Biological process to genes

Query process ID GO:0009626
Process name The rapid, localized death of plant cells in response to invasion by a pathogen.
Organism Arabidopsis thaliana

Click Gene ID to show a list of co-expressed genes.

ECC Gene ID Repr. ID Gene name Functional description O.I. H.G. Other DB
XAt1g02860839559NLA (nitrogen limitation adaptation)Encodes a likely ubiquitin E3 ligase with RING and SPX domains that is involved in mediating immune responses.O.I.H.G.
XAt1g08450837365CRT3 (CALRETICULIN 3)Encodes calreticulin CRT3.O.I.H.G.
XAt1g12220837775RPS5 (RESISTANT TO P. SYRINGAE 5)Resistance gene, mediates resistance against the bacterial pathogen Pseudomonas syringae. Contains a putative nucleotide binding site composed of kinase-1a (or P-loop), kinase-2a, and putative kinase-3a domains, 13 imperfect leucine-rich repeats, a potential leucine zipper, and two uncharacterized motifs that are well conserved in products of previously isolated R genes. Confers resistance to Pseudomonas syringae strains that express avrPphB.O.I.H.G.
XAt1g19250838508FMO1 (FLAVIN-DEPENDENT MONOOXYGENASE 1)FMO1 is required for full expression of TIR-NB-LRR–conditioned resistance to avirulent pathogens and for basal resistance to invasive virulent pathogens. Functions in an EDS1-regulated but SA-independent mechanism that promotes resistance and cell death at pathogen infection sites.O.I.H.G.
XAt1g28380839735NSL1 (necrotic spotted lesions 1)This gene is predicted to encode a protein involved in negatively regulating salicylic acid-related defense responses and cell death programs. nsl1 mutants develop necrotic lesions spontaneously and show other features of a defense response, such as higher levels of SA and disease resistance-related transcripts, in the absence of a biotic stimulus. The NSL1 protein is predicted to have a MACPF domain, found in proteins that form a transmembrane pore in mammalian immune responses. NSL1 transcript levels do not appear to change in response to biotic stresses, but are elevated by cycloheximide in seedlings, and by sodium chloride in roots.O.I.H.G.
XAt1g71220843462EBS1 (EMS-mutagenized bri1 suppressor 1)F:transferase activity, transferring hexosyl groups, transferase activity, transferring glycosyl groups, UDP-glucose:glycoprotein glucosyltransferase activity;P:carbohydrate biosynthetic process, protein amino acid glycosylation;C:endoplasmic reticulum;MFOBPO.I.H.G.
XAt2g20310816550RIN13 (RPM1 INTERACTING PROTEIN 13)Encodes RPM1 Interacting Protein 13 (RIN13), a resistance protein interactor shown to positively enhance resistance function of RPM1.O.I.H.G.
XAt2g26560817197PLA2A (PHOSPHOLIPASE A 2A)encodes a lipid acyl hydrolase with wide substrate specificity that accumulates upon infection by fungal and bacterial pathogens. Protein is localized in the cytoplasm in healthy leaves, and in membranes in infected cells.O.I.H.G.
XAt3g07040819889RPM1 (RESISTANCE TO P. SYRINGAE PV MACULICOLA 1)Contains an N-terminal tripartite nucleotide binding site and a C-terminal tandem array of leucine-rich repeats. Confers resistance to Pseudomonas syringae strains that carry the avirulence genes avrB and avrRpm1.O.I.H.G.
XAt3g20600821607NDR1 (non race-specific disease resistance 1)Required for non-race specific resistance to bacterial and fungal pathogens.Mediates systemic acquired resistance (SAR) response.O.I.H.G.
XAt3g25070822098RIN4 (RPM1 INTERACTING PROTEIN 4)Encodes a member of the R protein complex and may represent a virulence target of type III pili effector proteins (virulence factors) from bacterial pathogens, which is 'guarded' by R protein complex (RPM1 and RPS2 proteins). RIN4 physically interacts with RPS2 and RPM1 in vivo. Bacterial avirulence (Avr) effectors AvrB, AvrRpm1, and AvrRpt2 induce a mobility shift in RIN4 and expression of AvrRpt2 induces rapid degradation of RIN4. RIN4 contains 2 sites for AvrRpt2 autocleavage, called RCS1 and RCS2. Overexpression of RIN4 inhibits multiple phenotypes associated with AvrRpt2 function and also inhibits PAMP-induced defense signaling. Attached to the plasma membrane at its carboxyl terminus. Cleaved by AvrRpt2 at two PxFGxW motifs, one releasing a large portion of RIN4 from the plasma membrane and both exposing amino-terminal residues that destabilized the carboxyl-terminal cleavage products by targeting them for N-end ubiquitylation and proteasomal degradation.O.I.H.G.
XAt3g28910822525MYB30 (MYB DOMAIN PROTEIN 30)transcription factor myb homologueO.I.H.G.
XAt3g46530823806RPP13 (RECOGNITION OF PERONOSPORA PARASITICA 13)Confers resistance to the biotrophic oomycete, Peronospora parasitica. Encodes an NBS-LRR type R protein with a putative amino-terminal leucine zipper. Fungal protein ATR13 induces RPP13 gene expression and disease resistance.O.I.H.G.
XAt3g48090823964EDS1 (enhanced disease susceptibility 1)Component of R gene-mediated disease resistance in Arabidopsis thaliana with homology to eukaryotic lipases.O.I.H.G.
XAt4g02640828219BZO2H1Encodes a basic leucine zipper (bZIP) transcription factor AtbZIP10. AtbZIP10 shuttles between the nucleus and the cytoplasm. It binds consensus G- and C-box DNA sequences. AtbZIP10 acts antagonistically with LSD1 in both pathogen-induced hypersensitive response and basal defense responses.O.I.H.G.
XAt4g12720826884NUDT7Encodes a protein with ADP-ribose hydrolase activity. Negatively regulates EDS1-conditioned plant defense and programmed cell death.O.I.H.G.
XAt4g20380827786zinc finger protein (LSD1)LSD1 monitors a superoxide-dependent signal and negatively regulates a plant cell death pathway. contains zinc-finger motifs. LSD1 negatively regulates a basal defense pathway that can act upstream or independently of both NIM1/NPR1 function and SA accumulation following avirulent or virulent pathogen challengeO.I.H.G.
XAt4g23210828420protein kinase family proteinEncodes a Cysteine-rich receptor-like kinase (CRK13). Overexpression of CRK13 leads to hypersensitive response cell death, and induces defense against pathogens by causing increased accumulation of salicylic acid.O.I.H.G.
XAt4g25230828626RIN2 (RPM1 INTERACTING PROTEIN 2)RPM1 interacting protein 2, has a CUE domain which is sufficient for the interaction with RPM1.Positive regulator of RPM1 and PRS2 mediated hypersensitive response.Functions as ubiquitin ligase and binds to RPM1.O.I.H.G.
XAt4g26090828715RPS2 (RESISTANT TO P. SYRINGAE 2)Encodes a plasma membrane protein with leucine-rich repeat, leucine zipper, and P loop domains that confers resistance to Pseudomonas syringae infection by interacting with the avirulence gene avrRpt2. RPS2 protein interacts directly with plasma membrane associated protein RIN4 and this interaction is disrupted by avrRpt2.O.I.H.G.
XAt4g37980829954ELI3-1 (ELICITOR-ACTIVATED GENE 3-1)F:oxidoreductase activity, binding, zinc ion binding, catalytic activity;P:response to bacterium, plant-type hypersensitive response;C:unknown;BOPFMAVO.I.H.G.
XAt4g37990829955ELI3-2 (ELICITOR-ACTIVATED GENE 3-2)Encodes an aromatic alcohol:NADP+ oxidoreductase whose mRNA levels are increased in response to treatment with a variety of phytopathogenic bacteria. Though similar to mannitol dehydrogenases, this enzyme does not have mannitol dehydrogenase activity.O.I.H.G.
XAt5g15410831393DND1 (DEFENSE NO DEATH 1)'defense, no death' gene (DND1) encodes a mutated cyclic nucleotide-gated cation channel; Same as CNGC2 (article ID 229): Cyclic nucleotide gated channel, activated by cAMP, conducts K+ and other monovalent cations but excludes Na+, does not contain the GYG amino acid sequence found in other channels with this conductivity profile. Conducts Ca2+ into cells which is linked to the generation of NO and the NO signaling pathway involved in the innate immune response to pathogens.O.I.H.G.
XAt5g20480832170EFR (EF-TU RECEPTOR)Encodes a predicted leucine-rich repeat receptor kinase (LRR-RLK). Functions as the receptor for bacterial PAMP (pathogen associated molecular patterns) EF-Tu.O.I.H.G.
XAt5g43470834367RPP8 (RECOGNITION OF PERONOSPORA PARASITICA 8)Confers resistance to Peronospora parasitica. In arabidopsis ecotype Dijon-17, HRT-mediated signaling is dependent on light for the induction of hypersensitive response and resistance to turnip crinkle virus.O.I.H.G.
XAt5g45050834536TTR1Encodes a member of WRKY Transcription Factor (Group II-e) that confers resistance to tobacco ringspot nepovirus.O.I.H.G.
XAt5g45250834561RPS4 (RESISTANT TO P. SYRINGAE 4)RPS4 belongs to the Toll/interleukin-1 receptor (TIR)-nucleotide binding site (NBS)-Leu-rich repeat (LRR) class of disease resistance (R ) genes. Confers specific resistance to Pseudomonas syringae pv. tomato carrying the avirulence gene AvrRPS4. Produces alternative transcripts with truncated open reading frames.O.I.H.G.
XAt5g51450835219RIN3 (RPM1 INTERACTING PROTEIN 3)Encodes RING-finger type ubiquitin ligases.O.I.H.G.
XAt5g54250835513ATCNGC4 (CYCLIC NUCLEOTIDE-GATED CATION CHANNEL 4)member of Cyclic nucleotide gated channel family, downstream component of the signaling pathways leading to HR resistance. mutant plants exhibit gene-for-gene disease resistance against avirulent Pseudomonas syringae despite the near-complete absence of the hypersensitive response (HR). Salicylic acid accumulation in dnd2 mutants is completely PAD4-independent.O.I.H.G.
SAt3g54420824608ATEP3encodes an EP3 chitinase that is expressed during somatic embryogenesis in 'nursing' cells surrounding the embryos but not in embryos themselves. The gene is also expressed in mature pollen and growing pollen tubes until they enter the receptive synergid, but not in endosperm and integuments as in carrot. Post-embryonically, expression is found in hydathodes, stipules, root epidermis and emerging root hairs.O.I.H.G.
SAt4g37930829949SHM1 (SERINE TRANSHYDROXYMETHYLTRANSFERASE 1)Encodes a protein with mitochondrial serine hydroxymethyltransferase activity, which functions in the photorespiratory pathway, catalyzes the conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. Involved in controlling cell damage caused by abiotic stress, such as high light and salt and the hypersensitive defense response of plants.O.I.H.G.
SAt5g64930836617CPR5 (CONSTITUTIVE EXPRESSION OF PR GENES 5)Regulator of expression of pathogenesis-related (PR) genes. Participates in signal transduction pathways involved in plant defense (systemic acquired resistance -SAR).O.I.H.G.
NAt5g61900836311BON1 (BONZAI 1)Encodes a plasma-membrane localized, copine-like protein, which is a member of a newly identified class of calcium-dependent, phospholipid binding proteins that are present in a wide range of organisms. Mutants exhibit temperature-sensitive growth defects and increased hypersensitive response where permissive conditions are low temperature (22 degrees Celsius) and low humidity. Gene is expressed at 22 but not at 28 (restrictive condition) degrees. Lethality of double mutants with BON3 can be partially suppressed by SNC1. Double mutants show defects in development that are genetically separable from hypersensitive/cell death response.O.I.H.G.



The upper GO terms

Process ID Gene number Process name
GO:00335540A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
GO:00340501Cell death in a host resulting from activation of host endogenous cellular processes after direct or indirect interaction with a symbiont (defined as the smaller of two, or more, organisms engaged in symbiosis, a close interaction encompassing mutualism through parasitism). An example of direct interaction is contact with penetrating hyphae of a fungus; an example of indirect interaction is encountering symbiont-secreted molecules.
GO:0045087126Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.



The lower GO terms

Process ID Gene number Process name





Comparison with co-expressed genes



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