Biological process to genes

Query process ID GO:0006623
Process name The process of directing proteins towards the vacuole, usually using signals contained within the protein.
Organism Arabidopsis thaliana

Click Gene ID to show a list of co-expressed genes.

ECC Gene ID Repr. ID Gene name Functional description O.I. H.G. Other DB
XAt1g26670839208VTI1Bmember of VTI1 Gene Family. Normally localizes to the transgolgi network and plasma membrane. A dominant mutation (zip1) alters the subcellular localization of VTI12 and suppresses loss of function mutation (zag1) of VTI11. Interacts with members of the SYP family. Involved in protein trafficking to protein storage vacuoles.O.I.H.G.
XAt2g26890817230GRV2 (GRAVITROPISM DEFECTIVE 2)GRV2 has sequence similarity to the C. elegans protein RME-8 which is involved in endocytosis. grv2 mutants result in a reduction in gravitropic response in hypocotyls and shoots but do not affect root gravitropism. The mutants are defective in amyloplast sedimentation.O.I.H.G.
XAt3g47700823924MAG2 (maigo2)Involved in transportation of seed storage proteins from the ER to the vacuole. Mutant seed cell accumulates the precursors of 12S globulin and 2S albumin instead of the vacuolar-located mature proteins.O.I.H.G.
XAt3g47810823935MAG1 (MAIGO 1)Homolog of yeast retromer subunit VPS29. Part of a retromer-like protein complex involved in endosome to lysosome protein transport.O.I.H.G.
XAt3g52850824451VSR1 (VACUOLAR SORTING RECEPTOR HOMOLOG 1)Encodes the Vacuolar Sorting Receptor-1 (VSR-1)/Epidermal Growth Factor Receptor-like protein1(VSR-1/ATELP1). Binds vacuolar targeting signals. Involved in sorting seed storage proteins into vacuoles.O.I.H.G.
XAt3g54300824597ATVAMP727 (VESICLE-ASSOCIATED MEMBRANE PROTEIN 727)Encodes a member of Synaptobrevin -like protein family. VAMP727 is a R-SNARE and interacts with SYP22/VTI11/SYP51. It is required for trafficking of storage proteins to the protein storage vacuoles (PSV) and also for PSV organization and biogenesis. Loss of function mutations have no phenotype but double mutants with SYP22 are embryo lethal.O.I.H.G.
XAt4g35870829741-F:molecular_function unknown;P:protein targeting to vacuole;C:membrane;MPFOO.I.H.G.
XAt5g03840831683TFL1 (TERMINAL FLOWER 1)Controls inflorescence meristem identity. Involved in the floral initiation process. Ortholog of the Antirrhinum gene CENTRORADIALIS (CEN). Involved in protein trafficking to the protein storage vacuole.O.I.H.G.
XAt5g06140830501SNX1 (SORTING NEXIN 1)Homolog of yeast retromer subunit VPS5. Part of a retromer-like protein complex involved in endosome to lysosome protein transport. In roots it co-localizes with the PIN2 auxin efflux carrier. Involved in endocytic sorting of membrane proteins including PIN2, BOR1 and BRI1.O.I.H.G.
XAt5g11710831043epsin N-terminal homology (ENTH) domain-containing protein / clathrin assembly protein-relatedEPSIN1 plays an important role in the vacuolar trafficking of soluble proteins at the trans-Golgi network via its interaction with gamma-ADR, VTI11, VSR1, and clathrin. Associated with actin filaments and with the Golgi complex. Expressed in most tissues.O.I.H.G.
XAt5g16830831546SYP21 (SYNTAXIN OF PLANTS 21)member of SYP2 Gene Family. Over-expression of the gene in tobacco protoplasts leads to a disruption of vacuolar transport from the prevacuolar compartment (PVC) to the vacuole, but not from the Golgi apparatus to the plasma membrane.O.I.H.G.
XAt5g39510833947SGR4 (SHOOT GRAVITROPSIM 4)Encodes a member of SNARE gene family. Homologous with yeast VTI1 and is involved in vesicle transport. Mutant alleles such as sgr4/zig are defective in the shoots response to gravity resulting in a zigzag growth pattern of the stem. Involved in protein trafficking to lytic vacuoles. Can conditionally substitute VTI12 in protein storage vacuole trafficking when plants are devoid of VTI12.O.I.H.G.
SAt1g09070837428SRC2 (SOYBEAN GENE REGULATED BY COLD-2)SRC2 specifically binds the peptide PIEPPPHH, and moves from ER to a vacuole fraction where it gets internalized. Involved in Protein Storage Vacuole targeting.O.I.H.G.
SAt1g30900839974vacuolar sorting receptor, putativeF:calcium ion binding;P:protein targeting to vacuole;C:integral to plasma membrane, Golgi transport complex;MOPBFAO.I.H.G.
SAt2g14720815960VSR-2encodes a vacuolar sorting receptorO.I.H.G.
SAt2g14740815962ATVSR3 (ARABIDOPSIS THALIANA VACULOLAR SORTING RECEPTOR 3)F:calcium ion binding;P:intracellular protein transport, protein targeting to vacuole;C:integral to plasma membrane, Golgi transport complex, membrane;MOPBFAO.I.H.G.
SAt2g30290817579vacuolar sorting receptor, putativeF:calcium ion binding;P:protein targeting to vacuole;C:integral to plasma membrane, Golgi transport complex;MOPBAO.I.H.G.
SAt2g34940818059vacuolar sorting receptor, putativeF:calcium ion binding;P:protein targeting to vacuole;C:integral to plasma membrane, Golgi transport complex;MOPBFO.I.H.G.
SAt4g20110827757vacuolar sorting receptor, putativeF:calcium ion binding;P:intracellular protein transport, N-terminal protein myristoylation, protein targeting to vacuole;C:trans-Golgi network, integral to plasma membrane, Golgi transport complex, membrane;MOPBFAO.I.H.G.



The upper GO terms

Process ID Gene number Process name
GO:00066059The process of targeting specific proteins to particular membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif.
GO:00070344The directed movement of substances into, out of or within a vacuole.



The lower GO terms

Process ID Gene number Process name
GO:00066220The process of directing proteins towards the lysosome using signals contained within the protein.
GO:00322580A constitutive biosynthetic process that occurs under nutrient-rich conditions, in which two resident vacuolar hydrolases, aminopeptidase I and alpha-mannosidase, are sequestered into vesicles; these vesicles are transported to, and then fuse with, the vacuole. This pathway is mostly observed in yeast.
GO:00433280The process of directing proteins towards the vacuole using signals contained within the protein, occurring during protein catabolism via the MVB pathway; the destruction of a protein or peptide covalently tagged with a ubiquitin, via the multivesicular body (MVB) sorting pathway.





Comparison with co-expressed genes



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