Homology analysis

Gene ID At3g50660
Gene name DWF4 (DWARF 4)
Functional description Encodes a 22α hydroxylase whose reaction is a rate-limiting step in brassinosteroid biosynthetic pathway. The protein is a member of CYP90B gene family. CLM is an epi-allele with small, compressed rosette, reduced internode length, and reduced fertility, appears in selfed ddm mutant plants possibly due to loss of cytosine methylation. Transcripts accumulate in actively growing tissues, and GUS expression is negatively regulated by brassinosteroids. Localized in the endoplasmic reticulum. The in vitro expressed protein can perform the C-22 hydroxylation of a variety of C27-, C28- and C29-sterols. Cholesterol was the best substrate, followed by campesterol. Sitosterol was a poor substrate.

Click gene/probe ID to show a list of genes that are homologous to the gene.

Paralogous genes

HFEvBSGene IDRepr. IDGene NameFunctional DescriptionO.I.C.G.S.X.Other DB
0.028e-446At5g05690830453CPD (CONSTITUTIVE PHOTOMORPHOGENIC DWARF)Encodes a member of the CP90A family, a cytochrome P450 monooxygenase which converts 6-deoxocathasterone to 6-deoxoteasterone in the late C6 oxidation pathway and cathasterone to teasterone in the early C6 oxidation pathway of brassinolide biosynthesis. Expressed in cotyledons and leaves. Mutants display de-etiolation and derepression of light-induced genes in the dark, dwarfism, male sterility and activation of stress-regulated genes in the light. The expression of the gene using a CPD promoter:LUC fusion construct was shown to be under circadian and light control. Additionally, the circadian regulation was shown to be independent of BR levels as it remains unchanged in bri1 mutant lines. CPD appears to be involved in the autonomous pathway that regulates the transition to flowering, primarily through a BRI1-mediated signaling pathway that affects FLC expression levels, as uncovered by double mutant analyses.O.I.C.G.S.X.
0.015e-240At4g29210829042GGT4 (GAMMA-GLUTAMYL TRANSPEPTIDASE 4)The gene encodes a gamma-glutamyltransferase (AKA gamma-glutamyl transpeptidase, EC 2.3.2.2) that is located in the vacuole and is most active in roots. The encoded enzyme is involved in the initial degradation of glutathione conjugates in this cell compartment. It is also induced by xenobiotics and contributes to xenobiotics metabolism.O.I.C.G.S.X.
0.025e-240At1g144556240862unknown proteinF:molecular_function unknown;P:biological_process unknown;C:endomembrane system;POFMO.I.C.G.S.X.
0.015e-240At1g53380841774unknown proteinF:molecular_function unknown;P:biological_process unknown;C:cellular_component unknown;PBOO.I.C.G.S.X.

Orthologous genes

HFEvBSGene IDOrganismRepr. IDGene NameFunctional DescriptionEvAGI codeArabidopsis gene nameO.I.C.G.S.X.Other DB
0.143e-757GmaAffx.72637.1.S1_atGlycine maxBG316131--9e-8At3g50660DWF4 (DWARF 4)O.I.C.G.S.X.
0.024e-136Contig12510_atHordeum vulgareContig12510--4e-1At5g26790unknown proteinO.I.C.G.S.X.
0.024e-138Os12g0139300Oryza sativaAK060257.1-E-class P450, group I family protein1e-6At5g05690CPD (CONSTITUTIVE PHOTOMORPHOGENIC DWARF)O.I.C.G.S.X.
0.304e-22107Ptp.7196.1.S1_atPopulus trichocarpaCV280598cytochrome P450 probable campestanol to 6-deoxocathasterone or 6-oxocampestanol to cathasterone /// hypothetical protein-3e-22At3g50660DWF4 (DWARF 4)O.I.C.G.S.X.
0.043e-963Ta.27570.1.S1_atTriticum aestivumCD899311--3e-9At3g50660DWF4 (DWARF 4)O.I.C.G.S.X.
0.034e-3421619034_atVitis viniferaCK136955.1hypothetical protein LOC100264301-1e-3At4g15393CYP702A5O.I.C.G.S.X.
0.031e+034Zm.9503.1.A1_atZea maysBM269403hypothetical protein LOC100191795-2e-3At1g63700YDA (YODA)O.I.C.G.S.X.



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