Homology analysis

Gene ID At1g72970
Gene name HTH (HOTHEAD)
Functional description Originally identified as a mutation that causes floral organs to fuse together. About 10-20% of mutants also have defects in ovules. Mutants have reduced fertility most likely as because of fusions that pistil emergence. The protein has similarity to the mandelonitrile lyase family of FAD containing oxidoreductases and is predicted to be secreted (SignalP).It is expressed in all tissue layers of roots, inflorescences, stems, leaves, and flowers and is also expressed in siliques. Expression is highest in inflorescence and flower tissue.Transmission of mutant alleles to the progeny shows non mendelian segregation- a percentage of mutant alleles revert back to a previous parental (e.g. grandparental) wild type allele. It has been suggested that an RNA template driven or other extra-DNA genomic mechanism may be responsible for the non-mendelian inheritance of HTH. Reversion events in alleles at other loci have also been observed to occur in plants with an hth mutant background indicating a genome wide effect.

Click gene/probe ID to show a list of genes that are homologous to the gene.

Paralogous genes

HFEvBSGene IDRepr. IDGene NameFunctional DescriptionO.I.C.G.S.X.Other DB
0.034e-654At1g14190837979glucose-methanol-choline (GMC) oxidoreductase family proteinF:aldehyde-lyase activity, oxidoreductase activity, acting on CH-OH group of donors, FAD binding;P:cellular alcohol metabolic process;C:cellular_component unknown;OBFMPVAO.I.C.G.S.X.
0.036e-550At5g51930835268glucose-methanol-choline (GMC) oxidoreductase family proteinF:aldehyde-lyase activity, oxidoreductase activity, acting on CH-OH group of donors, oxidoreductase activity, FAD binding;P:cellular alcohol metabolic process;C:endomembrane system;OBFMPVAO.I.C.G.S.X.
0.022e-448At1g14185837978glucose-methanol-choline (GMC) oxidoreductase family proteinF:aldehyde-lyase activity, oxidoreductase activity, acting on CH-OH group of donors, FAD binding;P:cellular alcohol metabolic process;C:endomembrane system;OBFMPVAO.I.C.G.S.X.
0.011e-242At1g73050843636(R)-mandelonitrile lyase, putative / (R)-oxynitrilase, putativeF:oxidoreductase activity, acting on CH-OH group of donors, FAD binding;P:cyanide biosynthetic process, defense response;C:endomembrane system;OBFMPVAO.I.C.G.S.X.
0.012e-138At5g17910831659unknown proteinF:molecular_function unknown;P:biological_process unknown;C:mitochondrion;MOBFPVAO.I.C.G.S.X.
0.022e-138At3g56060824772glucose-methanol-choline (GMC) oxidoreductase family proteinF:aldehyde-lyase activity, oxidoreductase activity, acting on CH-OH group of donors, FAD binding;P:cellular alcohol metabolic process;C:endomembrane system;OBFMPVAO.I.C.G.S.X.
0.012e-138At3g55605824726mitochondrial glycoprotein family protein / MAM33 family proteinF:molecular_function unknown;P:biological_process unknown;C:mitochondrial matrix;PFOMO.I.C.G.S.X.
0.002e-138At1g70320843368UPL2 (UBIQUITIN-PROTEIN LIGASE 2)encodes a ubiquitin-protein ligase-like protein containing a HECT domain. There are six other HECT-domain UPLs in Arabidopsis.O.I.C.G.S.X.
0.029e-136At5g63740836494zinc finger protein-relatedF:molecular_function unknown;P:biological_process unknown;C:cellular_component unknown;BOMFPVAO.I.C.G.S.X.

Orthologous genes

HFEvBSGene IDOrganismRepr. IDGene NameFunctional DescriptionEvAGI codeArabidopsis gene nameO.I.C.G.S.X.Other DB
0.092e-1171Gma.10072.1.S1_atGlycine maxCD399353--1e-11At1g72970HTH (HOTHEAD)O.I.C.G.S.X.
0.052e-344Contig2265_atHordeum vulgareContig2265--4e-3At1g72970HTH (HOTHEAD)O.I.C.G.S.X.
0.042e-1275Os08g0401500Oryza sativaAK068301.1-Mandelonitrile lyase-like protein1e-12At1g72970HTH (HOTHEAD)O.I.C.G.S.X.
0.152e-1171PtpAffx.221521.1.S1_atPopulus trichocarpapmrna38448hypothetical protein-2e-11At1g72970HTH (HOTHEAD)O.I.C.G.S.X.
0.039e-136Ta.3259.1.S1_x_atTriticum aestivumCF133886--9e-2At5g51950glucose-methanol-choline (GMC) oxidoreductase family proteinO.I.C.G.S.X.
0.021e+0341609664_atVitis viniferaCB974632--9e+0At5g64080protease inhibitor/seed storage/lipid transfer protein (LTP) family proteinO.I.C.G.S.X.
0.042e-654Zm.1657.1.A1_atZea maysBG842419hypothetical protein LOC100192014-7e-2At5g51950glucose-methanol-choline (GMC) oxidoreductase family proteinO.I.C.G.S.X.



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