Homology analysis

Gene ID At4g05160
Gene name 4-coumarate--CoA ligase, putative / 4-coumaroyl-CoA synthase, putative
Functional description Encodes a peroxisomal protein involved in the activation of fatty acids through esterification with CoA. At4g05160 preferentially activates fatty acids with medium chain length (C6:0 and C7:0) as well as even-numbered long-chain fatty acids (C14:0, C16:0 and C18:0). At4g05160 was also able to catalyze the conversion of OPC-6:0 to its CoA ester and is therefore thought to be involved in the peroxisomal β-oxidation steps of jasmonic acid biosynthesis.

Click gene/probe ID to show a list of genes that are homologous to the gene.

Paralogous genes

HFEvBSGene IDRepr. IDGene NameFunctional DescriptionO.I.C.G.S.X.Other DB
0.032e-1067At5g381208337924-coumarate--CoA ligase family protein / 4-coumaroyl-CoA synthase family proteinF:4-coumarate-CoA ligase activity;P:metabolic process;C:unknown;BOFMPAVO.I.C.G.S.X.
0.032e-1067At1g62940842596ACOS5 (ACYL-COA SYNTHETASE 5)encodes an acyl-CoA synthetase, has in vitro activity towards medium- to long-chain fatty acids and their hydroxylated derivatives. Expressed in the tapetum. Involved in pollen wall exine formation. Null mutants were devoid of pollen grains at anther maturity and were completely male sterile.O.I.C.G.S.X.
0.041e-552At1g516808415934CL1 (4-COUMARATE:COA LIGASE 1)encodes an isoform of 4-coumarate:CoA ligase (4CL), which is involved in the last step of the general phenylpropanoid pathway. In addition to 4-coumarate, it also converts ferulate. The catalytic efficiency was in the following (descending) order: p-coumaric acid, ferulic acid, caffeic acid and 5-OH-ferulic acid. At4CL1 was unable to use sinapic acid as substrate.O.I.C.G.S.X.
0.032e-448At1g650608428144CL3encodes an isoform of 4-coumarate:CoA ligase (4CL), which is involved in the last step of the general phenylpropanoid pathway. mRNA levels are not induced in response to wounding or to fungal infection by P. parasitica. mRNA is expressed in flowers, to a lesser degree in mature leaves and siliques and marginally in seedling roots and bolting stems of mature plants. The catalytic efficiency was in the following (descending) order: p-coumaric acid, caffeic acid, ferulic acid, cinnamic acid and 5-OH-ferulic acid. At4CL3 was unable to use sinapic acid as substrate.O.I.C.G.S.X.
0.018e-446At1g204808386364-coumarate--CoA ligase family protein / 4-coumaroyl-CoA synthase family proteinF:4-coumarate-CoA ligase activity;P:phenylpropanoid metabolic process, metabolic process;C:cellular_component unknown;BOFMPAVO.I.C.G.S.X.
0.033e-344At3g212308216774CL5 (4-coumarate:CoA ligase 5)The gene encodes a 4-coumarate coenzyme A ligase being able to use sinapate as substrate. The catalytic efficiency was in the following (descending) order: p-coumaric acid, caffeic acid, 5-OH-ferulic acid, ferulic acid and sinapic acid. At4CL5 was unable to use cinnamic acid as substrate. Knockout of At4CL5 (4cl5) revealed no effect on syringyl lignin content indicating that the activity observed does probably not occur in vivo.O.I.C.G.S.X.
0.043e-344At3g212408216784CL2 (4-COUMARATE:COA LIGASE 2)encodes an isoform of 4-coumarate:CoA ligase (4CL), which is involved in the last step of the general phenylpropanoid pathway. The catalytic efficiency was in the following (descending) order: p-coumaric acid, caffeic acid, ferulic acid, 5-OH-ferulic acid and cinnamic acid. At4CL2 was unable to use sinapic acid as substrate.O.I.C.G.S.X.

Orthologous genes

HFEvBSGene IDOrganismRepr. IDGene NameFunctional DescriptionEvAGI codeArabidopsis gene nameO.I.C.G.S.X.Other DB
0.217e-30133Gma.5032.1.S1_atGlycine maxBI970519--5e-31At4g051604-coumarate--CoA ligase, putative / 4-coumaroyl-CoA synthase, putativeO.I.C.G.S.X.
0.111e-1377Contig9988_atHordeum vulgareContig9988--2e-13At4g051604-coumarate--CoA ligase, putative / 4-coumaroyl-CoA synthase, putativeO.I.C.G.S.X.
0.113e-1171Os03g0152400Oryza sativaCR279600-4-coumarate--CoA ligase 1 (EC 6.2.1.12) (4CL 1)(4-coumaroyl-CoA synthase 1) (Clone 4CL14) (Fragment)6e-12At4g051604-coumarate--CoA ligase, putative / 4-coumaroyl-CoA synthase, putativeO.I.C.G.S.X.
0.235e-963Ptp.7231.1.A1_atPopulus trichocarpaCV2757034-coumarate-coa ligase-1e-11At4g051604-coumarate--CoA ligase, putative / 4-coumaroyl-CoA synthase, putativeO.I.C.G.S.X.
0.116e-859TaAffx.106960.2.S1_atTriticum aestivumCA708442--2e-8At4g051604-coumarate--CoA ligase, putative / 4-coumaroyl-CoA synthase, putativeO.I.C.G.S.X.
0.113e-19951606753_atVitis viniferaCF403699hypothetical protein LOC100267198-2e-23At4g051604-coumarate--CoA ligase, putative / 4-coumaroyl-CoA synthase, putativeO.I.C.G.S.X.
0.024e-136Zm.4493.1.A1_atZea maysCF015022hypothetical protein LOC100279480-4e-1At2g29780kelch repeat-containing F-box family proteinO.I.C.G.S.X.



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