Homology analysis

Gene ID At5g04560
Gene name DME (DEMETER)
Functional description Encodes a DNA glycosylase DEMETER (DME). Responsible for endosperm maternal-allele-specific hypomethylation at the MEDEA (MEA) gene. DME can excise 5-methylcytosine in vitro and when expressed in E. coli. DME establishes MEA imprinting by removing 5-methylcytosine to activate the maternal allele.

Click gene/probe ID to show a list of genes that are homologous to the gene.

Paralogous genes

HFEvBSGene IDRepr. IDGene NameFunctional DescriptionO.I.C.G.S.X.Other DB
0.104e-36155At2g36490818224DML1 (DEMETER-LIKE 1)A repressor of transcriptional gene silencing. Functions by demethylating the target promoter DNA. Interacts physically with RPA2/ROR1. In the ros1 mutants, an increase in methylation is observed in a number of gene promoters. Among the loci affected by ros1, a few (RD29A and At1g76930) are affected in cytosine methylation in all sequence contexts (CpG, CpNpG or CpNpN), although many others are affected primarily in non-CpG contexts.O.I.C.G.S.X.
0.022e-759At4g34060829552DML3 (DEMETER-LIKE PROTEIN 3)Encodes a protein with 5-meC and thymine-DNA glycosylase activity with a preference for CpG and CpHpG sequences. Involved in maintaining methylation marks.O.I.C.G.S.X.
0.047e-448At3g10010820162DML2 (DEMETER-LIKE 2)Encodes a protein with DNA glycosylase activity that is involved in maintaining methylation marks.O.I.C.G.S.X.
0.014e-242At3g01175820400-F:molecular_function unknown;P:biological_process unknown;C:cellular_component unknown;POBMFO.I.C.G.S.X.
0.017e-138At2g31510817709IBR domain-containing protein / ARIADNE-like protein ARI7 (ARI7)F:protein binding, zinc ion binding, nucleic acid binding;P:unknown;C:unknown;MOFPVO.I.C.G.S.X.
0.017e-138At1g12220837775RPS5 (RESISTANT TO P. SYRINGAE 5)Resistance gene, mediates resistance against the bacterial pathogen Pseudomonas syringae. Contains a putative nucleotide binding site composed of kinase-1a (or P-loop), kinase-2a, and putative kinase-3a domains, 13 imperfect leucine-rich repeats, a potential leucine zipper, and two uncharacterized motifs that are well conserved in products of previously isolated R genes. Confers resistance to Pseudomonas syringae strains that express avrPphB.O.I.C.G.S.X.

Orthologous genes

HFEvBSGene IDOrganismRepr. IDGene NameFunctional DescriptionEvAGI codeArabidopsis gene nameO.I.C.G.S.X.Other DB
0.033e-1999GmaAffx.6691.1.A1_atGlycine maxAI442888--3e+0At5g41570WRKY24O.I.C.G.S.X.
0.124e-25117Contig10908_atHordeum vulgareContig10908--4e-25At5g04560DME (DEMETER)O.I.C.G.S.X.
0.144e-22109Os01g0217900Oryza sativaBI800881-Transcriptional activator DEMETER (DNAglycosylase-related protein DME). Splice isoform 21e-22At5g04560DME (DEMETER)O.I.C.G.S.X.
0.202e-44182PtpAffx.207576.1.S1_s_atPopulus trichocarpapmrna15038hypothetical protein-4e-45At5g04560DME (DEMETER)O.I.C.G.S.X.
0.054e-242Ta.7331.1.S1_atTriticum aestivumBQ169679--2e-23At2g36490DML1 (DEMETER-LIKE 1)O.I.C.G.S.X.
0.041e-5521619627_atVitis viniferaCB976213hypothetical protein LOC100257983-4e-6At5g04560DME (DEMETER)O.I.C.G.S.X.
0.071e-1585Zm.5328.1.S1_atZea maysCD441067hypothetical protein LOC100280151-4e-40At2g36490DML1 (DEMETER-LIKE 1)O.I.C.G.S.X.

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