Homology analysis

Gene ID At5g05690
Functional description Encodes a member of the CP90A family, a cytochrome P450 monooxygenase which converts 6-deoxocathasterone to 6-deoxoteasterone in the late C6 oxidation pathway and cathasterone to teasterone in the early C6 oxidation pathway of brassinolide biosynthesis. Expressed in cotyledons and leaves. Mutants display de-etiolation and derepression of light-induced genes in the dark, dwarfism, male sterility and activation of stress-regulated genes in the light. The expression of the gene using a CPD promoter:LUC fusion construct was shown to be under circadian and light control. Additionally, the circadian regulation was shown to be independent of BR levels as it remains unchanged in bri1 mutant lines. CPD appears to be involved in the autonomous pathway that regulates the transition to flowering, primarily through a BRI1-mediated signaling pathway that affects FLC expression levels, as uncovered by double mutant analyses.

Click gene/probe ID to show a list of genes that are homologous to the gene.

Paralogous genes

HFEvBSGene IDRepr. IDGene NameFunctional DescriptionO.I.C.G.S.X.Other DB
0.022e-448At4g36380829790ROT3 (ROTUNDIFOLIA 3)Encodes a cytochrome P-450 gene that is involved in leaf blade expansion by controlling polar cell expansion in the leaf length direction. Member of the CYP90C CYP450 family. ROT3 was shown to be involved in brassinosteroid biosynthesis, most likely in the conversion step of typhasterol (TY) to castasterone (CS). As 6-deoxo-CS was unable to restore the phenotype of rot3-1, it has been postulated that ROT3 might be specifically involved in the conversion of TY to CS in the C6-oxidation pathway of brassinolide. Recently, CYP90C1 was shown to catalyse the C-23 hydroxylation of several brassinosteroids (the enzyme has a broad specificity for 22-hydroxylated substrates).O.I.C.G.S.X.
0.027e-446At3g50660824229DWF4 (DWARF 4)Encodes a 22α hydroxylase whose reaction is a rate-limiting step in brassinosteroid biosynthetic pathway. The protein is a member of CYP90B gene family. CLM is an epi-allele with small, compressed rosette, reduced internode length, and reduced fertility, appears in selfed ddm mutant plants possibly due to loss of cytosine methylation. Transcripts accumulate in actively growing tissues, and GUS expression is negatively regulated by brassinosteroids. Localized in the endoplasmic reticulum. The in vitro expressed protein can perform the C-22 hydroxylation of a variety of C27-, C28- and C29-sterols. Cholesterol was the best substrate, followed by campesterol. Sitosterol was a poor substrate.O.I.C.G.S.X.
0.021e-242At1g78490844185CYP708A3member of CYP708AO.I.C.G.S.X.
0.022e-138At4g25830828688integral membrane family proteinF:molecular_function unknown;P:biological_process unknown;C:endomembrane system;PO.I.C.G.S.X.
0.022e-138At4g09930826582avirulence-responsive family protein / avirulence induced gene (AIG1) family proteinF:GTP binding;P:response to bacterium;C:cellular_component unknown;MOBPFVAO.I.C.G.S.X.
0.012e-138At3g18080821333BGLU44 (B-S GLUCOSIDASE 44)F:in 6 functions;P:carbohydrate metabolic process;C:cytosolic ribosome, cell wall, plant-type cell wall;BOPMFAO.I.C.G.S.X.

Orthologous genes

HFEvBSGene IDOrganismRepr. IDGene NameFunctional DescriptionEvAGI codeArabidopsis gene nameO.I.C.G.S.X.Other DB
0.182e-23111GmaAffx.74065.1.S1_atGlycine maxBQ295944--7e-27At5g05690CPD (CONSTITUTIVE PHOTOMORPHOGENIC DWARF)O.I.C.G.S.X.
0.029e-238Contig20267_atHordeum vulgareContig20267--4e+0At5g42070unknown proteinO.I.C.G.S.X.
0.102e-656Os12g0139300Oryza sativaAK060257.1-E-class P450, group I family protein1e-6At5g05690CPD (CONSTITUTIVE PHOTOMORPHOGENIC DWARF)O.I.C.G.S.X.
0.315e-1583PtpAffx.79902.1.S1_atPopulus trichocarpaCV241105cytochrome P450 probable 6-deoxocathasterone to 6-deoxoteasterone or cathasterone to teasterone-2e-15At5g05690CPD (CONSTITUTIVE PHOTOMORPHOGENIC DWARF)O.I.C.G.S.X.
0.095e-859Ta.4986.1.S1_atTriticum aestivumCK160160--5e-8At5g05690CPD (CONSTITUTIVE PHOTOMORPHOGENIC DWARF)O.I.C.G.S.X.
0.103e-6521609099_atVitis viniferaCD005725hypothetical protein LOC100258692-9e-6At5g05690CPD (CONSTITUTIVE PHOTOMORPHOGENIC DWARF)O.I.C.G.S.X.
0.061e-344Zm.2464.1.S1_atZea maysAY108287.1hypothetical protein LOC100272666-3e-3At5g05690CPD (CONSTITUTIVE PHOTOMORPHOGENIC DWARF)O.I.C.G.S.X.

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