivatives, isomeric with flavonoids.
GO:000971810The chemical reactions and pathways resulting in the formation of anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins.
GO:00100235The chemical reactions and pathways resulting in the formation of proanthocyanidin.
GO:00515510The chemical reactions and pathways resulting in the formation of aurones, a series of yellow plant pigments.
GO:00515530The chemical reactions and pathways resulting in the formation of flavones, a class of pigmented plant compounds based on 2-phenyl-4H-1-benzopyran-4-one (2-phenylchromone).
GO:00515570The chemical reactions and pathways resulting in the formation of leucoanthocyanidins, a class of colorless intermediates in the biosynthetic pathway of the pigmented flavonoids.
GO:00515590The chemical reactions and pathways resulting in the formation of phlobaphenes, red pigments with oligomeric or polymeric structure derived from the flavonoid intermediate flavan-4-ols.





Comparison with co-expressed genes



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